Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 132


The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.

Koenig A, Buskiewicz IA, Fortner KA, Russell JQ, Asaoka T, He YW, Hakem R, Eriksson JE, Budd RC.

J Biol Chem. 2014 Jan 10;289(2):1183-91. doi: 10.1074/jbc.M113.506428. Epub 2013 Nov 25.


The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways.

Kataoka T, Budd RC, Holler N, Thome M, Martinon F, Irmler M, Burns K, Hahne M, Kennedy N, Kovacsovics M, Tschopp J.

Curr Biol. 2000 Jun 1;10(11):640-8.


Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation.

Dohrman A, Kataoka T, Cuenin S, Russell JQ, Tschopp J, Budd RC.

J Immunol. 2005 May 1;174(9):5270-8.


Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.

Misra RS, Russell JQ, Koenig A, Hinshaw-Makepeace JA, Wen R, Wang D, Huo H, Littman DR, Ferch U, Ruland J, Thome M, Budd RC.

J Biol Chem. 2007 Jul 6;282(27):19365-74. Epub 2007 Apr 26.


c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival.

Hinshaw-Makepeace J, Huston G, Fortner KA, Russell JQ, Holoch D, Swain S, Budd RC.

Eur J Immunol. 2008 Jan;38(1):54-63.


c-FLIP-Short reduces type I interferon production and increases viremia with coxsackievirus B3.

Buskiewicz IA, Koenig A, Roberts B, Russell J, Shi C, Lee SH, Jung JU, Huber SA, Budd RC.

PLoS One. 2014 May 9;9(5):e96156. doi: 10.1371/journal.pone.0096156. eCollection 2014.


TNFα induces survival through the FLIP-L-dependent activation of the MAPK/ERK pathway.

Marques-Fernandez F, Planells-Ferrer L, Gozzelino R, Galenkamp KM, Reix S, Llecha-Cano N, Lopez-Soriano J, Yuste VJ, Moubarak RS, Comella JX.

Cell Death Dis. 2013 Feb 14;4:e493. doi: 10.1038/cddis.2013.25.


A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes.

He MX, He YW.

Cell Death Differ. 2013 Feb;20(2):188-97. doi: 10.1038/cdd.2012.148. Epub 2012 Nov 23.


In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8.

Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL.

J Biol Chem. 2011 Apr 15;286(15):13282-91. doi: 10.1074/jbc.M110.216226. Epub 2011 Feb 21. Erratum in: J Biol Chem. 2016 Jan 29;291(5):2547.


RIP1 Cleavage in the Kinase Domain Regulates TRAIL-Induced NF-κB Activation and Lymphoma Survival.

Zhang L, Blackwell K, Workman LM, Chen S, Pope MR, Janz S, Habelhah H.

Mol Cell Biol. 2015 Oct;35(19):3324-38. doi: 10.1128/MCB.00692-15. Epub 2015 Jul 20.


Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8.

Dohrman A, Russell JQ, Cuenin S, Fortner K, Tschopp J, Budd RC.

J Immunol. 2005 Jul 1;175(1):311-8.


DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas.

Bellail AC, Tse MC, Song JH, Phuphanich S, Olson JJ, Sun SY, Hao C.

J Cell Mol Med. 2010 Jun;14(6A):1303-17. doi: 10.1111/j.1582-4934.2009.00777.x. Epub 2009 May 11.


C/EBPbeta associates with caspase 8 complex proteins and modulates apoptosis in hepatic stellate cells.

Buck M, Chojkier M.

J Clin Gastroenterol. 2007 Nov-Dec;41 Suppl 3:S295-9.


NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2.

Diessenbacher P, Hupe M, Sprick MR, Kerstan A, Geserick P, Haas TL, Wachter T, Neumann M, Walczak H, Silke J, Leverkus M.

J Invest Dermatol. 2008 May;128(5):1134-47. Epub 2007 Nov 8.


RIP-1/c-FLIPL Induce Hepatic Cancer Cell Apoptosis Through Regulating Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL).

Sun J, Yu X, Wang C, Yu C, Li Z, Nie W, Xu X, Miao X, Jin X.

Med Sci Monit. 2017 Mar 8;23:1190-1199.


Catalytically active Yersinia outer protein P induces cleavage of RIP and caspase-8 at the level of the DISC independently of death receptors in dendritic cells.

Gröbner S, Adkins I, Schulz S, Richter K, Borgmann S, Wesselborg S, Ruckdeschel K, Micheau O, Autenrieth IB.

Apoptosis. 2007 Oct;12(10):1813-25.


Supplemental Content

Support Center