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Items: 1 to 20 of 99

1.

Synthesis and in vitro evaluation of tetrahydroisoquinolines with pendent aromatics as sigma-2 (σ2) selective ligands.

Ashford ME, Nguyen VH, Greguric I, Pham TQ, Keller PA, Katsifis A.

Org Biomol Chem. 2014 Feb 7;12(5):783-94. doi: 10.1039/c3ob42254b. Epub 2013 Dec 5.

PMID:
24306445
2.
3.

Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents.

Pati ML, Abate C, Contino M, Ferorelli S, Luisi R, Carroccia L, Niso M, Berardi F.

Eur J Med Chem. 2015 Jan 7;89:691-700. doi: 10.1016/j.ejmech.2014.11.001. Epub 2014 Nov 4.

PMID:
25462276
4.

Substituted benzylaminoalkylindoles with preference for the sigma2 binding site.

Mamolo MG, Zampieri D, Zanette C, Florio C, Collina S, Urbano M, Azzolina O, Vio L.

Eur J Med Chem. 2008 Oct;43(10):2073-81. Epub 2007 Sep 26.

PMID:
18069094
5.

Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands.

Huang Y, Luedtke RR, Freeman RA, Wu L, Mach RH.

J Med Chem. 2001 May 24;44(11):1815-26.

PMID:
11356115
6.

Effect of structural modification in the amine portion of substituted aminobutyl-benzamides as ligands for binding σ1 and σ2 receptors.

Fan KH, Lever JR, Lever SZ.

Bioorg Med Chem. 2011 Mar 15;19(6):1852-9. doi: 10.1016/j.bmc.2011.02.006. Epub 2011 Feb 12.

7.

Ether modifications to 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (SA4503): effects on binding affinity and selectivity for sigma receptors and monoamine transporters.

Xu R, Lord SA, Peterson RM, Fergason-Cantrell EA, Lever JR, Lever SZ.

Bioorg Med Chem. 2015 Jan 1;23(1):222-30. doi: 10.1016/j.bmc.2014.11.007. Epub 2014 Nov 11.

8.

N-[omega-(Tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine are highly potent and selective sigma1 or sigma2 ligands.

Berardi F, Santoro S, Perrone R, Tortorella V, Govoni S, Lucchi L.

J Med Chem. 1998 Oct 8;41(21):3940-7.

PMID:
9767631
9.

Synthesis of (+)- and (-)-cis-2-[(1-adamantylamino)-methyl]-1-phenylcyclopropane derivatives as high affinity probes for sigma1 and sigma2 binding sites.

Marrazzo A, Prezzavento O, Pappalardo MS, Bousquet E, Iadanza M, Pike VW, Ronsisvalle G.

Farmaco. 2002 Jan;57(1):45-53.

PMID:
11902645
10.

A selective sigma-2 receptor ligand antagonizes cocaine-induced hyperlocomotion in mice.

Lever JR, Miller DK, Green CL, Fergason-Cantrell EA, Watkinson LD, Carmack TL, Fan KH, Lever SZ.

Synapse. 2014 Feb;68(2):73-84. doi: 10.1002/syn.21717. Epub 2013 Oct 24.

PMID:
24123353
11.

Synthesis of bridged piperazines with sigma receptor affinity.

Weigl M, Wünsch B.

Eur J Med Chem. 2007 Oct;42(10):1247-62. Epub 2007 Feb 25.

PMID:
17420073
12.

Design, synthesis, and structure-affinity relationships of regioisomeric N-benzyl alkyl ether piperazine derivatives as sigma-1 receptor ligands.

Moussa IA, Banister SD, Beinat C, Giboureau N, Reynolds AJ, Kassiou M.

J Med Chem. 2010 Aug 26;53(16):6228-39. doi: 10.1021/jm100639f.

PMID:
20662542
13.

2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives: novel, potent and selective sigma1 receptor ligands.

Ucar H, Cacciaguerra S, Spampinato S, Van derpoorten K, Isa M, Kanyonyo M, Poupaert JH.

Eur J Pharmacol. 1997 Sep 24;335(2-3):267-73.

PMID:
9369382
14.

Improving selectivity preserving affinity: new piperidine-4-carboxamide derivatives as effective sigma-1-ligands.

Zampieri D, Laurini E, Vio L, Fermeglia M, Pricl S, Wünsch B, Schepmann D, Mamolo MG.

Eur J Med Chem. 2015 Jan 27;90:797-808. doi: 10.1016/j.ejmech.2014.12.018. Epub 2014 Dec 12.

PMID:
25528334
15.

1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 (sigma1) and sigma-2 (sigma2) receptor ligands: a review.

Berardi F, Abate C, Ferorelli S, Colabufo NA, Perrone R.

Cent Nerv Syst Agents Med Chem. 2009 Sep;9(3):205-19. Review.

PMID:
20021355
16.

Synthesis and receptor binding studies of some new arylcarboxamide derivatives as sigma-1 ligands.

Zampieri D, Laurini E, Vio L, Golob S, Fermeglia M, Pricl S, Mamolo MG.

Bioorg Med Chem Lett. 2014 Feb 15;24(4):1021-5. doi: 10.1016/j.bmcl.2014.01.032. Epub 2014 Jan 20.

PMID:
24486131
17.

Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles.

Perregaard J, Moltzen EK, Meier E, Sánchez C.

J Med Chem. 1995 May 26;38(11):1998-2008.

PMID:
7783131
18.
19.

Synthesis and pharmacological evaluation of 6-piperidino- and 6-piperazinoalkyl-2(3H)-benzothiazolones as mixed sigma/5-HT(1A) ligands.

Mouithys-Mickalad A, Poupaert JH, Spampinato S, Lesieur D.

Bioorg Med Chem Lett. 2002 Apr 22;12(8):1149-52.

PMID:
11934576

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