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Items: 1 to 20 of 106

1.

Chimeric RXFP1 and RXFP2 Receptors Highlight the Similar Mechanism of Activation Utilizing Their N-Terminal Low-Density Lipoprotein Class A Modules.

Bruell S, Kong RC, Petrie EJ, Hoare B, Wade JD, Scott DJ, Gooley PR, Bathgate RA.

Front Endocrinol (Lausanne). 2013 Nov 11;4:171. doi: 10.3389/fendo.2013.00171. eCollection 2013.

3.

Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation.

Kong RC, Bathgate RA, Bruell S, Wade JD, Gooley PR, Petrie EJ.

Biochemistry. 2014 Jul 22;53(28):4537-48. doi: 10.1021/bi500797d. Epub 2014 Jul 10.

PMID:
24983702
4.

Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin.

Bruell S, Sethi A, Smith N, Scott DJ, Hossain MA, Wu QP, Guo ZY, Petrie EJ, Gooley PR, Bathgate RAD.

Sci Rep. 2017 Jun 12;7(1):3294. doi: 10.1038/s41598-017-03638-4.

5.

The relaxin receptor (RXFP1) utilizes hydrophobic moieties on a signaling surface of its N-terminal low density lipoprotein class A module to mediate receptor activation.

Kong RC, Petrie EJ, Mohanty B, Ling J, Lee JC, Gooley PR, Bathgate RA.

J Biol Chem. 2013 Sep 27;288(39):28138-51. doi: 10.1074/jbc.M113.499640. Epub 2013 Aug 7.

6.

The different ligand-binding modes of relaxin family peptide receptors RXFP1 and RXFP2.

Scott DJ, Rosengren KJ, Bathgate RA.

Mol Endocrinol. 2012 Nov;26(11):1896-906. doi: 10.1210/me.2012-1188. Epub 2012 Sep 12.

7.

Resolving the unconventional mechanisms underlying RXFP1 and RXFP2 receptor function.

Hartley BJ, Scott DJ, Callander GE, Wilkinson TN, Ganella DE, Kong CK, Layfield S, Ferraro T, Petrie EJ, Bathgate RA.

Ann N Y Acad Sci. 2009 Apr;1160:67-73. doi: 10.1111/j.1749-6632.2009.03949.x.

PMID:
19416161
8.

Investigation of interactions at the extracellular loops of the relaxin family peptide receptor 1 (RXFP1).

Diepenhorst NA, Petrie EJ, Chen CZ, Wang A, Hossain MA, Bathgate RA, Gooley PR.

J Biol Chem. 2014 Dec 12;289(50):34938-52. doi: 10.1074/jbc.M114.600882. Epub 2014 Oct 28.

9.

Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms.

Halls ML, Bathgate RA, Summers RJ.

Mol Pharmacol. 2006 Jul;70(1):214-26. Epub 2006 Mar 28.

10.

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1.

Sethi A, Bruell S, Patil N, Hossain MA, Scott DJ, Petrie EJ, Bathgate RA, Gooley PR.

Nat Commun. 2016 Apr 18;7:11344. doi: 10.1038/ncomms11344.

11.

Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8).

Halls ML, Bond CP, Sudo S, Kumagai J, Ferraro T, Layfield S, Bathgate RA, Summers RJ.

J Pharmacol Exp Ther. 2005 May;313(2):677-87. Epub 2005 Jan 12.

12.

In a Class of Their Own - RXFP1 and RXFP2 are Unique Members of the LGR Family.

Petrie EJ, Lagaida S, Sethi A, Bathgate RA, Gooley PR.

Front Endocrinol (Lausanne). 2015 Sep 7;6:137. doi: 10.3389/fendo.2015.00137. eCollection 2015. Review.

13.

Prolonged RXFP1 and RXFP2 signaling can be explained by poor internalization and a lack of beta-arrestin recruitment.

Callander GE, Thomas WG, Bathgate RA.

Am J Physiol Cell Physiol. 2009 May;296(5):C1058-66. doi: 10.1152/ajpcell.00581.2008. Epub 2009 Mar 11.

14.

Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules.

Scott DJ, Layfield S, Yan Y, Sudo S, Hsueh AJ, Tregear GW, Bathgate RA.

J Biol Chem. 2006 Nov 17;281(46):34942-54. Epub 2006 Sep 8.

15.

Chimeric relaxin peptides highlight the role of the A-chain in the function of H2 relaxin.

Hossain MA, Wade JD, Bathgate RA.

Peptides. 2012 May;35(1):102-6. doi: 10.1016/j.peptides.2012.02.021. Epub 2012 Mar 5.

PMID:
22414484
16.

Relaxin family peptide receptor (RXFP1) coupling to G(alpha)i3 involves the C-terminal Arg752 and localization within membrane Raft Microdomains.

Halls ML, van der Westhuizen ET, Wade JD, Evans BA, Bathgate RA, Summers RJ.

Mol Pharmacol. 2009 Feb;75(2):415-28. doi: 10.1124/mol.108.051227. Epub 2008 Nov 24.

17.

Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes.

Halls ML, Bathgate RA, Summers RJ.

J Pharmacol Exp Ther. 2007 Jan;320(1):281-90. Epub 2006 Oct 25.

18.

The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors.

Hossain MA, Rosengren KJ, Haugaard-J├Ânsson LM, Zhang S, Layfield S, Ferraro T, Daly NL, Tregear GW, Wade JD, Bathgate RA.

J Biol Chem. 2008 Jun 20;283(25):17287-97. doi: 10.1074/jbc.M801911200. Epub 2008 Apr 22.

19.

Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin.

Chan LJ, Rosengren KJ, Layfield SL, Bathgate RA, Separovic F, Samuel CS, Hossain MA, Wade JD.

J Biol Chem. 2012 Nov 30;287(49):41152-64. doi: 10.1074/jbc.M112.409284. Epub 2012 Sep 28.

20.

Membrane receptors: structure and function of the relaxin family peptide receptors.

Kong RC, Shilling PJ, Lobb DK, Gooley PR, Bathgate RA.

Mol Cell Endocrinol. 2010 May 14;320(1-2):1-15. doi: 10.1016/j.mce.2010.02.003. Epub 2010 Feb 6. Review.

PMID:
20138959

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