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Items: 1 to 20 of 125

1.

Synthesis and structure-activity relationships of novel zwitterionic compounds as peroxisome proliferator activated receptor α/γ dual agonists with improved physicochemical properties.

Shibata Y, Kagechika K, Yamaguchi M, Yoshikawa K, Chiba K, Takano H, Akiyama C, Ono M, Nishi M, Kubo H, Kobayashi Y, Usui H.

Chem Pharm Bull (Tokyo). 2013;61(12):1248-63.

2.

Synthesis and Structure-Activity Relationships of 2-Aminoacetamide Derivatives as Peroxisome Proliferator-Activated Receptor α/γ Dual Agonists.

Shibata Y, Kagechika K, Ota M, Yamaguchi M, Setoguchi M, Kubo H, Chiba K, Takano H, Akiyama C, Ono M, Nishi M, Usui H.

Chem Pharm Bull (Tokyo). 2015;63(8):591-602. doi: 10.1248/cpb.c15-00221.

3.

Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1).

Shibata Y, Kagechika K, Yamaguchi M, Kubo H, Usui H.

Bioorg Med Chem Lett. 2012 Dec 1;22(23):7075-9. doi: 10.1016/j.bmcl.2012.09.092. Epub 2012 Oct 2.

PMID:
23084275
4.

Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.

Zhang H, Ding CZ, Lai Z, Chen SS, Devasthale P, Herpin T, Morton G, Qu F, Ryono D, Smirk R, Wang W, Wu S, Ye XX, Li YX, Apedo A, Farrelly D, Wang T, Gu L, Morgan N, Flynn N, Chu C, Kunselman L, Lippy J, Locke K, O'Malley K, Harrity T, Cap M, Zhang L, Hosagrahara V, Kadiyala P, Xu C, Doweyko AM, Zahler R, Hariharan N, Cheng PT.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1196-205. doi: 10.1016/j.bmcl.2015.01.066. Epub 2015 Feb 4.

PMID:
25686852
5.

[Design, synthesis, and PPARalpha/gamma agonistic activity of novel tetrahydroisoquinoline derivatives].

Yu R, Zhou YL, Huan Y, Liu Q, Shen ZF, Liu ZZ.

Yao Xue Xue Bao. 2011 Mar;46(3):311-6. Chinese.

PMID:
21626786
6.

Potent anti-diabetic effects of MHY908, a newly synthesized PPAR α/γ dual agonist in db/db mice.

Park MH, Park JY, Lee HJ, Kim DH, Park D, Jeong HO, Park CH, Chun P, Moon HR, Chung HY.

PLoS One. 2013 Nov 14;8(11):e78815. doi: 10.1371/journal.pone.0078815. eCollection 2013.

7.

Discovery of thiazolidine-2,4-dione/biphenylcarbonitrile hybrid as dual PPAR α/γ modulator with antidiabetic effect: in vitro, in silico and in vivo approaches.

Hidalgo-Figueroa S, Ramírez-Espinosa JJ, Estrada-Soto S, Almanza-Pérez JC, Román-Ramos R, Alarcón-Aguilar FJ, Hernández-Rosado JV, Moreno-Díaz H, Díaz-Coutiño D, Navarrete-Vázquez G.

Chem Biol Drug Des. 2013 Apr;81(4):474-83. doi: 10.1111/cbdd.12102. Epub 2013 Mar 21.

PMID:
23289972
8.

Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.

Humphries PS, Almaden JV, Barnum SJ, Carlson TJ, Do QQ, Fraser JD, Hess M, Kim YH, Ogilvie KM, Sun S.

Bioorg Med Chem Lett. 2006 Dec 1;16(23):6116-9. Epub 2006 Sep 18.

PMID:
16979341
9.

Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia.

Liu K, Xu L, Berger JP, Macnaul KL, Zhou G, Doebber TW, Forrest MJ, Moller DE, Jones AB.

J Med Chem. 2005 Apr 7;48(7):2262-5.

PMID:
15801817
10.

Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.

Pingali H, Jain M, Shah S, Makadia P, Zaware P, Goel A, Patel M, Giri S, Patel H, Patel P.

Bioorg Med Chem. 2008 Aug 1;16(15):7117-27. doi: 10.1016/j.bmc.2008.06.050. Epub 2008 Jun 28.

