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Items: 1 to 20 of 106

1.

TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.

Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak M, Zuklys S, Sharrow S, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander GA, Takahama Y, Hodes RJ.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21107-12. doi: 10.1073/pnas.1314859111. Epub 2013 Dec 9.

2.

Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells.

White AJ, Nakamura K, Jenkinson WE, Saini M, Sinclair C, Seddon B, Narendran P, Pfeffer K, Nitta T, Takahama Y, Caamano JH, Lane PJ, Jenkinson EJ, Anderson G.

J Immunol. 2010 Oct 15;185(8):4769-76. doi: 10.4049/jimmunol.1002151. Epub 2010 Sep 22.

3.

Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.

Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.

J Immunol. 2014 Jan 15;192(2):630-40. doi: 10.4049/jimmunol.1302550. Epub 2013 Dec 13.

5.

Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla.

Desanti GE, Cowan JE, Baik S, Parnell SM, White AJ, Penninger JM, Lane PJ, Jenkinson EJ, Jenkinson WE, Anderson G.

J Immunol. 2012 Dec 15;189(12):5519-26. doi: 10.4049/jimmunol.1201815. Epub 2012 Nov 14.

6.

Stat3 Signaling Promotes Survival And Maintenance Of Medullary Thymic Epithelial Cells.

Lomada D, Jain M, Bolner M, Reeh KA, Kang R, Reddy MC, DiGiovanni J, Richie ER.

PLoS Genet. 2016 Jan 20;12(1):e1005777. doi: 10.1371/journal.pgen.1005777. eCollection 2016 Jan.

7.

NF-κB-inducing kinase in thymic stroma establishes central tolerance by orchestrating cross-talk with not only thymocytes but also dendritic cells.

Mouri Y, Nishijima H, Kawano H, Hirota F, Sakaguchi N, Morimoto J, Matsumoto M.

J Immunol. 2014 Nov 1;193(9):4356-67. doi: 10.4049/jimmunol.1400389. Epub 2014 Sep 26.

8.

Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program.

Nishikawa Y, Nishijima H, Matsumoto M, Morimoto J, Hirota F, Takahashi S, Luche H, Fehling HJ, Mouri Y, Matsumoto M.

J Immunol. 2014 Mar 15;192(6):2585-92. doi: 10.4049/jimmunol.1302786. Epub 2014 Feb 10.

9.

Antigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medulla.

Irla M, Guerri L, Guenot J, Sergé A, Lantz O, Liston A, Imhof BA, Palmer E, Reith W.

PLoS One. 2012;7(12):e52591. doi: 10.1371/journal.pone.0052591. Epub 2012 Dec 27.

10.

An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.

White AJ, Jenkinson WE, Cowan JE, Parnell SM, Bacon A, Jones ND, Jenkinson EJ, Anderson G.

J Immunol. 2014 Mar 15;192(6):2659-66. doi: 10.4049/jimmunol.1303057. Epub 2014 Feb 7.

11.

Thymocyte selection regulates the homeostasis of IL-7-expressing thymic cortical epithelial cells in vivo.

Ribeiro AR, Rodrigues PM, Meireles C, Di Santo JP, Alves NL.

J Immunol. 2013 Aug 1;191(3):1200-9. doi: 10.4049/jimmunol.1203042. Epub 2013 Jun 21.

12.

Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input.

White AJ, Withers DR, Parnell SM, Scott HS, Finke D, Lane PJ, Jenkinson EJ, Anderson G.

Eur J Immunol. 2008 Apr;38(4):942-7. doi: 10.1002/eji.200738052.

13.

The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, Inoue J.

Immunity. 2008 Sep 19;29(3):423-37. doi: 10.1016/j.immuni.2008.06.015. Erratum in: Immunity. 2013 Oct 17;39(4):796.

14.

Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.

Mouri Y, Yano M, Shinzawa M, Shimo Y, Hirota F, Nishikawa Y, Nii T, Kiyonari H, Abe T, Uehara H, Izumi K, Tamada K, Chen L, Penninger JM, Inoue J, Akiyama T, Matsumoto M.

J Immunol. 2011 May 1;186(9):5047-57. doi: 10.4049/jimmunol.1003533. Epub 2011 Mar 25.

15.

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells.

Aschenbrenner K, D'Cruz LM, Vollmann EH, Hinterberger M, Emmerich J, Swee LK, Rolink A, Klein L.

Nat Immunol. 2007 Apr;8(4):351-8. Epub 2007 Feb 25.

PMID:
17322887
16.

Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.

Irla M, Hugues S, Gill J, Nitta T, Hikosaka Y, Williams IR, Hubert FX, Scott HS, Takahama Y, Holländer GA, Reith W.

Immunity. 2008 Sep 19;29(3):451-63. doi: 10.1016/j.immuni.2008.08.007.

17.

The deubiquitinating enzyme CYLD regulates the differentiation and maturation of thymic medullary epithelial cells.

Reissig S, Hövelmeyer N, Tang Y, Weih D, Nikolaev A, Riemann M, Weih F, Waisman A.

Immunol Cell Biol. 2015 Jul;93(6):558-66. doi: 10.1038/icb.2014.122. Epub 2015 Jan 20.

PMID:
25601276
18.

Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK(+) medullary epithelial progenitors.

Baik S, Sekai M, Hamazaki Y, Jenkinson WE, Anderson G.

Eur J Immunol. 2016 Apr;46(4):857-62. doi: 10.1002/eji.201546253. Epub 2016 Feb 24.

19.

Thymic microenvironments for T-cell repertoire formation.

Nitta T, Murata S, Ueno T, Tanaka K, Takahama Y.

Adv Immunol. 2008;99:59-94. doi: 10.1016/S0065-2776(08)00603-2. Review.

PMID:
19117532
20.

Lymphotoxin β receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells.

Lkhagvasuren E, Sakata M, Ohigashi I, Takahama Y.

J Immunol. 2013 May 15;190(10):5110-7. doi: 10.4049/jimmunol.1203203. Epub 2013 Apr 12.

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