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Connexin 26 null mice exhibit spiral ganglion degeneration that can be blocked by BDNF gene therapy.

Takada Y, Beyer LA, Swiderski DL, O'Neal AL, Prieskorn DM, Shivatzki S, Avraham KB, Raphael Y.

Hear Res. 2014 Mar;309:124-35. doi: 10.1016/j.heares.2013.11.009. Epub 2013 Dec 12.


The effect of deafness duration on neurotrophin gene therapy for spiral ganglion neuron protection.

Wise AK, Tu T, Atkinson PJ, Flynn BO, Sgro BE, Hume C, O'Leary SJ, Shepherd RK, Richardson RT.

Hear Res. 2011 Aug;278(1-2):69-76. doi: 10.1016/j.heares.2011.04.010. Epub 2011 May 1.


Cochlear implants and ex vivo BDNF gene therapy protect spiral ganglion neurons.

Rejali D, Lee VA, Abrashkin KA, Humayun N, Swiderski DL, Raphael Y.

Hear Res. 2007 Jun;228(1-2):180-7. Epub 2007 Mar 7.


Mice with conditional deletion of Cx26 exhibit no vestibular phenotype despite secondary loss of Cx30 in the vestibular end organs.

Lee MY, Takada T, Takada Y, Kappy MD, Beyer LA, Swiderski DL, Godin AL, Brewer S, King WM, Raphael Y.

Hear Res. 2015 Oct;328:102-12. doi: 10.1016/j.heares.2015.07.018. Epub 2015 Jul 29.


Virally expressed connexin26 restores gap junction function in the cochlea of conditional Gjb2 knockout mice.

Yu Q, Wang Y, Chang Q, Wang J, Gong S, Li H, Lin X.

Gene Ther. 2014 Jan;21(1):71-80. doi: 10.1038/gt.2013.59. Epub 2013 Nov 14.


Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists.

Yu Q, Chang Q, Liu X, Wang Y, Li H, Gong S, Ye K, Lin X.

J Neurosci. 2013 Aug 7;33(32):13042-52. doi: 10.1523/JNEUROSCI.0854-13.2013.


Auditory responses in cochlear implant users with and without GJB2 deafness.

Propst EJ, Papsin BC, Stockley TL, Harrison RV, Gordon KA.

Laryngoscope. 2006 Feb;116(2):317-27.


Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochlea.

Sun Y, Tang W, Chang Q, Wang Y, Kong W, Lin X.

J Comp Neurol. 2009 Oct 20;516(6):569-79. doi: 10.1002/cne.22117.


Adenovirus-mediated expression of brain-derived neurotrophic factor protects spiral ganglion neurons from ototoxic damage.

Nakaizumi T, Kawamoto K, Minoda R, Raphael Y.

Audiol Neurootol. 2004 May-Jun;9(3):135-43.


Cell degeneration is not a primary causer for Connexin26 (GJB2) deficiency associated hearing loss.

Liang C, Zhu Y, Zong L, Lu GJ, Zhao HB.

Neurosci Lett. 2012 Oct 18;528(1):36-41. doi: 10.1016/j.neulet.2012.08.085. Epub 2012 Sep 11.


Over-expression of BDNF by adenovirus with concurrent electrical stimulation improves cochlear implant thresholds and survival of auditory neurons.

Chikar JA, Colesa DJ, Swiderski DL, Di Polo A, Raphael Y, Pfingst BE.

Hear Res. 2008 Nov;245(1-2):24-34. doi: 10.1016/j.heares.2008.08.005. Epub 2008 Aug 19.


Neurotrophins and electrical stimulation for protection and repair of spiral ganglion neurons following sensorineural hearing loss.

Shepherd RK, Coco A, Epp SB.

Hear Res. 2008 Aug;242(1-2):100-9. doi: 10.1016/j.heares.2007.12.005. Epub 2007 Dec 28.


Ultrastructural pathological changes in the cochlear cells of connexin 26 conditional knockout mice.

Lin L, Wang YF, Wang SY, Liu SF, Yu Z, Xi L, Li HW.

Mol Med Rep. 2013 Oct;8(4):1029-36. doi: 10.3892/mmr.2013.1614. Epub 2013 Aug 5.


Effects of localized neurotrophin gene expression on spiral ganglion neuron resprouting in the deafened cochlea.

Wise AK, Hume CR, Flynn BO, Jeelall YS, Suhr CL, Sgro BE, O'Leary SJ, Shepherd RK, Richardson RT.

Mol Ther. 2010 Jun;18(6):1111-22. doi: 10.1038/mt.2010.28. Epub 2010 Mar 9.


Type I vs type II spiral ganglion neurons exhibit differential survival and neuritogenesis during cochlear development.

Barclay M, Ryan AF, Housley GD.

Neural Dev. 2011 Oct 11;6:33. doi: 10.1186/1749-8104-6-33.


Viral vector tropism for supporting cells in the developing murine cochlea.

Sheffield AM, Gubbels SP, Hildebrand MS, Newton SS, Chiorini JA, Di Pasquale G, Smith RJ.

Hear Res. 2011 Jul;277(1-2):28-36. doi: 10.1016/j.heares.2011.03.016. Epub 2011 Apr 22.


Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochlea.

Zilberstein Y, Liberman MC, Corfas G.

J Neurosci. 2012 Jan 11;32(2):405-10. doi: 10.1523/JNEUROSCI.4678-11.2012. Erratum in: J Neurosci. 2012 Apr 4;32(14):5016.


Timed conditional null of connexin26 in mice reveals temporary requirements of connexin26 in key cochlear developmental events before the onset of hearing.

Chang Q, Tang W, Kim Y, Lin X.

Neurobiol Dis. 2015 Jan;73:418-27. doi: 10.1016/j.nbd.2014.09.005. Epub 2014 Sep 22.


Deficiency of transcription factor Brn4 disrupts cochlear gap junction plaques in a model of DFN3 non-syndromic deafness.

Kidokoro Y, Karasawa K, Minowa O, Sugitani Y, Noda T, Ikeda K, Kamiya K.

PLoS One. 2014 Sep 26;9(9):e108216. doi: 10.1371/journal.pone.0108216. eCollection 2014.

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