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Items: 1 to 20 of 91

1.

A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.

Siggs OM, Yates AL, Schlenner S, Liston A, Lesage S, Goodnow CC.

Immunology. 2014 Apr;141(4):587-95. doi: 10.1111/imm.12220.

2.

Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selection.

Haks MC, Pépin E, van den Brakel JH, Smeele SA, Belkowski SM, Kessels HW, Krimpenfort P, Kruisbeek AM.

J Exp Med. 2002 Jul 1;196(1):1-13.

3.

A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling.

Cauwe B, Tian L, Franckaert D, Pierson W, Staats KA, Schlenner SM, Liston A.

Immunology. 2014 Mar;141(3):377-87. doi: 10.1111/imm.12199.

4.

Regulation of Zap70 expression during thymocyte development enables temporal separation of CD4 and CD8 repertoire selection at different signaling thresholds.

Saini M, Sinclair C, Marshall D, Tolaini M, Sakaguchi S, Seddon B.

Sci Signal. 2010 Mar 23;3(114):ra23. doi: 10.1126/scisignal.2000702.

5.

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development.

Wiest DL, Ashe JM, Howcroft TK, Lee HM, Kemper DM, Negishi I, Singer DS, Singer A, Abe R.

Immunity. 1997 Jun;6(6):663-71.

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CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity.

Azzam HS, Grinberg A, Lui K, Shen H, Shores EW, Love PE.

J Exp Med. 1998 Dec 21;188(12):2301-11.

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A Zap70-dependent feedback circuit is essential for efficient selection of CD4 lineage thymocytes.

Sinclair C, Ono M, Seddon B.

Immunol Cell Biol. 2015 Apr;93(4):406-16. doi: 10.1038/icb.2014.107. Epub 2015 Jan 20.

PMID:
25601273
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13.

Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules.

Yamasaki S, Nishida K, Hibi M, Sakuma M, Shiina R, Takeuchi A, Ohnishi H, Hirano T, Saito T.

J Biol Chem. 2001 Nov 30;276(48):45175-83. Epub 2001 Sep 25.

14.

CD69 expression during selection and maturation of CD4+8+ thymocytes.

Swat W, Dessing M, von Boehmer H, Kisielow P.

Eur J Immunol. 1993 Mar;23(3):739-46.

PMID:
8095460
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The fas antigen is involved in thymic T-cell development as a costimulatory molecule, but not in the deletion of neglected thymocytes.

Kurasawa K, Hashimoto Y, Kasai M, Iwamoto I.

J Allergy Clin Immunol. 2000 Jul;106(1 Pt 2):S19-31.

PMID:
10887330
17.

A role for CD5 in TCR-mediated signal transduction and thymocyte selection.

Tarakhovsky A, Kanner SB, Hombach J, Ledbetter JA, Müller W, Killeen N, Rajewsky K.

Science. 1995 Jul 28;269(5223):535-7.

PMID:
7542801
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19.

Essential role for ZAP-70 in both positive and negative selection of thymocytes.

Negishi I, Motoyama N, Nakayama K, Nakayama K, Senju S, Hatakeyama S, Zhang Q, Chan AC, Loh DY.

Nature. 1995 Aug 3;376(6539):435-8.

PMID:
7630421
20.

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.

Thien CB, Blystad FD, Zhan Y, Lew AM, Voigt V, Andoniou CE, Langdon WY.

EMBO J. 2005 Nov 2;24(21):3807-19. Epub 2005 Oct 6.

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