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Items: 1 to 20 of 135

1.

Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.

Martín-Rufián M, Nascimento-Gomes R, Higuero A, Crisma AR, Campos-Sandoval JA, Gómez-García MC, Cardona C, Cheng T, Lobo C, Segura JA, Alonso FJ, Szeliga M, Albrecht J, Curi R, Márquez J, Colquhoun A, Deberardinis RJ, Matés JM.

J Mol Med (Berl). 2014 Mar;92(3):277-90. doi: 10.1007/s00109-013-1105-2. Epub 2013 Nov 26.

2.

Opposing roles of glutaminase isoforms in determining glioblastoma cell phenotype.

Szeliga M, Albrecht J.

Neurochem Int. 2015 Sep;88:6-9. doi: 10.1016/j.neuint.2014.11.004. Epub 2014 Dec 18. Review.

PMID:
25529918
3.

Silencing of GLS and overexpression of GLS2 genes cooperate in decreasing the proliferation and viability of glioblastoma cells.

Szeliga M, Bogacińska-Karaś M, Różycka A, Hilgier W, Marquez J, Albrecht J.

Tumour Biol. 2014 Mar;35(3):1855-62. doi: 10.1007/s13277-013-1247-4. Epub 2013 Oct 6.

4.

Glutaminase isoenzymes as key regulators in metabolic and oxidative stress against cancer.

Matés JM, Segura JA, Martín-Rufián M, Campos-Sandoval JA, Alonso FJ, Márquez J.

Curr Mol Med. 2013 May;13(4):514-34. Review.

PMID:
22934847
5.

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species.

Suzuki S, Tanaka T, Poyurovsky MV, Nagano H, Mayama T, Ohkubo S, Lokshin M, Hosokawa H, Nakayama T, Suzuki Y, Sugano S, Sato E, Nagao T, Yokote K, Tatsuno I, Prives C.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7461-6. doi: 10.1073/pnas.1002459107. Epub 2010 Mar 29.

6.

Arsenic trioxide-induced cytotoxicity in small cell lung cancer via altered redox homeostasis and mitochondrial integrity.

Zheng CY, Lam SK, Li YY, Ho JC.

Int J Oncol. 2015 Mar;46(3):1067-78. doi: 10.3892/ijo.2015.2826. Epub 2015 Jan 9.

PMID:
25572414
7.

Multifunctional antitumor molecule 5'-triphosphate siRNA combining glutaminase silencing and RIG-I activation.

Meng G, Xia M, Xu C, Yuan D, Schnurr M, Wei J.

Int J Cancer. 2014 Apr 15;134(8):1958-71. doi: 10.1002/ijc.28416. Epub 2013 Dec 2.

8.

Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation.

Xiang L, Xie G, Liu C, Zhou J, Chen J, Yu S, Li J, Pang X, Shi H, Liang H.

Biochim Biophys Acta. 2013 Dec;1833(12):2996-3005. doi: 10.1016/j.bbamcr.2013.08.003. Epub 2013 Aug 13.

9.

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function.

Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7455-60. doi: 10.1073/pnas.1001006107. Epub 2010 Apr 8.

10.

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells.

Lee YZ, Yang CW, Chang HY, Hsu HY, Chen IS, Chang HS, Lee CH, Lee JC, Kumar CR, Qiu YQ, Chao YS, Lee SJ.

Oncotarget. 2014 Aug 15;5(15):6087-101.

11.

Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: a role of Bcl-2.

Gupta S, Yel L, Kim D, Kim C, Chiplunkar S, Gollapudi S.

Mol Cancer Ther. 2003 Aug;2(8):711-9.

12.

Elimination of the differential chemoresistance between the murine B-cell lymphoma LY-ar and LY-as cell lines after arsenic (As2O3) exposure via the overexpression of gsto1 (p28).

Giri U, Terry NH, Kala SV, Lieberman MW, Story MD.

Cancer Chemother Pharmacol. 2005 Jun;55(6):511-21. Epub 2005 Mar 11.

PMID:
15761769
13.
14.

Glutaminases in slowly proliferating gastroenteropancreatic neuroendocrine neoplasms/tumors (GEP-NETs): Selective overexpression of mRNA coding for the KGA isoform.

Szeliga M, Ćwikła J, Obara-Michlewska M, Cichocki A, Albrecht J.

Exp Mol Pathol. 2016 Feb;100(1):74-8. doi: 10.1016/j.yexmp.2015.11.017. Epub 2015 Nov 12.

PMID:
26581715
15.
16.

Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation.

Calviño E, Estañ MC, Simón GP, Sancho P, Boyano-Adánez Mdel C, de Blas E, Bréard J, Aller P.

Biochem Pharmacol. 2011 Dec 1;82(11):1619-29. doi: 10.1016/j.bcp.2011.08.017. Epub 2011 Aug 27.

PMID:
21889928
17.

Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1.

Wang R, Liu C, Xia L, Zhao G, Gabrilove J, Waxman S, Jing Y.

Clin Cancer Res. 2012 Dec 15;18(24):6690-701. doi: 10.1158/1078-0432.CCR-12-0770. Epub 2012 Oct 18.

18.

ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction underlie apoptosis induced by resveratrol and arsenic trioxide in A549 cells.

Gu S, Chen C, Jiang X, Zhang Z.

Chem Biol Interact. 2016 Feb 5;245:100-9. doi: 10.1016/j.cbi.2016.01.005. Epub 2016 Jan 6.

PMID:
26772155
19.

Arsenic trioxide induces autophagy and apoptosis in human glioma cells in vitro and in vivo through downregulation of survivin.

Chiu HW, Ho YS, Wang YJ.

J Mol Med (Berl). 2011 Sep;89(9):927-41. doi: 10.1007/s00109-011-0763-1. Epub 2011 May 19.

PMID:
21594580
20.

Mulberry fruit (Moris fructus) extracts induce human glioma cell death in vitro through ROS-dependent mitochondrial pathway and inhibits glioma tumor growth in vivo.

Jeong JC, Jang SW, Kim TH, Kwon CH, Kim YK.

Nutr Cancer. 2010;62(3):402-12. doi: 10.1080/01635580903441287.

PMID:
20358478

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