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Items: 1 to 20 of 35

1.

(S)-tetrahydroisoquinoline alkaloid inhibits LPS-induced arachidonic acid release through downregulation of cPLA2 expression.

Choi JM, Choi YH, Kim SK, Ahn KH, Won JH, Lim JH, Jang YJ, Lee S, Kim DH, Kim DK.

Mol Cells. 2013 Nov;36(5):400-9. doi: 10.1007/s10059-013-0078-x. Epub 2013 Nov 14.

2.

CKD712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, inhibits the lipopolysaccharide-stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C.

Oh YJ, Youn JH, Min HJ, Kim DH, Lee SS, Choi IH, Shin JS.

Int Immunopharmacol. 2011 Sep;11(9):1160-5. doi: 10.1016/j.intimp.2011.03.013. Epub 2011 Mar 30.

PMID:
21457762
3.

Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide-induced VCAM-1 but not ICAM-1 expression in human endothelial cells.

Tsoyi K, Kim WS, Kim YM, Kim HJ, Seo HG, Lee JH, Yun-Choi HS, Chang KC.

Atherosclerosis. 2009 Dec;207(2):412-9. doi: 10.1016/j.atherosclerosis.2009.05.012. Epub 2009 May 21.

PMID:
19540498
4.

Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways.

Jang SI, Kim HJ, Kim YJ, Jeong SI, You YO.

Eur J Pharmacol. 2006 Aug 7;542(1-3):1-7. Epub 2006 May 6.

PMID:
16797002
5.
6.

Involvement of MAPKs, NF-kappaB and p300 co-activator in IL-1beta-induced cytosolic phospholipase A2 expression in canine tracheal smooth muscle cells.

Luo SF, Lin CC, Chen HC, Lin WN, Lee IT, Lee CW, Hsiao LD, Yang CM.

Toxicol Appl Pharmacol. 2008 Nov 1;232(3):396-407. doi: 10.1016/j.taap.2008.07.019. Epub 2008 Jul 29.

PMID:
18708082
7.

CKD712, a synthetic isoquinoline alkaloid, enhances the anti-cancer effects of paclitaxel in MDA-MB-231 cells through regulation of PTEN.

Kim YM, Tsoyi K, Jang HJ, Park EJ, Park SW, Kim HJ, Hwa JS, Chang KC.

Life Sci. 2014 Sep 1;112(1-2):49-58. doi: 10.1016/j.lfs.2014.07.015. Epub 2014 Jul 21.

PMID:
25058922
9.

Acetate reduces PGE2 release and modulates phospholipase and cyclooxygenase levels in neuroglia stimulated with lipopolysaccharide.

Soliman ML, Ohm JE, Rosenberger TA.

Lipids. 2013 Jul;48(7):651-62. doi: 10.1007/s11745-013-3799-x. Epub 2013 May 25.

11.

(S)-1-α-naphthylmethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712), promotes wound closure by producing VEGF through HO-1 induction in human dermal fibroblasts and mouse skin.

Jang HJ, Tsoyi K, Kim YM, Park EJ, Park SW, Kim HJ, Lee JH, Chang KC.

Br J Pharmacol. 2013 Mar;168(6):1485-96. doi: 10.1111/bph.12031.

13.

Arachidonic acid release by H2O2 mediated proliferation of mouse embryonic stem cells: involvement of Ca2+/PKC and MAPKs-induced EGFR transactivation.

Lee SH, Na SI, Heo JS, Kim MH, Kim YH, Lee MY, Kim SH, Lee YJ, Han HJ.

J Cell Biochem. 2009 Apr 1;106(5):787-97. doi: 10.1002/jcb.22013.

PMID:
19199341
15.

Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-kappaB in human tracheal smooth muscle cells.

Cheng SE, Luo SF, Jou MJ, Lin CC, Kou YR, Lee IT, Hsieh HL, Yang CM.

Free Radic Biol Med. 2009 Apr 1;46(7):948-60.

PMID:
19280714
16.

Modulation of arachidonic acid metabolism and nitric oxide synthesis by garcinol and its derivatives.

Hong J, Sang S, Park HJ, Kwon SJ, Suh N, Huang MT, Ho CT, Yang CS.

Carcinogenesis. 2006 Feb;27(2):278-86. Epub 2005 Aug 10.

PMID:
16093250
17.
18.

A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-κB signaling and improves survival in mouse models of sepsis.

Fang JP, Liu Y, Li J, Liao WF, Hu YH, Ding K.

Acta Pharmacol Sin. 2012 Sep;33(9):1204-16. doi: 10.1038/aps.2012.56. Epub 2012 Jun 11.

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