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A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes.

Horenstein AL, Chillemi A, Zaccarello G, Bruzzone S, Quarona V, Zito A, Serra S, Malavasi F.

Oncoimmunology. 2013 Sep 1;2(9):e26246. Epub 2013 Sep 26.


A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation.

Morandi F, Morandi B, Horenstein AL, Chillemi A, Quarona V, Zaccarello G, Carrega P, Ferlazzo G, Mingari MC, Moretta L, Pistoia V, Malavasi F.

Oncotarget. 2015 Sep 22;6(28):25602-18. doi: 10.18632/oncotarget.4693.


CD56brightCD16- NK Cells Produce Adenosine through a CD38-Mediated Pathway and Act as Regulatory Cells Inhibiting Autologous CD4+ T Cell Proliferation.

Morandi F, Horenstein AL, Chillemi A, Quarona V, Chiesa S, Imperatori A, Zanellato S, Mortara L, Gattorno M, Pistoia V, Malavasi F.

J Immunol. 2015 Aug 1;195(3):965-72. doi: 10.4049/jimmunol.1500591. Epub 2015 Jun 19.


Unraveling the contribution of ectoenzymes to myeloma life and survival in the bone marrow niche.

Quarona V, Ferri V, Chillemi A, Bolzoni M, Mancini C, Zaccarello G, Roato I, Morandi F, Marimpietri D, Faccani G, Martella E, Pistoia V, Giuliani N, Horenstein AL, Malavasi F.

Ann N Y Acad Sci. 2015 Jan;1335:10-22. doi: 10.1111/nyas.12485. Epub 2014 Jul 21. Review.


Adenosine Generated in the Bone Marrow Niche Through a CD38-Mediated Pathway Correlates with Progression of Human Myeloma.

Horenstein AL, Quarona V, Toscani D, Costa F, Chillemi A, Pistoia V, Giuliani N, Malavasi F.

Mol Med. 2016 Oct 13;22. doi: 10.2119/molmed.2016.00198. [Epub ahead of print]


Roles and Modalities of Ectonucleotidases in Remodeling the Multiple Myeloma Niche.

Chillemi A, Quarona V, Antonioli L, Ferrari D, Horenstein AL, Malavasi F.

Front Immunol. 2017 Mar 20;8:305. doi: 10.3389/fimmu.2017.00305. eCollection 2017.


Immunohistochemical and functional analysis of ectonucleoside triphosphate diphosphohydrolase 1 (CD39) and ecto-5'-nucleotidase (CD73) in pig aortic valves.

Kaniewska E, Sielicka A, Sarathchandra P, Pelikant-Małecka I, Olkowicz M, Słomińska EM, Chester AH, Yacoub MH, Smoleński RT.

Nucleosides Nucleotides Nucleic Acids. 2014;33(4-6):305-12. doi: 10.1080/15257770.2014.885985.


Unconventional, adenosine-producing suppressor T cells induced by dendritic cells exposed to BPZE1 pertussis vaccine.

Fedele G, Sanseverino I, D'Agostino K, Schiavoni I, Locht C, Horenstein AL, Malavasi F, Ausiello CM.

J Leukoc Biol. 2015 Oct;98(4):631-9. doi: 10.1189/jlb.3A0315-101R. Epub 2015 Jun 18.


Enzymes involved in metabolism of extracellular nucleotides and nucleosides: functional implications and measurement of activities.

Yegutkin GG.

Crit Rev Biochem Mol Biol. 2014 Nov-Dec;49(6):473-97. doi: 10.3109/10409238.2014.953627. Review.


Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas.

Xu S, Shao QQ, Sun JT, Yang N, Xie Q, Wang DH, Huang QB, Huang B, Wang XY, Li XG, Qu X.

Neuro Oncol. 2013 Sep;15(9):1160-72. doi: 10.1093/neuonc/not067. Epub 2013 Jun 4.


Coordinated regulation in human T cells of nucleotide-hydrolyzing ecto-enzymatic activities, including CD38 and PC-1. Possible role in the recycling of nicotinamide adenine dinucleotide metabolites.

Deterre P, Gelman L, Gary-Gouy H, Arrieumerlou C, Berthelier V, Tixier JM, Ktorza S, Goding J, Schmitt C, Bismuth G.

J Immunol. 1996 Aug 15;157(4):1381-8.


CD39 and control of cellular immune responses.

Dwyer KM, Deaglio S, Gao W, Friedman D, Strom TB, Robson SC.

Purinergic Signal. 2007 Mar;3(1-2):171-80. doi: 10.1007/s11302-006-9050-y. Epub 2007 Feb 6.


Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity.

Deaglio S, Robson SC.

Adv Pharmacol. 2011;61:301-32. doi: 10.1016/B978-0-12-385526-8.00010-2. Review.


Contribution of adenosine-producing ectoenzymes to the mechanisms underlying the mitigation of maternal-fetal conflicts.

Cecati M, Emanuelli M, Giannubilo SR, Quarona V, Senetta R, Malavasi F, Tranquilli AL, Saccucci F.

J Biol Regul Homeost Agents. 2013 Apr-Jun;27(2):519-29.


CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death.

Serra S, Horenstein AL, Vaisitti T, Brusa D, Rossi D, Laurenti L, D'Arena G, Coscia M, Tripodo C, Inghirami G, Robson SC, Gaidano G, Malavasi F, Deaglio S.

Blood. 2011 Dec 1;118(23):6141-52. doi: 10.1182/blood-2011-08-374728. Epub 2011 Oct 13.


Trichomonas vaginalis NTPDase and ecto-5'-nucleotidase hydrolyze guanine nucleotides and increase extracellular guanosine levels under serum restriction.

Menezes CB, Durgante J, de Oliveira RR, Dos Santos VH, Rodrigues LF, Garcia SC, Dos Santos O, Tasca T.

Mol Biochem Parasitol. 2016 May;207(1):10-8. doi: 10.1016/j.molbiopara.2016.04.003. Epub 2016 May 2.


Vascular CD39/ENTPD1 directly promotes tumor cell growth by scavenging extracellular adenosine triphosphate.

Feng L, Sun X, Csizmadia E, Han L, Bian S, Murakami T, Wang X, Robson SC, Wu Y.

Neoplasia. 2011 Mar;13(3):206-16.


Methotrexate up-regulates ecto-5'-nucleotidase/CD73 and reduces the frequency of T lymphocytes in the glioblastoma microenvironment.

Figueiró F, de Oliveira CP, Bergamin LS, Rockenbach L, Mendes FB, Jandrey EH, Moritz CE, Pettenuzzo LF, Sévigny J, Guterres SS, Pohlmann AR, Battastini AM.

Purinergic Signal. 2016 Jun;12(2):303-12. doi: 10.1007/s11302-016-9505-8. Epub 2016 Feb 24.


Resident cardiac immune cells and expression of the ectonucleotidase enzymes CD39 and CD73 after ischemic injury.

Bönner F, Borg N, Burghoff S, Schrader J.

PLoS One. 2012;7(4):e34730. doi: 10.1371/journal.pone.0034730. Epub 2012 Apr 13.


Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states.

Longhi MS, Robson SC, Bernstein SH, Serra S, Deaglio S.

J Mol Med (Berl). 2013 Feb;91(2):165-72. doi: 10.1007/s00109-012-0991-z. Epub 2013 Jan 6. Review.

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