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Items: 1 to 20 of 131

1.

Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation.

Kim KD, Srikanth S, Tan YV, Yee MK, Jew M, Damoiseaux R, Jung ME, Shimizu S, An DS, Ribalet B, Waschek JA, Gwack Y.

J Immunol. 2014 Jan 1;192(1):110-22. doi: 10.4049/jimmunol.1302586. Epub 2013 Dec 4.

2.

Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function.

Kaufmann U, Shaw PJ, Kozhaya L, Subramanian R, Gaida K, Unutmaz D, McBride HJ, Feske S.

J Immunol. 2016 Jan 15;196(2):573-85. doi: 10.4049/jimmunol.1501406. Epub 2015 Dec 16.

3.

Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells.

Somasundaram A, Shum AK, McBride HJ, Kessler JA, Feske S, Miller RJ, Prakriya M.

J Neurosci. 2014 Jul 2;34(27):9107-23. doi: 10.1523/JNEUROSCI.0263-14.2014.

4.

The action of selective CRAC channel blockers is affected by the Orai pore geometry.

Derler I, Schindl R, Fritsch R, Heftberger P, Riedl MC, Begg M, House D, Romanin C.

Cell Calcium. 2013 Feb;53(2):139-51. doi: 10.1016/j.ceca.2012.11.005. Epub 2012 Dec 5.

5.

Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel.

Zhang HZ, Xu XL, Chen HY, Ali S, Wang D, Yu JW, Xu T, Nan FJ.

Acta Pharmacol Sin. 2015 Sep;36(9):1137-44. doi: 10.1038/aps.2015.52. Epub 2015 Aug 10.

6.

A novel human truncated IL12rβ1-Fc fusion protein ameliorates experimental autoimmune encephalomyelitis via specific binding of p40 to inhibit Th1 and Th17 cell differentiation.

Guo W, Wang C, Wang X, Luo C, Yu D, Wang Y, Chen Y, Lei W, Gao X, Yao W.

Oncotarget. 2015 Oct 6;6(30):28539-55. doi: 10.18632/oncotarget.5164.

7.

Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes.

Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A.

Cell Calcium. 2007 Aug;42(2):145-56. Epub 2007 Jun 18. Review.

PMID:
17572487
8.

microRNA cluster 106a~363 is involved in T helper 17 cell differentiation.

Kästle M, Bartel S, Geillinger-Kästle K, Irmler M, Beckers J, Ryffel B, Eickelberg O, Krauss-Etschmann S.

Immunology. 2017 Nov;152(3):402-413. doi: 10.1111/imm.12775. Epub 2017 Jul 28.

PMID:
28617945
9.

The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells.

Wang Y, Godec J, Ben-Aissa K, Cui K, Zhao K, Pucsek AB, Lee YK, Weaver CT, Yagi R, Lazarevic V.

Immunity. 2014 Mar 20;40(3):355-66. doi: 10.1016/j.immuni.2014.01.002. Epub 2014 Feb 13.

10.

Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology.

van Hamburg JP, de Bruijn MJ, Ribeiro de Almeida C, van Zwam M, van Meurs M, de Haas E, Boon L, Samsom JN, Hendriks RW.

Eur J Immunol. 2008 Sep;38(9):2573-86. doi: 10.1002/eji.200737840.

11.

Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter.

Hermann-Kleiter N, Meisel M, Fresser F, Thuille N, Müller M, Roth L, Katopodis A, Baier G.

J Autoimmun. 2012 Dec;39(4):428-40. doi: 10.1016/j.jaut.2012.07.007. Epub 2012 Aug 24.

12.

Dehydrodiconiferyl alcohol (DHCA) modulates the differentiation of Th17 and Th1 cells and suppresses experimental autoimmune encephalomyelitis.

Lee J, Choi J, Lee W, Ko K, Kim S.

Mol Immunol. 2015 Dec;68(2 Pt B):434-44. doi: 10.1016/j.molimm.2015.09.028. Epub 2015 Oct 23.

PMID:
26477735
13.

Stromal interaction molecule 1 (STIM1) and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells (NFAT) signaling in human umbilical vein endothelial cells.

Zhou MH, Zheng H, Si H, Jin Y, Peng JM, He L, Zhou Y, Muñoz-Garay C, Zawieja DC, Kuo L, Peng X, Zhang SL.

J Biol Chem. 2014 Oct 17;289(42):29446-56. doi: 10.1074/jbc.M114.578492. Epub 2014 Sep 4.

14.

RORγt-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells.

Park TY, Park SD, Cho JY, Moon JS, Kim NY, Park K, Seong RH, Lee SW, Morio T, Bothwell AL, Lee SK.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18673-8. doi: 10.1073/pnas.1413687112. Epub 2014 Dec 19. Erratum in: Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2115.

15.

Store-Operated Ca2+ Release-Activated Ca2+ Channels Regulate PAR2-Activated Ca2+ Signaling and Cytokine Production in Airway Epithelial Cells.

Jairaman A, Yamashita M, Schleimer RP, Prakriya M.

J Immunol. 2015 Sep 1;195(5):2122-33. doi: 10.4049/jimmunol.1500396. Epub 2015 Aug 3.

16.

p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.

Sasaki CY, Chen G, Munk R, Eitan E, Martindale J, Longo DL, Ghosh P.

Eur J Immunol. 2016 Jan;46(1):212-22. doi: 10.1002/eji.201445422. Epub 2015 Nov 19.

17.

LXR-mediated inhibition of CD4+ T helper cells.

Solt LA, Kamenecka TM, Burris TP.

PLoS One. 2012;7(9):e46615. doi: 10.1371/journal.pone.0046615. Epub 2012 Sep 28.

18.

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.

Solt LA, Kumar N, Nuhant P, Wang Y, Lauer JL, Liu J, Istrate MA, Kamenecka TM, Roush WR, Vidović D, Schürer SC, Xu J, Wagoner G, Drew PD, Griffin PR, Burris TP.

Nature. 2011 Apr 28;472(7344):491-4. doi: 10.1038/nature10075. Epub 2011 Apr 17.

19.

NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis.

Reppert S, Zinser E, Holzinger C, Sandrock L, Koch S, Finotto S.

Eur J Immunol. 2015 May;45(5):1426-40. doi: 10.1002/eji.201445150. Epub 2015 Mar 30.

20.

Generation and characterization of fully human monoclonal antibodies against human Orai1 for autoimmune disease.

Lin FF, Elliott R, Colombero A, Gaida K, Kelley L, Moksa A, Ho SY, Bykova E, Wong M, Rathanaswami P, Hu S, Sullivan JK, Nguyen HQ, McBride HJ.

J Pharmacol Exp Ther. 2013 May;345(2):225-38. doi: 10.1124/jpet.112.202788. Epub 2013 Mar 8.

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