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Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.

Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A.

Nat Immunol. 2014 Feb;15(2):186-94. doi: 10.1038/ni.2772. Epub 2013 Dec 8.


TCR signaling: the barrier within.

Dustin ML, Davis SJ.

Nat Immunol. 2014 Feb;15(2):136-7. doi: 10.1038/ni.2811. No abstract available.


Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45.

Tan YX, Zikherman J, Weiss A.

Cold Spring Harb Symp Quant Biol. 2013;78:131-139. doi: 10.1101/sqb.2013.78.020347. Epub 2013 Oct 7.


Small molecule inhibition of Csk alters affinity recognition by T cells.

Manz BN, Tan YX, Courtney AH, Rutaganira F, Palmer E, Shokat KM, Weiss A.

Elife. 2015 Aug 24;4. doi: 10.7554/eLife.08088.


Nocodazole inhibits signal transduction by the T cell antigen receptor.

Huby RD, Weiss A, Ley SC.

J Biol Chem. 1998 May 15;273(20):12024-31.


Revisiting the Timing of Action of the PAG Adaptor Using Quantitative Proteomics Analysis of Primary T Cells.

Reginald K, Chaoui K, Roncagalli R, Beau M, Goncalves Menoita M, Monsarrat B, Burlet-Schiltz O, Malissen M, Gonzalez de Peredo A, Malissen B.

J Immunol. 2015 Dec 1;195(11):5472-81. doi: 10.4049/jimmunol.1501300. Epub 2015 Oct 28.


Role of Src-family kinases in formation of the cortical actin cap at the dorsal cell surface.

Kuga T, Hoshino M, Nakayama Y, Kasahara K, Ikeda K, Obata Y, Takahashi A, Higashiyama Y, Fukumoto Y, Yamaguchi N.

Exp Cell Res. 2008 Jun 10;314(10):2040-54. doi: 10.1016/j.yexcr.2008.03.018. Epub 2008 Apr 7.


Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis.

Le Bras S, Foucault I, Foussat A, Brignone C, Acuto O, Deckert M.

J Biol Chem. 2004 Apr 9;279(15):15550-60. Epub 2004 Jan 16.


Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading.

Carrizosa E, Gomez TS, Labno CM, Klos Dehring DA, Liu X, Freedman BD, Billadeau DD, Burkhardt JK.

J Immunol. 2009 Dec 1;183(11):7352-61. doi: 10.4049/jimmunol.0900973. Epub 2009 Nov 16.


Regulation of T cell development by c-Cbl: essential role of Lck.

Chiang YJ, Hodes RJ.

Int Immunol. 2015 May;27(5):245-51. doi: 10.1093/intimm/dxu105. Epub 2014 Dec 4.


p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells.

Zhang J, Salojin KV, Gao JX, Cameron MJ, Bergerot I, Delovitch TL.

J Immunol. 1999 Apr 1;162(7):3819-29.


Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold.

Stephen TL, Wilson BS, Laufer TM.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7415-20. doi: 10.1073/pnas.1119272109. Epub 2012 Apr 23.


Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.

Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ.

J Cell Biol. 2002 Apr 15;157(2):265-75. Epub 2002 Apr 8.


The effects of membrane compartmentalization of csk on TCR signaling.

Otáhal P, Pata S, Angelisová P, Hořejší V, Brdička T.

Biochim Biophys Acta. 2011 Feb;1813(2):367-76. doi: 10.1016/j.bbamcr.2010.12.003. Epub 2010 Dec 15.


Regulation of sustained actin dynamics by the TCR and costimulation as a mechanism of receptor localization.

Tskvitaria-Fuller I, Rozelle AL, Yin HL, Wülfing C.

J Immunol. 2003 Sep 1;171(5):2287-95.

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