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Knockdown of Sec8 promotes cell-cycle arrest at G1/S phase by inducing p21 via control of FOXO proteins.

Tanaka T, Iino M.

FEBS J. 2014 Feb;281(4):1068-84. doi: 10.1111/febs.12669. Epub 2014 Jan 9.


FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1).

Kloet DE, Polderman PE, Eijkelenboom A, Smits LM, van Triest MH, van den Berg MC, Groot Koerkamp MJ, van Leenen D, Lijnzaad P, Holstege FC, Burgering BM.

Biochem J. 2015 Jul 15;469(2):289-98. doi: 10.1042/BJ20140831. Epub 2015 May 20.


Stat6 cooperates with Sp1 in controlling breast cancer cell proliferation by modulating the expression of p21(Cip1/WAF1) and p27 (Kip1).

Wei M, Liu B, Gu Q, Su L, Yu Y, Zhu Z.

Cell Oncol (Dordr). 2013 Feb;36(1):79-93. doi: 10.1007/s13402-012-0115-3. Epub 2012 Nov 27.


LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression.

Liu W, Dai Q, Lu N, Wei L, Ha J, Rong J, Mu R, You Q, Li Z, Guo Q.

Biochem Cell Biol. 2011 Jun;89(3):287-98. doi: 10.1139/O10-162. Epub 2011 Apr 14.


p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint.

Lafarga V, Cuadrado A, Lopez de Silanes I, Bengoechea R, Fernandez-Capetillo O, Nebreda AR.

Mol Cell Biol. 2009 Aug;29(16):4341-51. doi: 10.1128/MCB.00210-09. Epub 2009 Jun 15.


TIGAR induces p53-mediated cell-cycle arrest by regulation of RB-E2F1 complex.

Madan E, Gogna R, Kuppusamy P, Bhatt M, Pati U, Mahdi AA.

Br J Cancer. 2012 Jul 24;107(3):516-26. doi: 10.1038/bjc.2012.260. Epub 2012 Jul 10.


Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradation.

Sarmento LM, Huang H, Limon A, Gordon W, Fernandes J, Tavares MJ, Miele L, Cardoso AA, Classon M, Carlesso N.

J Exp Med. 2005 Jul 4;202(1):157-68.


Acute renal failure during sepsis: potential role of cell cycle regulation.

Yang QH, Liu DW, Long Y, Liu HZ, Chai WZ, Wang XT.

J Infect. 2009 Jun;58(6):459-64. doi: 10.1016/j.jinf.2009.04.003. Epub 2009 Apr 17.


Dux4 induces cell cycle arrest at G1 phase through upregulation of p21 expression.

Xu H, Wang Z, Jin S, Hao H, Zheng L, Zhou B, Zhang W, Lv H, Yuan Y.

Biochem Biophys Res Commun. 2014 Mar 28;446(1):235-40. doi: 10.1016/j.bbrc.2014.02.105. Epub 2014 Feb 28. Erratum in: Biochem Biophys Res Commun. 2014 Jul 18;450(1):927.


TGF-β-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray irradiated HeLa cells dependent on p21 induction but independent of NF-κB, p38 MAPK and ERK phosphorylations.

Furusawa Y, Wei ZL, Sakurai H, Tabuchi Y, Li P, Zhao QL, Nomura T, Saiki I, Kondo T.

Radiat Res. 2012 Jun;177(6):766-74. Epub 2012 Apr 10.


CCAAT/enhancer binding protein alpha interacts with ZTA and mediates ZTA-induced p21(CIP-1) accumulation and G(1) cell cycle arrest during the Epstein-Barr virus lytic cycle.

Wu FY, Chen H, Wang SE, ApRhys CM, Liao G, Fujimuro M, Farrell CJ, Huang J, Hayward SD, Hayward GS.

J Virol. 2003 Jan;77(2):1481-500.


p53-independent induction of G1 arrest and p21WAF1/CIP1 expression by ascofuranone, an isoprenoid antibiotic, through downregulation of c-Myc.

Jeong JH, Kang SS, Park KK, Chang HW, Magae J, Chang YC.

Mol Cancer Ther. 2010 Jul;9(7):2102-13. doi: 10.1158/1535-7163.MCT-09-1159. Epub 2010 Jun 29.


F9 embryonal carcinoma cells fail to stop at G1/S boundary of the cell cycle after gamma-irradiation due to p21WAF1/CIP1 degradation.

Malashicheva AB, Kislyakova TV, Aksenov ND, Osipov KA, Pospelov VA.

Oncogene. 2000 Aug 10;19(34):3858-65.


Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways.

Tanaka T, Iino M.

Cell Signal. 2015 Jun;27(6):1110-9. doi: 10.1016/j.cellsig.2015.02.015. Epub 2015 Feb 26.


p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells.

Roy S, Kaur M, Agarwal C, Tecklenburg M, Sclafani RA, Agarwal R.

Mol Cancer Ther. 2007 Oct;6(10):2696-707.


H2O2 induces a transient multi-phase cell cycle arrest in mouse fibroblasts through modulating cyclin D and p21Cip1 expression.

Barnouin K, Dubuisson ML, Child ES, Fernandez de Mattos S, Glassford J, Medema RH, Mann DJ, Lam EW.

J Biol Chem. 2002 Apr 19;277(16):13761-70. Epub 2002 Feb 4.


The role of p21(CIP1/WAF1) in growth of epithelial cells exposed to hyperoxia.

Rancourt RC, Keng PC, Helt CE, O'Reilly MA.

Am J Physiol Lung Cell Mol Physiol. 2001 Apr;280(4):L617-26.


p21CDKN1A does not interfere with loading of PCNA at DNA replication sites, but inhibits subsequent binding of DNA polymerase delta at the G1/S phase transition.

Cazzalini O, Perucca P, Riva F, Stivala LA, Bianchi L, Vannini V, Ducommun B, Prosperi E.

Cell Cycle. 2003 Nov-Dec;2(6):596-603.


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