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Cell surface self-assembly of hybrid nanoconjugates via oligonucleotide hybridization induces apoptosis.

Chu TW, Yang J, Zhang R, Sima M, Kopeček J.

ACS Nano. 2014 Jan 28;8(1):719-30. doi: 10.1021/nn4053827. Epub 2013 Dec 10.


Drug-free macromolecular therapeutics: Impact of structure on induction of apoptosis in Raji B cells.

Zhang L, Fang Y, Yang J, Kopeček J.

J Control Release. 2016 Dec 24. pii: S0168-3659(16)31273-1. doi: 10.1016/j.jconrel.2016.12.025. [Epub ahead of print]


Anti-CD20 multivalent HPMA copolymer-Fab' conjugates for the direct induction of apoptosis.

Chu TW, Yang J, Kopeček J.

Biomaterials. 2012 Oct;33(29):7174-81. doi: 10.1016/j.biomaterials.2012.06.024. Epub 2012 Jul 12.


Multimodality imaging of coiled-coil mediated self-assembly in a "drug-free" therapeutic system.

Zhang R, Yang J, Chu TW, Hartley JM, Kopeček J.

Adv Healthc Mater. 2015 May;4(7):1054-65. doi: 10.1002/adhm.201400679. Epub 2015 Jan 21.


Biological activity of anti-CD20 multivalent HPMA copolymer-Fab' conjugates.

Johnson RN, Kopečková P, Kopeček J.

Biomacromolecules. 2012 Mar 12;13(3):727-35. doi: 10.1021/bm201656k. Epub 2012 Feb 21.


Inhibition of human B-cell lymphoma by an anti-CD20 antibody and its chimeric F(ab')2 fragment via induction of apoptosis.

Liu Y, Zheng M, Lai Z, Xiong D, Fan D, Xu Y, Peng H, Shao X, Xu Y, Yang M, Wang J, Liu H, Xie Y, Yang C, Zhu Z.

Cancer Lett. 2004 Mar 18;205(2):143-53.


Binding to CD20 by anti-B1 antibody or F(ab')(2) is sufficient for induction of apoptosis in B-cell lines.

Cardarelli PM, Quinn M, Buckman D, Fang Y, Colcher D, King DJ, Bebbington C, Yarranton G.

Cancer Immunol Immunother. 2002 Mar;51(1):15-24. Epub 2001 Dec 18.


A Two-Step Pretargeted Nanotherapy for CD20 Crosslinking May Achieve Superior Anti-Lymphoma Efficacy to Rituximab.

Chu TW, Zhang R, Yang J, Chao MP, Shami PJ, Kopeček J.

Theranostics. 2015 Apr 26;5(8):834-46. doi: 10.7150/thno.12040. eCollection 2015.


Efficient elimination of B-lineage lymphomas by anti-CD20-auristatin conjugates.

Law CL, Cerveny CG, Gordon KA, Klussman K, Mixan BJ, Chace DF, Meyer DL, Doronina SO, Siegall CB, Francisco JA, Senter PD, Wahl AF.

Clin Cancer Res. 2004 Dec 1;10(23):7842-51. Erratum in: Clin Cancer Res. 2005 May 15;11(10):3969.


Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells.

Shan D, Ledbetter JA, Press OW.

Cancer Immunol Immunother. 2000 Mar;48(12):673-83.


[Apoptosis of human B cell lymphoma Raji cells induced by monovalent anti-CD20 antibody].

Liu YX, Fan DM, Xiong DS, Xu YF, Shao XF, Xu YS, Peng H, Yang M, Qin L, Zhu ZP, Yang CZ.

Ai Zheng. 2003 Dec;22(12):1249-53. Chinese.


Differential in vitro and in vivo antitumor effects mediated by anti-CD40 and anti-CD20 monoclonal antibodies against human B-cell lymphomas.

Funakoshi S, Longo DL, Murphy WJ.

J Immunother Emphasis Tumor Immunol. 1996 Mar;19(2):93-101.


Drug-free macromolecular therapeutics induce apoptosis of patient chronic lymphocytic leukemia cells.

Chu TW, Kosak KM, Shami PJ, Kopeček J.

Drug Deliv Transl Res. 2014 Dec;4(5-6):389-94. doi: 10.1007/s13346-014-0209-8.


Construction and characterization of a bispecific anti-CD20 antibody with potent antitumor activity against B-cell lymphoma.

Li B, Zhang X, Shi S, Zhao L, Zhang D, Qian W, Zheng L, Gao J, Wang H, Guo Y.

Cancer Res. 2010 Aug 1;70(15):6293-302. doi: 10.1158/0008-5472.CAN-10-0009. Epub 2010 Jul 14.


Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases.

Chow KU, Sommerlad WD, Boehrer S, Schneider B, Seipelt G, Rummel MJ, Hoelzer D, Mitrou PS, Weidmann E.

Haematologica. 2002 Jan;87(1):33-43.


An anti-CD20-IL-2 immunocytokine is highly efficacious in a SCID mouse model of established human B lymphoma.

Gillies SD, Lan Y, Williams S, Carr F, Forman S, Raubitschek A, Lo KM.

Blood. 2005 May 15;105(10):3972-8. Epub 2005 Feb 3.


Synthesis and evaluation of multivalent branched HPMA copolymer-Fab' conjugates targeted to the B-cell antigen CD20.

Johnson RN, Kopecková P, Kopecek J.

Bioconjug Chem. 2009 Jan;20(1):129-37. doi: 10.1021/bc800351m.


Coiled-coil based drug-free macromolecular therapeutics: in vivo efficacy.

Wu K, Yang J, Liu J, Kopeček J.

J Control Release. 2012 Jan 10;157(1):126-31. doi: 10.1016/j.jconrel.2011.08.002. Epub 2011 Aug 6.


Super-Resolution Imaging and Quantitative Analysis of Membrane Protein/Lipid Raft Clustering Mediated by Cell-Surface Self-Assembly of Hybrid Nanoconjugates.

Hartley JM, Chu TW, Peterson EM, Zhang R, Yang J, Harris J, Kopeček J.

Chembiochem. 2015 Aug 17;16(12):1725-9. doi: 10.1002/cbic.201500278. Epub 2015 Jul 2.

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