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Withaferin A inhibits experimental epithelial-mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors.

Lee J, Hahm ER, Marcus AI, Singh SV.

Mol Carcinog. 2015 Jun;54(6):417-29. doi: 10.1002/mc.22110. Epub 2013 Nov 30.


Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells.

Sehrawat A, Singh SV.

Cancer Prev Res (Phila). 2011 Jul;4(7):1107-17. doi: 10.1158/1940-6207.CAPR-10-0306. Epub 2011 Apr 4.


Withaferin a suppresses estrogen receptor-α expression in human breast cancer cells.

Hahm ER, Lee J, Huang Y, Singh SV.

Mol Carcinog. 2011 Aug;50(8):614-24. doi: 10.1002/mc.20760. Epub 2011 Mar 22.


Autophagy fails to alter withaferin A-mediated lethality in human breast cancer cells.

Hahm ER, Singh SV.

Curr Cancer Drug Targets. 2013 Jul;13(6):640-50.


Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo.

Stan SD, Hahm ER, Warin R, Singh SV.

Cancer Res. 2008 Sep 15;68(18):7661-9. doi: 10.1158/0008-5472.CAN-08-1510.


Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells.

Lee J, Hahm ER, Singh SV.

Carcinogenesis. 2010 Nov;31(11):1991-8. doi: 10.1093/carcin/bgq175. Epub 2010 Aug 19.


Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin.

Antony ML, Lee J, Hahm ER, Kim SH, Marcus AI, Kumari V, Ji X, Yang Z, Vowell CL, Wipf P, Uechi GT, Yates NA, Romero G, Sarkar SN, Singh SV.

J Biol Chem. 2014 Jan 17;289(3):1852-65. doi: 10.1074/jbc.M113.496844. Epub 2013 Dec 2.


Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression.

Hahm ER, Singh SV.

Cancer Lett. 2013 Jun 28;334(1):101-8. doi: 10.1016/j.canlet.2012.08.026. Epub 2012 Aug 27.


Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species.

Hahm ER, Moura MB, Kelley EE, Van Houten B, Shiva S, Singh SV.

PLoS One. 2011;6(8):e23354. doi: 10.1371/journal.pone.0023354. Epub 2011 Aug 10.


Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cells.

Lee J, Sehrawat A, Singh SV.

Breast Cancer Res Treat. 2012 Nov;136(1):45-56. doi: 10.1007/s10549-012-2239-6. Epub 2012 Sep 11.


The monoamine oxidase-A inhibitor clorgyline promotes a mesenchymal-to-epithelial transition in the MDA-MB-231 breast cancer cell line.

Satram-Maharaj T, Nyarko JN, Kuski K, Fehr K, Pennington PR, Truitt L, Freywald A, Lukong KE, Anderson DH, Mousseau DD.

Cell Signal. 2014 Dec;26(12):2621-32. doi: 10.1016/j.cellsig.2014.08.005. Epub 2014 Aug 22.


Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition.

Yang Z, Garcia A, Xu S, Powell DR, Vertino PM, Singh S, Marcus AI.

PLoS One. 2013 Sep 12;8(9):e75069. doi: 10.1371/journal.pone.0075069. eCollection 2013.


Mammary cancer chemoprevention by withaferin A is accompanied by in vivo suppression of self-renewal of cancer stem cells.

Kim SH, Singh SV.

Cancer Prev Res (Phila). 2014 Jul;7(7):738-47. doi: 10.1158/1940-6207.CAPR-13-0445. Epub 2014 May 13.


Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells.

Sehrawat A, Kim SH, Vogt A, Singh SV.

Carcinogenesis. 2013 Apr;34(4):864-73. doi: 10.1093/carcin/bgs397. Epub 2012 Dec 30.


Pharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells.

Szarc vel Szic K, Op de Beeck K, Ratman D, Wouters A, Beck IM, Declerck K, Heyninck K, Fransen E, Bracke M, De Bosscher K, Lardon F, Van Camp G, Vanden Berghe W.

PLoS One. 2014 Feb 3;9(2):e87850. doi: 10.1371/journal.pone.0087850. eCollection 2014.


Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells.

Hahm ER, Lee J, Singh SV.

Mol Carcinog. 2014 Nov;53(11):907-16. doi: 10.1002/mc.22050. Epub 2013 Sep 9.


Combinatorial TGF-β attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells.

Park SY, Kim MJ, Park SA, Kim JS, Min KN, Kim DK, Lim W, Nam JS, Sheen YY.

Oncotarget. 2015 Nov 10;6(35):37526-43. doi: 10.18632/oncotarget.6063.


γ-Tocotrienol reversal of epithelial-to-mesenchymal transition in human breast cancer cells is associated with inhibition of canonical Wnt signalling.

Ahmed RA, Alawin OA, Sylvester PW.

Cell Prolif. 2016 Aug;49(4):460-70. doi: 10.1111/cpr.12270. Epub 2016 Jun 21.


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