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High Fat Diet Regulation of β-Cell Proliferation and β-Cell Mass.

Golson ML, Misfeldt AA, Kopsombut UG, Petersen CP, Gannon M.

Open Endocrinol J. 2010;4. doi: 10.2174/1874216501004010066.


Milk signalling in the pathogenesis of type 2 diabetes.

Melnik BC.

Med Hypotheses. 2011 Apr;76(4):553-9. doi: 10.1016/j.mehy.2010.12.017. Epub 2011 Jan 19.


The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass.

Zhang H, Ackermann AM, Gusarova GA, Lowe D, Feng X, Kopsombut UG, Costa RH, Gannon M.

Mol Endocrinol. 2006 Aug;20(8):1853-66. Epub 2006 Mar 23.


Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen.

Zhang H, Zhang J, Pope CF, Crawford LA, Vasavada RC, Jagasia SM, Gannon M.

Diabetes. 2010 Jan;59(1):143-52. doi: 10.2337/db09-0050. Epub 2009 Oct 15.


Beta-cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1.

Ackermann Misfeldt A, Costa RH, Gannon M.

Diabetes. 2008 Nov;57(11):3069-77. doi: 10.2337/db08-0878. Epub 2008 Aug 26.


Beta-cell function and mass in type 2 diabetes.

Larsen MO.

Dan Med Bull. 2009 Aug;56(3):153-64.


Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure.

Kluth O, Mirhashemi F, Scherneck S, Kaiser D, Kluge R, Neschen S, Joost HG, Schürmann A.

Diabetologia. 2011 Mar;54(3):605-16. doi: 10.1007/s00125-010-1973-8. Epub 2010 Nov 24.


Butyrate alleviates metabolic impairments and protects pancreatic β cell function in pregnant mice with obesity.

Li HP, Chen X, Li MQ.

Int J Clin Exp Pathol. 2013 Jul 15;6(8):1574-84. Print 2013.


Activated FoxM1 attenuates streptozotocin-mediated β-cell death.

Golson ML, Maulis MF, Dunn JC, Poffenberger G, Schug J, Kaestner KH, Gannon MA.

Mol Endocrinol. 2014 Sep;28(9):1435-47. doi: 10.1210/me.2014-1024. Epub 2014 Jul 29.


The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.

Zmuda EJ, Qi L, Zhu MX, Mirmira RG, Montminy MR, Hai T.

Mol Endocrinol. 2010 Jul;24(7):1423-33. doi: 10.1210/me.2009-0463. Epub 2010 Jun 2.


Leucine signaling in the pathogenesis of type 2 diabetes and obesity.

Melnik BC.

World J Diabetes. 2012 Mar 15;3(3):38-53. doi: 10.4239/wjd.v3.i3.38.


Role of pancreatic β-cell death and inflammation in diabetes.

Quan W, Jo EK, Lee MS.

Diabetes Obes Metab. 2013 Sep;15 Suppl 3:141-51. doi: 10.1111/dom.12153. Review.


Interleukin-6 regulates pancreatic alpha-cell mass expansion.

Ellingsgaard H, Ehses JA, Hammar EB, Van Lommel L, Quintens R, Martens G, Kerr-Conte J, Pattou F, Berney T, Pipeleers D, Halban PA, Schuit FC, Donath MY.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13163-8. doi: 10.1073/pnas.0801059105. Epub 2008 Aug 21.


Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia.

Matias I, Gonthier MP, Orlando P, Martiadis V, De Petrocellis L, Cervino C, Petrosino S, Hoareau L, Festy F, Pasquali R, Roche R, Maj M, Pagotto U, Monteleone P, Di Marzo V.

J Clin Endocrinol Metab. 2006 Aug;91(8):3171-80. Epub 2006 May 9.


β-cell compensation concomitant with adaptive ER stress and β-cell neogenesis in a diet-induced type 2 diabetes model.

Huang H, Yang K, Wang R, Han WH, Kuny S, Zelmanovitz PH, Sauvé Y, Chan CB.

Appl Physiol Nutr Metab. 2019 May 13. doi: 10.1139/apnm-2019-0144. [Epub ahead of print]


The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.

Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH 3rd, Wright CV, White MF, Arden KC, Accili D.

J Clin Invest. 2002 Dec;110(12):1839-47.


Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance.

Usui M, Yamaguchi S, Tanji Y, Tominaga R, Ishigaki Y, Fukumoto M, Katagiri H, Mori K, Oka Y, Ishihara H.

Metabolism. 2012 Aug;61(8):1118-28. doi: 10.1016/j.metabol.2012.01.004. Epub 2012 Mar 3.


Ectopic fat storage in the pancreas using 1H-MRS: importance of diabetic status and modulation with bariatric surgery-induced weight loss.

Gaborit B, Abdesselam I, Kober F, Jacquier A, Ronsin O, Emungania O, Lesavre N, Alessi MC, Martin JC, Bernard M, Dutour A.

Int J Obes (Lond). 2015 Mar;39(3):480-7. doi: 10.1038/ijo.2014.126. Epub 2014 Jul 21.


Wild-type offspring of heterozygous prolactin receptor-null female mice have maladaptive β-cell responses during pregnancy.

Huang C.

J Physiol. 2013 Mar 1;591(5):1325-38. doi: 10.1113/jphysiol.2012.244830. Epub 2012 Dec 17.

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