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Items: 1 to 20 of 251

1.

Cucurbitacin B inhibits the translational expression of hypoxia-inducible factor-1α.

Ma J, Zi Jiang Y, Shi H, Mi C, Li J, Xing Nan J, Wu X, Joon Lee J, Jin X.

Eur J Pharmacol. 2014 Jan 15;723:46-54. doi: 10.1016/j.ejphar.2013.12.005. Epub 2013 Dec 12.

PMID:
24333213
2.

Celastrol inhibits the HIF-1α pathway by inhibition of mTOR/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells.

Ma J, Han LZ, Liang H, Mi C, Shi H, Lee JJ, Jin X.

Oncol Rep. 2014 Jul;32(1):235-42. doi: 10.3892/or.2014.3211. Epub 2014 May 23.

PMID:
24859482
3.

4′,6-dihydroxy-4-methoxyisoaurone inhibits the HIF-1α pathway through inhibition of Akt/mTOR/p70S6K/4E-BP1 phosphorylation.

Mi C, Ma J, Shi H, Li J, Wang F, Lee JJ, Jin X.

J Pharmacol Sci. 2014;125(2):193-201.

PMID:
25075425
4.

Perillyl alcohol efficiently scavenges activity of cellular ROS and inhibits the translational expression of hypoxia-inducible factor-1α via mTOR/4E-BP1 signaling pathways.

Ma J, Li J, Wang KS, Mi C, Piao LX, Xu GH, Li X, Lee JJ, Jin X.

Int Immunopharmacol. 2016 Oct;39:1-9. doi: 10.1016/j.intimp.2016.06.034. Epub 2016 Jul 6.

PMID:
27394002
5.

Dihydrotanshinone I inhibits the translational expression of hypoxia-inducible factor-1α.

Li J, Mi C, Ma J, Wang KS, Lee JJ, Jin X.

Chem Biol Interact. 2015 Oct 5;240:48-58. doi: 10.1016/j.cbi.2015.08.006. Epub 2015 Aug 14.

PMID:
26282490
6.
7.

Tanshinone IIA inhibits HIF-1α and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway.

Li G, Shan C, Liu L, Zhou T, Zhou J, Hu X, Chen Y, Cui H, Gao N.

PLoS One. 2015 Feb 6;10(2):e0117440. doi: 10.1371/journal.pone.0117440. eCollection 2015.

8.

Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1α/VEGF signaling pathway in human bladder cancer cells.

Chen MC, Lee CF, Huang WH, Chou TC.

Biochem Pharmacol. 2013 May 1;85(9):1278-87. doi: 10.1016/j.bcp.2013.02.009. Epub 2013 Feb 14.

PMID:
23416116
9.

A quassinoid 6alpha-tigloyloxychaparrinone inhibits hypoxia-inducible factor-1 pathway by inhibition of eukaryotic translation initiation factor 4E phosphorylation.

Jin X, Jin HR, Lee D, Lee JH, Kim SK, Lee JJ.

Eur J Pharmacol. 2008 Sep 11;592(1-3):41-7. doi: 10.1016/j.ejphar.2008.06.104. Epub 2008 Jul 4.

PMID:
18639543
10.

Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways.

Mi C, Ma J, Wang KS, Zuo HX, Wang Z, Li MY, Piao LX, Xu GH, Li X, Quan ZS, Jin X.

J Ethnopharmacol. 2017 May 5;203:27-38. doi: 10.1016/j.jep.2017.03.033. Epub 2017 Mar 21.

PMID:
28341244
11.
12.

Suppression of the proliferation of hypoxia-Induced retinal pigment epithelial cell by rapamycin through the /mTOR/HIF-1α/VEGF/ signaling.

Liu NN, Zhao N, Cai N.

IUBMB Life. 2015 Jun;67(6):446-52. doi: 10.1002/iub.1382. Epub 2015 May 19.

13.
14.

Q39, a quinoxaline 1,4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1α expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells.

Weng Q, Zhang J, Cao J, Xia Q, Wang D, Hu Y, Sheng R, Wu H, Zhu D, Zhu H, He Q, Yang B.

Invest New Drugs. 2011 Dec;29(6):1177-87. doi: 10.1007/s10637-010-9462-y. Epub 2010 Jun 5.

PMID:
20524035
15.

Kamebakaurin inhibits the expression of hypoxia-inducible factor-1α and its target genes to confer antitumor activity.

Wang KS, Ma J, Mi C, Li J, Lee JJ, Jin X.

Oncol Rep. 2016 Apr;35(4):2045-52. doi: 10.3892/or.2016.4576. Epub 2016 Jan 19.

PMID:
26781327
16.

Liquiritigenin inhibits serum-induced HIF-1α and VEGF expression via the AKT/mTOR-p70S6K signalling pathway in HeLa cells.

Xie SR, Wang Y, Liu CW, Luo K, Cai YQ.

Phytother Res. 2012 Aug;26(8):1133-41. doi: 10.1002/ptr.3696. Epub 2011 Dec 14.

PMID:
22170854
17.

1,2,3,4,6-Penta-O-galloly-beta-D-glucose suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1α and signaling in LNCaP prostate cancer cells.

Park KY, Lee HJ, Jeong SJ, Lee HJ, Kim HS, Kim SH, Lim S, Kim HC, Lü J, Kim SH.

Biol Pharm Bull. 2010;33(11):1835-40.

18.

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3.

Dodd KM, Yang J, Shen MH, Sampson JR, Tee AR.

Oncogene. 2015 Apr 23;34(17):2239-50. doi: 10.1038/onc.2014.164. Epub 2014 Jun 16.

19.

Suppression of hypoxia-inducible factor 1α (HIF-1α) by tirapazamine is dependent on eIF2α phosphorylation rather than the mTORC1/4E-BP1 pathway.

Zhang J, Cao J, Weng Q, Wu R, Yan Y, Jing H, Zhu H, He Q, Yang B.

PLoS One. 2010 Nov 9;5(11):e13910. doi: 10.1371/journal.pone.0013910.

20.

Ascofuranone suppresses EGF-induced HIF-1α protein synthesis by inhibition of the Akt/mTOR/p70S6K pathway in MDA-MB-231 breast cancer cells.

Jeong YJ, Cho HJ, Magae J, Lee IK, Park KG, Chang YC.

Toxicol Appl Pharmacol. 2013 Dec 15;273(3):542-50. doi: 10.1016/j.taap.2013.09.027. Epub 2013 Oct 3.

PMID:
24096035

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