Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 134

1.

Lack of metabolic activation and predominant formation of an excreted metabolite of nontoxic platynecine-type pyrrolizidine alkaloids.

Ruan J, Liao C, Ye Y, Lin G.

Chem Res Toxicol. 2014 Jan 21;27(1):7-16. doi: 10.1021/tx4004159. Epub 2013 Dec 13.

PMID:
24308637
2.

Metabolic activation of pyrrolizidine alkaloids: insights into the structural and enzymatic basis.

Ruan J, Yang M, Fu P, Ye Y, Lin G.

Chem Res Toxicol. 2014 Jun 16;27(6):1030-9. doi: 10.1021/tx500071q. Epub 2014 May 22.

PMID:
24836403
5.

9-Glutathionyl-6,7-dihydro-1-hydroxymethyl-5H-pyrrolizine Is the Major Pyrrolic Glutathione Conjugate of Retronecine-Type Pyrrolizidine Alkaloids in Liver Microsomes and in Rats.

Chen M, Li L, Zhong D, Shen S, Zheng J, Chen X.

Chem Res Toxicol. 2016 Feb 15;29(2):180-9. doi: 10.1021/acs.chemrestox.5b00427. Epub 2016 Jan 26.

PMID:
26761523
6.

Comparison of metabolism-mediated effects of pyrrolizidine alkaloids in a HepG2/C3A cell-S9 co-incubation system and quantification of their glutathione conjugates.

Tamta H, Pawar RS, Wamer WG, Grundel E, Krynitsky AJ, Rader JI.

Xenobiotica. 2012 Oct;42(10):1038-48. doi: 10.3109/00498254.2012.679978. Epub 2012 Apr 23.

PMID:
22519982
7.
8.

Species differences in the in vitro metabolic activation of the hepatotoxic pyrrolizidine alkaloid clivorine.

Lin G, Cui YY, Liu XQ, Wang ZT.

Chem Res Toxicol. 2002 Nov;15(11):1421-8.

PMID:
12437333
9.
10.

Acquisition, transformation and maintenance of plant pyrrolizidine alkaloids by the polyphagous arctiid Grammia geneura.

Hartmann T, Theuring C, Beuerle T, Bernays EA, Singer MS.

Insect Biochem Mol Biol. 2005 Oct;35(10):1083-99.

PMID:
16102415
11.

Assessment of pyrrolizidine alkaloid-induced toxicity in an in vitro screening model.

Li YH, Kan WL, Li N, Lin G.

J Ethnopharmacol. 2013 Nov 25;150(2):560-7. doi: 10.1016/j.jep.2013.09.010. Epub 2013 Sep 14.

PMID:
24045176
12.

Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine.

Xia Q, Yan J, Chou MW, Fu PP.

Toxicol Lett. 2008 May 5;178(2):77-82. doi: 10.1016/j.toxlet.2008.02.008. Epub 2008 Mar 4.

PMID:
18395999
13.

Tissue distribution, core biosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species.

Frölich C, Ober D, Hartmann T.

Phytochemistry. 2007 Apr;68(7):1026-37. Epub 2007 Feb 22.

PMID:
17320124
14.
15.

Pyrrolizidine alkaloids of the endemic Mexican genus Pittocaulon and assignment of stereoisomeric 1,2-saturated necine bases.

Marín Loaiza JC, Ernst L, Beuerle T, Theuring C, Céspedes CL, Hartmann T.

Phytochemistry. 2008 Jan;69(1):154-67. Epub 2007 Aug 23.

PMID:
17719067
16.

Gender differences in microsomal metabolic activation of hepatotoxic clivorine in rat.

Lin G, Cui YY, Liu XQ.

Chem Res Toxicol. 2003 Jun;16(6):768-74.

PMID:
12807360
17.

Species differences in the hepatic microsomal enzyme metabolism of the pyrrolizidine alkaloids.

Huan JY, Miranda CL, Buhler DR, Cheeke PR.

Toxicol Lett. 1998 Oct 15;99(2):127-37.

PMID:
9817084
18.

Deacetylclivorine: a gender-selective metabolite of clivorine formed in female Sprague-Dawley rat liver microsomes.

Lin G, Tang J, Liu XQ, Jiang Y, Zheng J.

Drug Metab Dispos. 2007 Apr;35(4):607-13. Epub 2007 Jan 19.

19.
20.

Diversity of pyrrolizidine alkaloids in native and invasive Senecio pterophorus (Asteraceae): implications for toxicity.

Castells E, Mulder PP, Pérez-Trujillo M.

Phytochemistry. 2014 Dec;108:137-46. doi: 10.1016/j.phytochem.2014.09.006. Epub 2014 Sep 27.

PMID:
25269662

Supplemental Content

Support Center