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Items: 1 to 20 of 114

1.

Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury.

Lana B, Schlick B, Martin S, Pratt WS, Page KM, Goncalves L, Rahman W, Dickenson AH, Bauer CS, Dolphin AC.

Pain. 2014 Mar;155(3):522-33. doi: 10.1016/j.pain.2013.12.001. Epub 2013 Dec 6.

2.

Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin.

Luo ZD, Calcutt NA, Higuera ES, Valder CR, Song YH, Svensson CI, Myers RR.

J Pharmacol Exp Ther. 2002 Dec;303(3):1199-205.

4.

Altered expression of the voltage-gated calcium channel subunit α₂δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain.

Nieto-Rostro M, Sandhu G, Bauer CS, Jiruska P, Jefferys JG, Dolphin AC.

Neuroscience. 2014 Dec 26;283:124-37. doi: 10.1016/j.neuroscience.2014.03.013. Epub 2014 Mar 15.

5.

α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage.

Patel R, Bauer CS, Nieto-Rostro M, Margas W, Ferron L, Chaggar K, Crews K, Ramirez JD, Bennett DL, Schwartz A, Dickenson AH, Dolphin AC.

J Neurosci. 2013 Oct 16;33(42):16412-26. doi: 10.1523/JNEUROSCI.1026-13.2013.

6.

Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states.

Boroujerdi A, Zeng J, Sharp K, Kim D, Steward O, Luo ZD.

Pain. 2011 Mar;152(3):649-55. doi: 10.1016/j.pain.2010.12.014. Epub 2011 Jan 15.

7.

The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin.

Bauer CS, Nieto-Rostro M, Rahman W, Tran-Van-Minh A, Ferron L, Douglas L, Kadurin I, Sri Ranjan Y, Fernandez-Alacid L, Millar NS, Dickenson AH, Lujan R, Dolphin AC.

J Neurosci. 2009 Apr 1;29(13):4076-88. doi: 10.1523/JNEUROSCI.0356-09.2009.

8.

Changes in expression of voltage-dependent ion channel subunits in dorsal root ganglia of rats with radicular injury and pain.

Abe M, Kurihara T, Han W, Shinomiya K, Tanabe T.

Spine (Phila Pa 1976). 2002 Jul 15;27(14):1517-24; discussion 1525.

PMID:
12131710
9.

Dorsal root ganglion neurons show increased expression of the calcium channel alpha2delta-1 subunit following partial sciatic nerve injury.

Newton RA, Bingham S, Case PC, Sanger GJ, Lawson SN.

Brain Res Mol Brain Res. 2001 Nov 1;95(1-2):1-8.

PMID:
11687271
10.

Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α2δ-1 subunits.

Cassidy JS, Ferron L, Kadurin I, Pratt WS, Dolphin AC.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8979-84. doi: 10.1073/pnas.1403731111. Epub 2014 Jun 2.

11.

Analysis of the long-term actions of gabapentin and pregabalin in dorsal root ganglia and substantia gelatinosa.

Biggs JE, Boakye PA, Ganesan N, Stemkowski PL, Lantero A, Ballanyi K, Smith PA.

J Neurophysiol. 2014 Nov 15;112(10):2398-412. doi: 10.1152/jn.00168.2014. Epub 2014 Aug 13.

12.
13.

The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function.

Davies A, Douglas L, Hendrich J, Wratten J, Tran Van Minh A, Foucault I, Koch D, Pratt WS, Saibil HR, Dolphin AC.

J Neurosci. 2006 Aug 23;26(34):8748-57.

14.

Protective effects of gabapentin on allodynia and alpha 2 delta 1-subunit of voltage-dependent calcium channel in spinal nerve-ligated rats.

Hahm TS, Ahn HJ, Bae CD, Kim HS, Lim SW, Cho HS, Lee SM, Sim WS, Kim JA, Gwak MS, Choi SJ.

J Korean Med Sci. 2009 Feb;24(1):146-51. doi: 10.3346/jkms.2009.24.1.146. Epub 2009 Feb 28.

15.

Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α(2)δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity.

Yang Y, Yang F, Yang F, Li CL, Wang Y, Li Z, Lu YF, Yu YQ, Fu H, He T, Sun W, Wang RR, Chen J.

Neurosci Bull. 2016 Feb;32(1):41-50. doi: 10.1007/s12264-015-0008-3. Epub 2016 Jan 19.

PMID:
26781878
16.

High-voltage-activated calcium current subtypes in mouse DRG neurons adapt in a subpopulation-specific manner after nerve injury.

Murali SS, Napier IA, Mohammadi SA, Alewood PF, Lewis RJ, Christie MJ.

J Neurophysiol. 2015 Mar 1;113(5):1511-9. doi: 10.1152/jn.00608.2014. Epub 2014 Dec 10.

17.

Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats.

Luo ZD, Chaplan SR, Higuera ES, Sorkin LS, Stauderman KA, Williams ME, Yaksh TL.

J Neurosci. 2001 Mar 15;21(6):1868-75.

18.

Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.

Yoshizumi M, Parker RA, Eisenach JC, Hayashida K.

Anesthesiology. 2012 Jun;116(6):1347-53. doi: 10.1097/ALN.0b013e318254e6fd.

19.

Gabapentin decreases membrane calcium currents in injured as well as in control mammalian primary afferent neurons.

Sarantopoulos C, McCallum B, Kwok WM, Hogan Q.

Reg Anesth Pain Med. 2002 Jan-Feb;27(1):47-57.

PMID:
11799505
20.

Alternative splicing of the Ca2+ channel beta4 subunit confers specificity for gabapentin inhibition of Cav2.1 trafficking.

Mich PM, Horne WA.

Mol Pharmacol. 2008 Sep;74(3):904-12. doi: 10.1124/mol.108.045153. Epub 2008 Jun 26.

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