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Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells.

Gilkes DM, Xiang L, Lee SJ, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E384-93. doi: 10.1073/pnas.1321510111. Epub 2013 Dec 9.


Hypoxia promotes tumor cell motility via RhoA and ROCK1 signaling pathways.

Leong HS, Chambers AF.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):887-8. doi: 10.1073/pnas.1322484111. Epub 2014 Jan 7. No abstract available.


Role of RhoA and its effectors ROCK and mDia1 in the modulation of deformation-induced FAK, ERK, p38, and MLC motogenic signals in human Caco-2 intestinal epithelial cells.

Chaturvedi LS, Marsh HM, Basson MD.

Am J Physiol Cell Physiol. 2011 Nov;301(5):C1224-38. doi: 10.1152/ajpcell.00518.2010. Epub 2011 Aug 17.


Breast cancer antiestrogen resistance 3 (BCAR3) promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells.

Wilson AL, Schrecengost RS, Guerrero MS, Thomas KS, Bouton AH.

PLoS One. 2013 Jun 6;8(6):e65678. doi: 10.1371/journal.pone.0065678. Print 2013.


Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells.

Eitaki M, Yamamori T, Meike S, Yasui H, Inanami O.

BMC Cancer. 2012 Oct 12;12:469. doi: 10.1186/1471-2407-12-469.


2-Methoxyestradiol blocks the RhoA/ROCK1 pathway in human aortic smooth muscle cells.

Rigassi L, Barchiesi Bozzolo F, Lucchinetti E, Zaugg M, Fingerle J, Rosselli M, Imthurn B, Jackson EK, Dubey RK.

Am J Physiol Endocrinol Metab. 2015 Dec 15;309(12):E995-1007. doi: 10.1152/ajpendo.00267.2015. Epub 2015 Oct 20.


Extra-nuclear signaling of progesterone receptor to breast cancer cell movement and invasion through the actin cytoskeleton.

Fu XD, Giretti MS, Baldacci C, Garibaldi S, Flamini M, Sanchez AM, Gadducci A, Genazzani AR, Simoncini T.

PLoS One. 2008 Jul 30;3(7):e2790. doi: 10.1371/journal.pone.0002790.


NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction.

Zhang C, Wang HJ, Bao QC, Wang L, Guo TK, Chen WL, Xu LL, Zhou HS, Bian JL, Yang YR, Sun HP, Xu XL, You QD.

Oncotarget. 2016 Nov 8;7(45):73593-73606. doi: 10.18632/oncotarget.12435.


Up-regulation of Rhoa/Rho kinase pathway by translationally controlled tumor protein in vascular smooth muscle cells.

Maeng J, Sheverdin V, Shin H, Ha I, Bae SS, Yang-Yen HF, Lee K.

Int J Mol Sci. 2014 Jun 10;15(6):10365-76. doi: 10.3390/ijms150610365.


Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.

Cardone RA, Bagorda A, Bellizzi A, Busco G, Guerra L, Paradiso A, Casavola V, Zaccolo M, Reshkin SJ.

Mol Biol Cell. 2005 Jul;16(7):3117-27. Epub 2005 Apr 20.


Vascular endothelial growth factor C promotes cervical cancer metastasis via up-regulation and activation of RhoA/ROCK-2/moesin cascade.

He M, Cheng Y, Li W, Liu Q, Liu J, Huang J, Fu X.

BMC Cancer. 2010 Apr 29;10:170. doi: 10.1186/1471-2407-10-170.


Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells.

Ohta T, Takahashi T, Shibuya T, Amita M, Henmi N, Takahashi K, Kurachi H.

Cancer Biol Ther. 2012 Jan 1;13(1):25-33. doi: 10.4161/cbt.13.1.18440.


ROCK1 feedback regulation of the upstream small GTPase RhoA.

Tang AT, Campbell WB, Nithipatikom K.

Cell Signal. 2012 Jul;24(7):1375-80. doi: 10.1016/j.cellsig.2012.03.005. Epub 2012 Mar 11.


Hypoxia upregulates von Hippel-Lindau tumor-suppressor protein through RhoA-dependent activity in renal cell carcinoma.

Turcotte S, Desrosiers RR, Beliveau R.

Am J Physiol Renal Physiol. 2004 Feb;286(2):F338-48. Epub 2003 Oct 28.


Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly.

Orr AW, Pallero MA, Xiong WC, Murphy-Ullrich JE.

J Biol Chem. 2004 Nov 19;279(47):48983-92. Epub 2004 Sep 13.


The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells.

Paradiso A, Cardone RA, Bellizzi A, Bagorda A, Guerra L, Tommasino M, Casavola V, Reshkin SJ.

Breast Cancer Res. 2004;6(6):R616-28. Epub 2004 Sep 13.


Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells.

Perry NA, Vitolo MI, Martin SS, Kontrogianni-Konstantopoulos A.

Oncotarget. 2014 Sep 30;5(18):8558-68.


Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.

Wang T, Gilkes DM, Takano N, Xiang L, Luo W, Bishop CJ, Chaturvedi P, Green JJ, Semenza GL.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3234-42. doi: 10.1073/pnas.1410041111. Epub 2014 Jun 17.


RhoA and Rho-kinase dependent and independent signals mediate TGF-beta-induced pulmonary endothelial cytoskeletal reorganization and permeability.

Clements RT, Minnear FL, Singer HA, Keller RS, Vincent PA.

Am J Physiol Lung Cell Mol Physiol. 2005 Feb;288(2):L294-306. Epub 2004 Oct 8.

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