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Items: 1 to 20 of 126


Up-regulation of Gadd45α after exposure to metal nanoparticles: the role of hypoxia inducible factor 1α.

Feng L, Zhang Y, Jiang M, Mo Y, Wan R, Jia Z, Tollerud DJ, Zhang X, Zhang Q.

Environ Toxicol. 2015 Apr;30(4):490-9. doi: 10.1002/tox.21926. Epub 2013 Nov 26.


The role of hypoxia inducible factor-1α in the increased MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles.

Wan R, Mo Y, Chien S, Li Y, Li Y, Tollerud DJ, Zhang Q.

Nanotoxicology. 2011 Dec;5(4):568-82. doi: 10.3109/17435390.2010.537791. Epub 2011 Mar 14.


DNA damage caused by metal nanoparticles: involvement of oxidative stress and activation of ATM.

Wan R, Mo Y, Feng L, Chien S, Tollerud DJ, Zhang Q.

Chem Res Toxicol. 2012 Jul 16;25(7):1402-11. doi: 10.1021/tx200513t. Epub 2012 May 14.


Titanium nanoparticle inhalation induces renal fibrosis in mice via an oxidative stress upregulated transforming growth factor-β pathway.

Huang KT, Wu CT, Huang KH, Lin WC, Chen CM, Guan SS, Chiang CK, Liu SH.

Chem Res Toxicol. 2015 Mar 16;28(3):354-64. doi: 10.1021/tx500287f. Epub 2014 Dec 2.


Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1α.

Schilling D, Bayer C, Li W, Molls M, Vaupel P, Multhoff G.

PLoS One. 2012;7(2):e31110. doi: 10.1371/journal.pone.0031110. Epub 2012 Feb 7.


Importance of the HIF pathway in cobalt nanoparticle-induced cytotoxicity and inflammation in human macrophages.

Nyga A, Hart A, Tetley TD.

Nanotoxicology. 2015;9(7):905-17. doi: 10.3109/17435390.2014.991430. Epub 2015 Feb 13.


Cellular iron depletion and the mechanisms involved in the iron-dependent regulation of the growth arrest and DNA damage family of genes.

Saletta F, Suryo Rahmanto Y, Siafakas AR, Richardson DR.

J Biol Chem. 2011 Oct 14;286(41):35396-406. doi: 10.1074/jbc.M111.273060. Epub 2011 Aug 18.


Matrix metalloproteinase-2 and -9 are induced differently by metal nanoparticles in human monocytes: The role of oxidative stress and protein tyrosine kinase activation.

Wan R, Mo Y, Zhang X, Chien S, Tollerud DJ, Zhang Q.

Toxicol Appl Pharmacol. 2008 Dec 1;233(2):276-85. doi: 10.1016/j.taap.2008.08.022. Epub 2008 Sep 16.


Regulation of plasminogen activator inhibitor-1 expression in endothelial cells with exposure to metal nanoparticles.

Yu M, Mo Y, Wan R, Chien S, Zhang X, Zhang Q.

Toxicol Lett. 2010 May 19;195(1):82-9. doi: 10.1016/j.toxlet.2010.02.010. Epub 2010 Feb 18.


Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes.

Li Q, Chen H, Huang X, Costa M.

Toxicol Appl Pharmacol. 2006 Jun 15;213(3):245-55. Epub 2006 Jan 4.


Induction of the hypoxia-inducible factor system by low levels of heat shock protein 90 inhibitors.

Ibrahim NO, Hahn T, Franke C, Stiehl DP, Wirthner R, Wenger RH, Katschinski DM.

Cancer Res. 2005 Dec 1;65(23):11094-100.


Arsenite stabilizes HIF-1α protein through p85α-mediated up-regulation of inducible Hsp70 protein expression.

Guo W, Yang Z, Xia Q, Liu J, Yu Y, Li J, Zuo Z, Zhang D, Li X, Shi X, Huang C.

Cell Mol Life Sci. 2011 Feb;68(3):475-88. doi: 10.1007/s00018-010-0459-7. Epub 2010 Sep 12.


Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia.

Goda N, Ryan HE, Khadivi B, McNulty W, Rickert RC, Johnson RS.

Mol Cell Biol. 2003 Jan;23(1):359-69.


Hypoxia-inducible factor 1alpha and 1beta proteins share common signaling pathways in human prostate cancer cells.

Zhong H, Hanrahan C, van der Poel H, Simons JW.

Biochem Biophys Res Commun. 2001 Jun 8;284(2):352-6.


DNA-dependent protein kinase is involved in heat shock protein-mediated accumulation of hypoxia-inducible factor-1alpha in hypoxic preconditioned HepG2 cells.

Kang MJ, Jung SM, Kim MJ, Bae JH, Kim HB, Kim JY, Park SJ, Song HS, Kim DW, Kang CD, Kim SH.

FEBS J. 2008 Dec;275(23):5969-81. doi: 10.1111/j.1742-4658.2008.06725.x.


PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.

Zhou J, Schmid T, Frank R, Brüne B.

J Biol Chem. 2004 Apr 2;279(14):13506-13. Epub 2004 Jan 15.


Ηypoxia-inducible factor-1α, von Hippel-Lindau protein, and heat shock protein expression in ophthalmic pterygium and normal conjunctiva.

Pagoulatos D, Pharmakakis N, Lakoumentas J, Assimakopoulou M.

Mol Vis. 2014 Mar 30;20:441-57. eCollection 2014.


Hypoxia-inducible factor-1β (HIF-1β) is upregulated in a HIF-1α-dependent manner in 518A2 human melanoma cells under hypoxic conditions.

Mandl M, Kapeller B, Lieber R, Macfelda K.

Biochem Biophys Res Commun. 2013 Apr 26;434(1):166-72. doi: 10.1016/j.bbrc.2013.03.051. Epub 2013 Mar 26.


Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1alpha.

Kim WY, Oh SH, Woo JK, Hong WK, Lee HY.

Cancer Res. 2009 Feb 15;69(4):1624-32. doi: 10.1158/0008-5472.CAN-08-0505. Epub 2009 Jan 27.

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