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Items: 1 to 20 of 121

1.

An antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy.

Lach-Trifilieff E, Minetti GC, Sheppard K, Ibebunjo C, Feige JN, Hartmann S, Brachat S, Rivet H, Koelbing C, Morvan F, Hatakeyama S, Glass DJ.

Mol Cell Biol. 2014 Feb;34(4):606-18. doi: 10.1128/MCB.01307-13. Epub 2013 Dec 2.

2.

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size.

Trendelenburg AU, Meyer A, Rohner D, Boyle J, Hatakeyama S, Glass DJ.

Am J Physiol Cell Physiol. 2009 Jun;296(6):C1258-70. doi: 10.1152/ajpcell.00105.2009. Epub 2009 Apr 8.

3.

PI3 kinase regulation of skeletal muscle hypertrophy and atrophy.

Glass DJ.

Curr Top Microbiol Immunol. 2010;346:267-78. doi: 10.1007/82_2010_78. Review.

PMID:
20593312
4.

Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway.

Lee SJ, Huynh TV, Lee YS, Sebald SM, Wilcox-Adelman SA, Iwamori N, Lepper C, Matzuk MM, Fan CM.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2353-60. doi: 10.1073/pnas.1206410109. Epub 2012 Aug 6.

5.

Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators.

Souza TA, Chen X, Guo Y, Sava P, Zhang J, Hill JJ, Yaworsky PJ, Qiu Y.

Mol Endocrinol. 2008 Dec;22(12):2689-702. doi: 10.1210/me.2008-0290. Epub 2008 Oct 16.

PMID:
18927237
6.

Myostatin is a novel tumoral factor that induces cancer cachexia.

Lokireddy S, Wijesoma IW, Bonala S, Wei M, Sze SK, McFarlane C, Kambadur R, Sharma M.

Biochem J. 2012 Aug 15;446(1):23-36. doi: 10.1042/BJ20112024. Erratum in: Biochem J. 2015 Feb 15;466(1):201. Retraction in: Lokireddy S, Wijesoma IW, Bonala S, Wei M, Sze SK, McFarlane C, Kambadur R, Sharma M. Biochem J. 2016 Apr 15;473(8):1111.

7.

An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors.

Harrison CA, Gray PC, Fischer WH, Donaldson C, Choe S, Vale W.

J Biol Chem. 2004 Jul 2;279(27):28036-44. Epub 2004 Apr 27.

8.

The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy.

Ohsawa Y, Takayama K, Nishimatsu S, Okada T, Fujino M, Fukai Y, Murakami T, Hagiwara H, Itoh F, Tsuchida K, Hayashi Y, Sunada Y.

PLoS One. 2015 Jul 30;10(7):e0133713. doi: 10.1371/journal.pone.0133713. eCollection 2015.

9.

Treatment of sporadic inclusion body myositis with bimagrumab.

Amato AA, Sivakumar K, Goyal N, David WS, Salajegheh M, Praestgaard J, Lach-Trifilieff E, Trendelenburg AU, Laurent D, Glass DJ, Roubenoff R, Tseng BS, Greenberg SA.

Neurology. 2014 Dec 9;83(24):2239-46. doi: 10.1212/WNL.0000000000001070. Epub 2014 Nov 7.

10.

Overexpression of caveolin-3-enhanced protein synthesis rather than proteolysis inhibition in C2C12 myoblasts: relationship with myostatin activity.

Hadj Sassi A, Monteil J, Sauvant P, Atgié C.

J Physiol Biochem. 2012 Dec;68(4):683-90. doi: 10.1007/s13105-012-0192-9. Epub 2012 Jul 12.

PMID:
22791505
11.

Elevated expression of activins promotes muscle wasting and cachexia.

Chen JL, Walton KL, Winbanks CE, Murphy KT, Thomson RE, Makanji Y, Qian H, Lynch GS, Harrison CA, Gregorevic P.

FASEB J. 2014 Apr;28(4):1711-23. doi: 10.1096/fj.13-245894. Epub 2013 Dec 30.

12.

Smad2 and 3 transcription factors control muscle mass in adulthood.

Sartori R, Milan G, Patron M, Mammucari C, Blaauw B, Abraham R, Sandri M.

Am J Physiol Cell Physiol. 2009 Jun;296(6):C1248-57. doi: 10.1152/ajpcell.00104.2009. Epub 2009 Apr 8.

13.

Regulation of muscle growth by multiple ligands signaling through activin type II receptors.

Lee SJ, Reed LA, Davies MV, Girgenrath S, Goad ME, Tomkinson KN, Wright JF, Barker C, Ehrmantraut G, Holmstrom J, Trowell B, Gertz B, Jiang MS, Sebald SM, Matzuk M, Li E, Liang LF, Quattlebaum E, Stotish RL, Wolfman NM.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18117-22. Epub 2005 Dec 5.

14.

Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells.

Bowser M, Herberg S, Arounleut P, Shi X, Fulzele S, Hill WD, Isales CM, Hamrick MW.

Exp Gerontol. 2013 Feb;48(2):290-7. doi: 10.1016/j.exger.2012.11.004. Epub 2012 Nov 21.

15.

Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β.

Ungefroren H, Hyder A, Hinz H, Groth S, Lange H, El-Sayed KM, Ehnert S, Nüssler AK, Fändrich F, Gieseler F.

PLoS One. 2015 Feb 23;10(2):e0118097. doi: 10.1371/journal.pone.0118097. eCollection 2015.

16.

Myostatin/activin pathway antagonism: molecular basis and therapeutic potential.

Han HQ, Zhou X, Mitch WE, Goldberg AL.

Int J Biochem Cell Biol. 2013 Oct;45(10):2333-47. doi: 10.1016/j.biocel.2013.05.019. Epub 2013 May 28. Review.

PMID:
23721881
17.

Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting.

Lokireddy S, McFarlane C, Ge X, Zhang H, Sze SK, Sharma M, Kambadur R.

Mol Endocrinol. 2011 Nov;25(11):1936-49. doi: 10.1210/me.2011-1124. Epub 2011 Sep 29. Erratum in: Mol Endocrinol. 2015 Jan;29(1):153. Retraction in: Mol Endocrinol. 2016 Feb;30(2):274.

PMID:
21964591
18.

An inhibitor of transforming growth factor beta type I receptor ameliorates muscle atrophy in a mouse model of caveolin 3-deficient muscular dystrophy.

Ohsawa Y, Okada T, Nishimatsu S, Ishizaki M, Suga T, Fujino M, Murakami T, Uchino M, Tsuchida K, Noji S, Hinohara A, Shimizu T, Shimizu K, Sunada Y.

Lab Invest. 2012 Aug;92(8):1100-14. doi: 10.1038/labinvest.2012.78. Epub 2012 May 14.

19.

Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism.

Fournier B, Murray B, Gutzwiller S, Marcaletti S, Marcellin D, Bergling S, Brachat S, Persohn E, Pierrel E, Bombard F, Hatakeyama S, Trendelenburg AU, Morvan F, Richardson B, Glass DJ, Lach-Trifilieff E, Feige JN.

Mol Cell Biol. 2012 Jul;32(14):2871-9. doi: 10.1128/MCB.06575-11. Epub 2012 May 14.

20.

Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin/activin-blocked mdx mice.

Hulmi JJ, Oliveira BM, Silvennoinen M, Hoogaars WM, Pasternack A, Kainulainen H, Ritvos O.

Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E171-82. doi: 10.1152/ajpendo.00065.2013. Epub 2013 May 21.

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