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Items: 1 to 20 of 153

1.

Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.

Hast BE, Cloer EW, Goldfarb D, Li H, Siesser PF, Yan F, Walter V, Zheng N, Hayes DN, Major MB.

Cancer Res. 2014 Feb 1;74(3):808-17. doi: 10.1158/0008-5472.CAN-13-1655. Epub 2013 Dec 9.

2.

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.

Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13568-73. doi: 10.1073/pnas.0806268105. Epub 2008 Aug 29. Erratum in: Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10393.

3.

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.

Taguchi K, Motohashi H, Yamamoto M.

Genes Cells. 2011 Feb;16(2):123-40. doi: 10.1111/j.1365-2443.2010.01473.x. Review.

4.
5.

Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.

Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB.

Cancer Res. 2013 Apr 1;73(7):2199-210. doi: 10.1158/0008-5472.CAN-12-4400. Epub 2013 Feb 4.

7.

Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2.

Sun Z, Zhang S, Chan JY, Zhang DD.

Mol Cell Biol. 2007 Sep;27(18):6334-49. Epub 2007 Jul 16.

8.

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.

Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman JG, Baylin SB, Sidransky D, Gabrielson E, Brock MV, Biswal S.

PLoS Med. 2006 Oct;3(10):e420.

9.

USP15 negatively regulates Nrf2 through deubiquitination of Keap1.

Villeneuve NF, Tian W, Wu T, Sun Z, Lau A, Chapman E, Fang D, Zhang DD.

Mol Cell. 2013 Jul 11;51(1):68-79. doi: 10.1016/j.molcel.2013.04.022. Epub 2013 May 30.

10.

The Keap1-Nrf2 system as an in vivo sensor for electrophiles.

Uruno A, Motohashi H.

Nitric Oxide. 2011 Aug 1;25(2):153-60. doi: 10.1016/j.niox.2011.02.007. Epub 2011 Mar 6.

PMID:
21385624
11.

Structural and Dynamic Characterization of Mutated Keap1 for Varied Affinity toward Nrf2: A Molecular Dynamics Simulation Study.

Cheng IC, Chen YJ, Ku CW, Huang YW, Yang CN.

J Chem Inf Model. 2015 Oct 26;55(10):2178-86. doi: 10.1021/acs.jcim.5b00300. Epub 2015 Sep 25.

PMID:
26348991
12.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.

Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M.

Mol Cell Biol. 2004 Aug;24(16):7130-9.

13.

A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD.

Mol Cell Biol. 2010 Jul;30(13):3275-85. doi: 10.1128/MCB.00248-10. Epub 2010 Apr 26.

14.

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.

Hayes JD, McMahon M.

Trends Biochem Sci. 2009 Apr;34(4):176-88. doi: 10.1016/j.tibs.2008.12.008. Epub 2009 Mar 25. Review.

PMID:
19321346
15.

Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers.

Yamadori T, Ishii Y, Homma S, Morishima Y, Kurishima K, Itoh K, Yamamoto M, Minami Y, Noguchi M, Hizawa N.

Oncogene. 2012 Nov 8;31(45):4768-77. doi: 10.1038/onc.2011.628. Epub 2012 Jan 16.

PMID:
22249257
16.

Molecular effects of cancer-associated somatic mutations on the structural and target recognition properties of Keap1.

Khan H, Killoran RC, Brickenden A, Fan J, Yang D, Choy WY.

Biochem J. 2015 Apr 1;467(1):141-51. doi: 10.1042/BJ20140761.

PMID:
25582950
17.

A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity.

Nioi P, Nguyen T.

Biochem Biophys Res Commun. 2007 Nov 3;362(4):816-21. Epub 2007 Aug 27.

PMID:
17822677
18.

Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.

Villeneuve NF, Lau A, Zhang DD.

Antioxid Redox Signal. 2010 Dec 1;13(11):1699-712. doi: 10.1089/ars.2010.3211. Epub 2010 Aug 14. Review.

19.

[Prothyomosin alpha interaction with KEAP1 doesn't lead to prothymosin alpha ubiquination and degradation].

Mel'nikov SV, Evstaf'eva AG, Vartapetian AB.

Mol Biol (Mosk). 2007 Sep-Oct;41(5):868-75. Russian.

PMID:
18240569
20.

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M.

Mol Cell Biol. 2004 Dec;24(24):10941-53.

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