PMID:
18625559
11.
12.

Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.

Humphries PS, Bailey S, Almaden JV, Barnum SJ, Carlson TJ, Christie LC, Do QQ, Fraser JD, Hess M, Kellum J, Kim YH, McClellan GA, Ogilvie KM, Simmons BH, Skalitzky D, Sun S, Wilhite D, Zehnder LR.

Bioorg Med Chem Lett. 2006 Dec 1;16(23):6120-3. Epub 2006 Sep 14.

PMID:
16973358
13.

Indanylacetic acid derivatives carrying 4-thiazolyl-phenoxy tail groups, a new class of potent PPAR alpha/gamma/delta pan agonists: synthesis, structure-activity relationship, and in vivo efficacy.

Rudolph J, Chen L, Majumdar D, Bullock WH, Burns M, Claus T, Dela Cruz FE, Daly M, Ehrgott FJ, Johnson JS, Livingston JN, Schoenleber RW, Shapiro J, Yang L, Tsutsumi M, Ma X.

J Med Chem. 2007 Mar 8;50(5):984-1000. Epub 2007 Feb 3.

PMID:
17274610
14.

Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARalpha/gamma dual agonists.

Kim E, Park CS, Han T, Bae MH, Chong W, Lee CH, Shin YA, Ahn BN, Kim MK, Shin CY, Son MH, Kim JK, Moon HS, Shim HJ, Kim EJ, Kim SH, Lim JI, Lee CH.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):4993-6. doi: 10.1016/j.bmcl.2008.08.020. Epub 2008 Aug 12.

PMID:
18771917
15.

Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.

Zhang H, Ryono DE, Devasthale P, Wang W, O'Malley K, Farrelly D, Gu L, Harrity T, Cap M, Chu C, Locke K, Zhang L, Lippy J, Kunselman L, Morgan N, Flynn N, Moore L, Hosagrahara V, Zhang L, Kadiyala P, Xu C, Doweyko AM, Bell A, Chang C, Muckelbauer J, Zahler R, Hariharan N, Cheng PT.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1451-6. doi: 10.1016/j.bmcl.2009.01.030. Epub 2009 Jan 15.

PMID:
19201606
16.

Antidiabetic and hypolipidemic effects of a novel dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, E3030, in db/db mice and beagle dogs.

Kasai S, Inoue T, Yoshitomi H, Hihara T, Matsuura F, Harada H, Shinoda M, Tanaka I.

J Pharmacol Sci. 2008 Sep;108(1):40-8. Epub 2008 Sep 6.

17.

A newly identified CG301269 improves lipid and glucose metabolism without body weight gain through activation of peroxisome proliferator-activated receptor alpha and gamma.

Jeong HW, Lee JW, Kim WS, Choe SS, Kim KH, Park HS, Shin HJ, Lee GY, Shin D, Lee H, Lee JH, Choi EB, Lee HK, Chung H, Park SB, Park KS, Kim HS, Ro S, Kim JB.

Diabetes. 2011 Feb;60(2):496-506. doi: 10.2337/db09-1145.

18.

[Design, synthesis and antidiabetic activity of novel tetrahydrocarboline PPAR regulators].

Peng K, Huan Y, Liu Q, Shen ZF, Liu ZZ.

Yao Xue Xue Bao. 2014 Apr;49(4):490-6. Chinese.

PMID:
24974466
19.

Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.

Suh YG, Kim NJ, Koo BW, Lee KO, Moon SH, Shin DH, Jung JW, Paek SM, Chang DJ, Li F, Kang HJ, Le TV, Chae YN, Shin CY, Kim MK, Lim JI, Ryu JS, Park HJ.

J Med Chem. 2008 Oct 23;51(20):6318-33. doi: 10.1021/jm8003416. Epub 2008 Oct 1.

PMID:
18826205
20.

Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.

Devasthale PV, Chen S, Jeon Y, Qu F, Ryono DE, Wang W, Zhang H, Cheng L, Farrelly D, Golla R, Grover G, Ma Z, Moore L, Seethala R, Sun W, Doweyko AM, Chandrasena G, Sleph P, Hariharan N, Cheng PT.

Bioorg Med Chem Lett. 2007 Apr 15;17(8):2312-6. Epub 2007 Jan 25.

PMID:
17292606

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