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Dietary stimulators of the PGC-1 superfamily and mitochondrial biosynthesis in skeletal muscle. A mini-review.

Vaughan RA, Mermier CM, Bisoffi M, Trujillo KA, Conn CA.

J Physiol Biochem. 2014 Mar;70(1):271-84. doi: 10.1007/s13105-013-0301-4. Review.


AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle.

Smith BK, Mukai K, Lally JS, Maher AC, Gurd BJ, Heigenhauser GJ, Spriet LL, Holloway GP.

J Physiol. 2013 Mar 15;591(6):1551-61. doi: 10.1113/jphysiol.2012.245944.


MicroRNA-149 inhibits PARP-2 and promotes mitochondrial biogenesis via SIRT-1/PGC-1α network in skeletal muscle.

Mohamed JS, Hajira A, Pardo PS, Boriek AM.

Diabetes. 2014 May;63(5):1546-59. doi: 10.2337/db13-1364.


Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction.

Finley LW, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MC.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2931-6. doi: 10.1073/pnas.1115813109.


The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis.

Gurd BJ, Yoshida Y, Lally J, Holloway GP, Bonen A.

J Physiol. 2009 Apr 15;587(Pt 8):1817-28. doi: 10.1113/jphysiol.2008.168096.


PGC-1alpha's relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1alpha and PGC-1beta protein.

Holloway GP, Perry CG, Thrush AB, Heigenhauser GJ, Dyck DJ, Bonen A, Spriet LL.

Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1060-9. doi: 10.1152/ajpendo.00726.2007.


Enhanced lipid-but not carbohydrate-supported mitochondrial respiration in skeletal muscle of PGC-1α overexpressing mice.

Hoeks J, Arany Z, Phielix E, Moonen-Kornips E, Hesselink MK, Schrauwen P.

J Cell Physiol. 2012 Mar;227(3):1026-33. doi: 10.1002/jcp.22812.


Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis.

Gurd BJ.

Appl Physiol Nutr Metab. 2011 Oct;36(5):589-97. doi: 10.1139/h11-070. Review.


Expression of nuclear-encoded genes involved in mitochondrial biogenesis and dynamics in experimentally denervated muscle.

Wagatsuma A, Kotake N, Mabuchi K, Yamada S.

J Physiol Biochem. 2011 Sep;67(3):359-70. doi: 10.1007/s13105-011-0083-5.


Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity.

Hernández-Alvarez MI, Thabit H, Burns N, Shah S, Brema I, Hatunic M, Finucane F, Liesa M, Chiellini C, Naon D, Zorzano A, Nolan JJ.

Diabetes Care. 2010 Mar;33(3):645-51. doi: 10.2337/dc09-1305.


Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.

Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19926-31. doi: 10.1073/pnas.0810339105.


The role of nNOS and PGC-1α in skeletal muscle cells.

Baldelli S, Lettieri Barbato D, Tatulli G, Aquilano K, Ciriolo MR.

J Cell Sci. 2014 Nov 15;127(Pt 22):4813-20. doi: 10.1242/jcs.154229. Review.


Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle.

Vainshtein A, Tryon LD, Pauly M, Hood DA.

Am J Physiol Cell Physiol. 2015 May 1;308(9):C710-9. doi: 10.1152/ajpcell.00380.2014.


Training-induced mitochondrial adaptation: role of peroxisome proliferator-activated receptor γ coactivator-1α, nuclear factor-κB and β-blockade.

Feng H, Kang C, Dickman JR, Koenig R, Awoyinka I, Zhang Y, Ji LL.

Exp Physiol. 2013 Mar;98(3):784-95. doi: 10.1113/expphysiol.2012.069286.


PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle.

Pagel-Langenickel I, Bao J, Joseph JJ, Schwartz DR, Mantell BS, Xu X, Raghavachari N, Sack MN.

J Biol Chem. 2008 Aug 15;283(33):22464-72. doi: 10.1074/jbc.M800842200.

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