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Items: 1 to 20 of 89

1.

An HDAC in the cytoplasm, not the nucleus, plays a pathogenic role in Huntington's disease.

Robinson R.

PLoS Biol. 2013 Nov;11(11):e1001718. doi: 10.1371/journal.pbio.1001718. Epub 2013 Nov 26. No abstract available.

2.

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.

Mielcarek M, Landles C, Weiss A, Bradaia A, Seredenina T, Inuabasi L, Osborne GF, Wadel K, Touller C, Butler R, Robertson J, Franklin SA, Smith DL, Park L, Marks PA, Wanker EE, Olson EN, Luthi-Carter R, van der Putten H, Beaumont V, Bates GP.

PLoS Biol. 2013 Nov;11(11):e1001717. doi: 10.1371/journal.pbio.1001717. Epub 2013 Nov 26.

3.
4.

Huntington's disease. Exploiting expression.

Bates GP.

Nature. 2001 Oct 18;413(6857):691, 693-4. No abstract available.

PMID:
11607014
5.

Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein.

Hoshino M, Tagawa K, Okuda T, Murata M, Oyanagi K, Arai N, Mizutani T, Kanazawa I, Wanker EE, Okazawa H.

J Neurochem. 2003 Oct;87(1):257-67.

6.

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.

Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, Kurokawa R, Housman DE, Jackson GR, Marsh JL, Thompson LM.

Nature. 2001 Oct 18;413(6857):739-43.

PMID:
11607033
7.

Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease.

Bobrowska A, Paganetti P, Matthias P, Bates GP.

PLoS One. 2011;6(6):e20696. doi: 10.1371/journal.pone.0020696. Epub 2011 Jun 3.

8.

Huntingtin aggregation kinetics and their pathological role in a Drosophila Huntington's disease model.

Weiss KR, Kimura Y, Lee WC, Littleton JT.

Genetics. 2012 Feb;190(2):581-600. doi: 10.1534/genetics.111.133710. Epub 2011 Nov 17.

9.

Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.

Clemens LE, Weber JJ, Wlodkowski TT, Yu-Taeger L, Michaud M, Calaminus C, Eckert SH, Gaca J, Weiss A, Magg JC, Jansson EK, Eckert GP, Pichler BJ, Bordet T, Pruss RM, Riess O, Nguyen HP.

Brain. 2015 Dec;138(Pt 12):3632-53. doi: 10.1093/brain/awv290. Epub 2015 Oct 21.

PMID:
26490331
10.

Huntington's disease: flipping a switch on huntingtin.

Greiner ER, Yang XW.

Nat Chem Biol. 2011 Jun 17;7(7):412-4. doi: 10.1038/nchembio.604. No abstract available.

PMID:
21685885
11.

Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity.

Bates EA, Victor M, Jones AK, Shi Y, Hart AC.

J Neurosci. 2006 Mar 8;26(10):2830-8.

12.

Huntingtin-protein interactions and the pathogenesis of Huntington's disease.

Li SH, Li XJ.

Trends Genet. 2004 Mar;20(3):146-54. Review.

PMID:
15036808
13.

Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation.

De Rooij KE, Dorsman JC, Smoor MA, Den Dunnen JT, Van Ommen GJ.

Hum Mol Genet. 1996 Aug;5(8):1093-9.

PMID:
8842726
15.

Protein aggregation in Huntington's disease.

Hoffner G, Djian P.

Biochimie. 2002 Apr;84(4):273-8. Review.

PMID:
12106904
16.

New clues found to Huntington's.

Barinaga M.

Science. 1995 Nov 17;270(5239):1110. No abstract available.

PMID:
7502028
17.

Nucleocytoplasmic trafficking and transcription effects of huntingtin in Huntington's disease.

Truant R, Atwal RS, Burtnik A.

Prog Neurobiol. 2007 Nov;83(4):211-27. Epub 2007 Jan 22. Review.

PMID:
17240517
18.

Characterising the Huntington's disease gene product.

Wood J, MacMillan JC, Thomas P, Lowenstein PR, Harper PS, Jones AL.

Biochem Soc Trans. 1995 Nov;23(4):595S. No abstract available.

PMID:
8654780
19.

Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.

Valencia A, Reeves PB, Sapp E, Li X, Alexander J, Kegel KB, Chase K, Aronin N, DiFiglia M.

J Neurosci Res. 2010 Jan;88(1):179-90. doi: 10.1002/jnr.22184.

PMID:
19642201
20.

Huntington's disease.

Davies S, Ramsden DB.

Mol Pathol. 2001 Dec;54(6):409-13. Review.

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