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Items: 1 to 20 of 113

1.

eRapa restores a normal life span in a FAP mouse model.

Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, Fischer KE, Sloane L, Murthy K, Hubbard G, Sun L, Hurez V, Curiel TJ, Sharp ZD.

Cancer Prev Res (Phila). 2014 Jan;7(1):169-78. doi: 10.1158/1940-6207.CAPR-13-0299. Epub 2013 Nov 26.

2.

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish.

Valvezan AJ, Huang J, Lengner CJ, Pack M, Klein PS.

Dis Model Mech. 2014 Jan;7(1):63-71. doi: 10.1242/dmm.012625. Epub 2013 Oct 2.

3.

Effect of targeting janus kinase 3 on the development of intestinal tumors in the adenomatous polyposis coli(min) mouse model of familial adenomatous polyposis.

Uckun FM, Erbeck D, Qazi S, Venkatachalam T, Tibbles HE, Vassilev A.

Arzneimittelforschung. 2007;57(6):320-9.

PMID:
17688077
4.

Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors.

Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, Strong R, Bokov A, Javors MA, Ikeno Y, Hubbard G, Hasty P, Sharp ZD.

Aging (Albany NY). 2013 Feb;5(2):100-10.

5.

Chronic mechanistic target of rapamycin inhibition: preventing cancer to delay aging, or vice versa?.

Sharp ZD, Curiel TJ, Livi CB.

Interdiscip Top Gerontol. 2013;38:1-16. doi: 10.1159/000343625. Epub 2013 Jan 17. Review.

PMID:
23503511
6.

Chemoprevention of familial adenomatous polyposis development in the APC(min) mouse model by 1,4-phenylene bis(methylene)selenocyanate.

Rao CV, Cooma I, Rodriguez JG, Simi B, El-Bayoumy K, Reddy BS.

Carcinogenesis. 2000 Apr;21(4):617-21.

PMID:
10753194
7.

Apc mice: models, modifiers and mutants.

McCart AE, Vickaryous NK, Silver A.

Pathol Res Pract. 2008;204(7):479-90. doi: 10.1016/j.prp.2008.03.004. Epub 2008 Jun 5. Review.

PMID:
18538487
8.
9.

Chemoprevention of familial adenomatous polyposis by bromo-noscapine (EM011) in the Apc(Min/+) mouse model.

Li S, Ghaleb AM, He J, Bughani U, Bialkowska AB, Yang VW, Joshi HC.

Int J Cancer. 2012 Sep 15;131(6):1435-44. doi: 10.1002/ijc.27344. Epub 2012 Feb 9.

10.

Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC(Min/+) mice.

Koehl GE, Spitzner M, Ousingsawat J, Schreiber R, Geissler EK, Kunzelmann K.

Oncogene. 2010 Mar 11;29(10):1553-60. doi: 10.1038/onc.2009.435. Epub 2009 Dec 7.

PMID:
19966863
11.

The sulfide metabolite of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis.

Mahmoud NN, Boolbol SK, Dannenberg AJ, Mestre JR, Bilinski RT, Martucci C, Newmark HL, Chadburn A, Bertagnolli MM.

Carcinogenesis. 1998 Jan;19(1):87-91.

PMID:
9472698
12.

Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts.

Husøy T, Knutsen HK, Cruciani V, Olstørn HB, Mikalsen SO, Løberg EM, Alexander J.

Int J Cancer. 2005 Sep 1;116(3):351-8.

13.

The armadillo repeat domain of Apc suppresses intestinal tumorigenesis.

Crist RC, Roth JJ, Baran AA, McEntee BJ, Siracusa LD, Buchberg AM.

Mamm Genome. 2010 Oct;21(9-10):450-7. doi: 10.1007/s00335-010-9288-0. Epub 2010 Oct 1.

14.

Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice.

You S, Ohmori M, Peña MM, Nassri B, Quiton J, Al-Assad ZA, Liu L, Wood PA, Berger SH, Liu Z, Wyatt MD, Price RL, Berger FG, Hrushesky WJ.

Int J Exp Pathol. 2006 Jun;87(3):227-36.

15.

Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice.

Yamada Y, Hata K, Hirose Y, Hara A, Sugie S, Kuno T, Yoshimi N, Tanaka T, Mori H.

Cancer Res. 2002 Nov 15;62(22):6367-70.

16.

APC in the regulation of intestinal crypt fission.

Wasan HS, Park HS, Liu KC, Mandir NK, Winnett A, Sasieni P, Bodmer WF, Goodlad RA, Wright NA.

J Pathol. 1998 Jul;185(3):246-55.

PMID:
9771477
17.

R-flurbiprofen chemoprevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: implications for prophylaxis and treatment of colon cancer.

Wechter WJ, Kantoci D, Murray ED Jr, Quiggle DD, Leipold DD, Gibson KM, McCracken JD.

Cancer Res. 1997 Oct 1;57(19):4316-24.

18.

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, Jones C, Radulescu S, Huels DJ, Myant KB, Dudek KM, Casey HA, Scopelliti A, Cordero JB, Vidal M, Pende M, Ryazanov AG, Sonenberg N, Meyuhas O, Hall MN, Bushell M, Willis AE, Sansom OJ.

Nature. 2015 Jan 22;517(7535):497-500. doi: 10.1038/nature13896. Epub 2014 Nov 5.

19.

The genetic background of familial adenomatous polyposis. Linkage analysis, the APC gene identification and mutation screening.

Kartheuser A, West S, Walon C, Curtis A, Hamzehloei T, Lannoy N, Michiels G, Smaers M, Chapman P, Burn J, et al.

Acta Gastroenterol Belg. 1995 Sep-Dec;58(5-6):433-51. Review.

PMID:
8776001
20.

Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis.

Yang K, Edelmann W, Fan K, Lau K, Leung D, Newmark H, Kucherlapati R, Lipkin M.

Cancer Res. 1998 Dec 15;58(24):5713-7.

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