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Arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair.

Sun X, Zhou X, Du L, Liu W, Liu Y, Hudson LG, Liu KJ.

Toxicol Appl Pharmacol. 2014 Jan 15;274(2):313-8. doi: 10.1016/j.taap.2013.11.010. Epub 2013 Nov 22.


Inhibition of poly(ADP-ribose) polymerase-1 by arsenite interferes with repair of oxidative DNA damage.

Ding W, Liu W, Cooper KL, Qin XJ, de Souza Bergo PL, Hudson LG, Liu KJ.

J Biol Chem. 2009 Mar 13;284(11):6809-17. doi: 10.1074/jbc.M805566200. Epub 2008 Dec 3.


Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity.

Qin XJ, Hudson LG, Liu W, Timmins GS, Liu KJ.

Toxicol Appl Pharmacol. 2008 Oct 1;232(1):41-50. doi: 10.1016/j.taap.2008.05.019. Epub 2008 Jul 10.


Dual actions involved in arsenite-induced oxidative DNA damage.

Qin XJ, Hudson LG, Liu W, Ding W, Cooper KL, Liu KJ.

Chem Res Toxicol. 2008 Sep;21(9):1806-13. doi: 10.1021/tx8001548. Epub 2008 Aug 16.


Reduction of arsenite-enhanced ultraviolet radiation-induced DNA damage by supplemental zinc.

Cooper KL, King BS, Sandoval MM, Liu KJ, Hudson LG.

Toxicol Appl Pharmacol. 2013 Jun 1;269(2):81-8. doi: 10.1016/j.taap.2013.03.008. Epub 2013 Mar 21.


Poly(ADP-ribose) polymerase-1 inhibition by arsenite promotes the survival of cells with unrepaired DNA lesions induced by UV exposure.

Qin XJ, Liu W, Li YN, Sun X, Hai CX, Hudson LG, Liu KJ.

Toxicol Sci. 2012 May;127(1):120-9. doi: 10.1093/toxsci/kfs099. Epub 2012 Mar 2.


Differential sensitivities of cellular XPA and PARP-1 to arsenite inhibition and zinc rescue.

Ding X, Zhou X, Cooper KL, Huestis J, Hudson LG, Liu KJ.

Toxicol Appl Pharmacol. 2017 Sep 15;331:108-115. doi: 10.1016/j.taap.2017.05.031. Epub 2017 May 25.


Arsenite-induced ROS/RNS generation causes zinc loss and inhibits the activity of poly(ADP-ribose) polymerase-1.

Wang F, Zhou X, Liu W, Sun X, Chen C, Hudson LG, Jian Liu K.

Free Radic Biol Med. 2013 Aug;61:249-56. doi: 10.1016/j.freeradbiomed.2013.04.019. Epub 2013 Apr 18.


Arsenite interacts selectively with zinc finger proteins containing C3H1 or C4 motifs.

Zhou X, Sun X, Cooper KL, Wang F, Liu KJ, Hudson LG.

J Biol Chem. 2011 Jul 1;286(26):22855-63. doi: 10.1074/jbc.M111.232926. Epub 2011 May 5.


Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair.

King BS, Cooper KL, Liu KJ, Hudson LG.

J Biol Chem. 2012 Nov 16;287(47):39824-33. doi: 10.1074/jbc.M112.393504. Epub 2012 Oct 4.


Melanocytes and keratinocytes have distinct and shared responses to ultraviolet radiation and arsenic.

Cooper KL, Yager JW, Hudson LG.

Toxicol Lett. 2014 Jan 30;224(3):407-15. doi: 10.1016/j.toxlet.2013.11.010. Epub 2013 Nov 21.


Poly(ADP-ribosyl)ation of p53 contributes to TPEN-induced neuronal apoptosis.

Kim HL, Ra H, Kim KR, Lee JM, Im H, Kim YH.

Mol Cells. 2015 Apr;38(4):312-7. doi: 10.14348/molcells.2015.2142. Epub 2015 Mar 20.


Inhibition of poly(ADP-ribose)polymerase-1 and DNA repair by uranium.

Cooper KL, Dashner EJ, Tsosie R, Cho YM, Lewis J, Hudson LG.

Toxicol Appl Pharmacol. 2016 Jan 15;291:13-20. doi: 10.1016/j.taap.2015.11.017. Epub 2015 Nov 25.


Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure.

Komissarova EV, Rossman TG.

Toxicol Appl Pharmacol. 2010 Mar 15;243(3):399-404. doi: 10.1016/j.taap.2009.12.014. Epub 2009 Dec 28.


Interdependent genotoxic mechanisms of monomethylarsonous acid: role of ROS-induced DNA damage and poly(ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells.

Wnek SM, Kuhlman CL, Camarillo JM, Medeiros MK, Liu KJ, Lau SS, Gandolfi AJ.

Toxicol Appl Pharmacol. 2011 Nov 15;257(1):1-13. doi: 10.1016/j.taap.2011.08.029. Epub 2011 Sep 10.


Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells.

Walter I, Schwerdtle T, Thuy C, Parsons JL, Dianov GL, Hartwig A.

DNA Repair (Amst). 2007 Jan 4;6(1):61-70. Epub 2006 Sep 29.


Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells.

Xu H, Zhou X, Wen X, Lauer FT, Liu KJ, Hudson LG, Aleksunes LM, Burchiel SW.

Toxicol Sci. 2016 Jan;149(1):31-41. doi: 10.1093/toxsci/kfv211. Epub 2015 Oct 5.


Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair.

Dantzer F, Amé JC, Schreiber V, Nakamura J, Ménissier-de Murcia J, de Murcia G.

Methods Enzymol. 2006;409:493-510.


Lack of poly(ADP-ribose) polymerase-1 gene product enhances cellular sensitivity to arsenite.

Poonepalli A, Balakrishnan L, Khaw AK, Low GK, Jayapal M, Bhattacharjee RN, Akira S, Balajee AS, Hande MP.

Cancer Res. 2005 Dec 1;65(23):10977-83.


DNA excision repair and DNA damage-induced apoptosis are linked to Poly(ADP-ribosyl)ation but have different requirements for p53.

Beneke R, Geisen C, Zevnik B, Bauch T, Müller WU, Küpper JH, Möröy T.

Mol Cell Biol. 2000 Sep;20(18):6695-703.

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