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Protective effects elicited by levosimendan against liver ischemia/reperfusion injury in anesthetized rats.

Grossini E, Pollesello P, Bellofatto K, Sigaudo L, Farruggio S, Origlia V, Mombello C, Mary DA, Valente G, Vacca G.

Liver Transpl. 2014 Mar;20(3):361-75. doi: 10.1002/lt.23799. Epub 2014 Jan 27.


Levosimendan protection against kidney ischemia/reperfusion injuries in anesthetized pigs.

Grossini E, Molinari C, Pollesello P, Bellomo G, Valente G, Mary D, Vacca G, Caimmi P.

J Pharmacol Exp Ther. 2012 Aug;342(2):376-88. doi: 10.1124/jpet.112.193961. Epub 2012 May 7.


Molecular mechanisms contributing to the protective effect of levosimendan in liver ischemia-reperfusion injury.

Ibrahim MA, Abdel-Gaber SA, Amin EF, Ibrahim SA, Mohammed RK, Abdelrahman AM.

Eur J Pharmacol. 2014 Oct 15;741:64-73. doi: 10.1016/j.ejphar.2014.07.047. Epub 2014 Aug 2.


Levosimendan inhibits peroxidation in hepatocytes by modulating apoptosis/autophagy interplay.

Grossini E, Bellofatto K, Farruggio S, Sigaudo L, Marotta P, Raina G, De Giuli V, Mary D, Pollesello P, Minisini R, Pirisi M, Vacca G.

PLoS One. 2015 Apr 16;10(4):e0124742. doi: 10.1371/journal.pone.0124742. eCollection 2015.


Levosimendan induces NO production through p38 MAPK, ERK and Akt in porcine coronary endothelial cells: role for mitochondrial K(ATP) channel.

Grossini E, Molinari C, Caimmi PP, Uberti F, Vacca G.

Br J Pharmacol. 2009 Jan;156(2):250-61. doi: 10.1111/j.1476-5381.2008.00024.x. Epub 2009 Jan 16.


Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide.

Wang Y, Kudo M, Xu M, Ayub A, Ashraf M.

J Mol Cell Cardiol. 2001 Nov;33(11):2037-46.


Levosimendan modulates programmed forms of cell death through K(ATP) channels and nitric oxide.

Uberti F, Caimmi PP, Molinari C, Mary D, Vacca G, Grossini E.

J Cardiovasc Pharmacol. 2011 Feb;57(2):246-58. doi: 10.1097/FJC.0b013e318204bb55.


Postconditioning with levosimendan reduces the infarct size involving the PI3K pathway and KATP-channel activation but is independent of PDE-III inhibition.

Hönisch A, Theuring N, Ebner B, Wagner C, Strasser RH, Weinbrenner C.

Basic Res Cardiol. 2010 Mar;105(2):155-67. doi: 10.1007/s00395-009-0064-9. Epub 2009 Oct 16.


Influence of levosimendan postconditioning on apoptosis of rat lung cells in a model of ischemia-reperfusion injury.

Zhang C, Guo Z, Liu H, Shi Y, Ge S.

PLoS One. 2015 Jan 21;10(1):e0114963. doi: 10.1371/journal.pone.0114963. eCollection 2015.


Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: the role of endothelial nitric oxide synthase.

Lv L, Jiang SS, Xu J, Gong JB, Cheng Y.

Clin Exp Pharmacol Physiol. 2012 Jan;39(1):20-7. doi: 10.1111/j.1440-1681.2011.05628.x.


Nicorandil inhibits hypoxia-induced apoptosis in human pulmonary artery endothelial cells through activation of mitoKATP and regulation of eNOS and the NF-κB pathway.

Wang H, Zuo X, Wang Q, Yu Y, Xie L, Wang H, Wu H, Xie W.

Int J Mol Med. 2013 Jul;32(1):187-94. doi: 10.3892/ijmm.2013.1379. Epub 2013 May 13.


Contribution of Akt and endothelial nitric oxide synthase to diazoxide-induced late preconditioning.

Wang Y, Ahmad N, Kudo M, Ashraf M.

Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1125-31. Epub 2004 May 13.


Delayed preconditioning prevents ischemia/reperfusion-induced endothelial injury in rats: role of ROS and eNOS.

He X, Zhao M, Bi XY, Yu XJ, Zang WJ.

Lab Invest. 2013 Feb;93(2):168-80. doi: 10.1038/labinvest.2012.160. Epub 2012 Nov 12.


Pharmacological preconditioning using intraportal infusion of L-arginine protects against hepatic ischemia reperfusion injury.

Giovanardi RO, Rhoden EL, Cerski CT, Salvador M, Kalil AN.

J Surg Res. 2009 Aug;155(2):244-53. doi: 10.1016/j.jss.2008.07.002. Epub 2008 Aug 24.


Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats.

Okajima K, Harada N, Uchiba M, Mori M.

Am J Physiol Gastrointest Liver Physiol. 2004 Dec;287(6):G1116-23. Epub 2004 Jul 8.


Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction.

Yasuda S, Kobayashi H, Iwasa M, Kawamura I, Sumi S, Narentuoya B, Yamaki T, Ushikoshi H, Nishigaki K, Nagashima K, Takemura G, Fujiwara T, Fujiwara H, Minatoguchi S.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1558-65. doi: 10.1152/ajpheart.00712.2008. Epub 2009 Mar 13.


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