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Items: 1 to 20 of 68

1.

Chronic mTOR activation promotes cell survival in Merkel cell carcinoma.

Lin Z, McDermott A, Shao L, Kannan A, Morgan M, Stack BC Jr, Moreno M, Davis DA, Cornelius LA, Gao L.

Cancer Lett. 2014 Mar 28;344(2):272-81. doi: 10.1016/j.canlet.2013.11.005. Epub 2013 Nov 19.

2.

Dual mTOR inhibitor MLN0128 suppresses Merkel cell carcinoma (MCC) xenograft tumor growth.

Kannan A, Lin Z, Shao Q, Zhao S, Fang B, Moreno MA, Vural E, Stack BC Jr, Suen JY, Kannan K, Gao L.

Oncotarget. 2016 Feb 9;7(6):6576-92. doi: 10.18632/oncotarget.5878.

3.

Comparison of Akt/mTOR/4E-BP1 pathway signal activation and mutations of PIK3CA in Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative carcinomas.

Iwasaki T, Matsushita M, Nonaka D, Kuwamoto S, Kato M, Murakami I, Nagata K, Nakajima H, Sano S, Hayashi K.

Hum Pathol. 2015 Feb;46(2):210-6. doi: 10.1016/j.humpath.2014.07.025. Epub 2014 Oct 23.

PMID:
25466966
4.

Role of autophagy in apoptotic regulation by Akt in pancreatic cancer.

Muilenburg D, Parsons C, Coates J, Virudachalam S, Bold RJ.

Anticancer Res. 2014 Feb;34(2):631-7.

5.

mTOR inhibitor RAD001 (everolimus) induces apoptotic, not autophagic cell death, in human nasopharyngeal carcinoma cells.

Cai Y, Xia Q, Su Q, Luo R, Sun Y, Shi Y, Jiang W.

Int J Mol Med. 2013 Apr;31(4):904-12. doi: 10.3892/ijmm.2013.1282. Epub 2013 Feb 21.

PMID:
23426850
6.

Activation of the PI3K/AKT pathway in Merkel cell carcinoma.

Hafner C, Houben R, Baeurle A, Ritter C, Schrama D, Landthaler M, Becker JC.

PLoS One. 2012;7(2):e31255. doi: 10.1371/journal.pone.0031255. Epub 2012 Feb 17.

7.

Activation of the MAP kinase pathway induces apoptosis in the Merkel cell carcinoma cell line UISO.

Houben R, Ortmann S, Schrama D, Herold MJ, Berberich I, Reichardt HM, Becker JC.

J Invest Dermatol. 2007 Sep;127(9):2116-22. Epub 2007 May 3.

8.

Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.

Vucicevic L, Misirkic M, Janjetovic K, Vilimanovich U, Sudar E, Isenovic E, Prica M, Harhaji-Trajkovic L, Kravic-Stevovic T, Bumbasirevic V, Trajkovic V.

Autophagy. 2011 Jan;7(1):40-50. Epub 2011 Jan 1.

PMID:
20980833
9.

Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma.

Müller A, Zang C, Chumduri C, Dörken B, Daniel PT, Scholz CW.

Int J Cancer. 2013 Oct 15;133(8):1813-24. doi: 10.1002/ijc.28206. Epub 2013 Jun 15.

10.

Activation of PI3K signaling in Merkel cell carcinoma.

Nardi V, Song Y, Santamaria-Barria JA, Cosper AK, Lam Q, Faber AC, Boland GM, Yeap BY, Bergethon K, Scialabba VL, Tsao H, Settleman J, Ryan DP, Borger DR, Bhan AK, Hoang MP, Iafrate AJ, Cusack JC, Engelman JA, Dias-Santagata D.

Clin Cancer Res. 2012 Mar 1;18(5):1227-36. doi: 10.1158/1078-0432.CCR-11-2308. Epub 2012 Jan 18.

11.

IPF fibroblasts are desensitized to type I collagen matrix-induced cell death by suppressing low autophagy via aberrant Akt/mTOR kinases.

Nho RS, Hergert P.

PLoS One. 2014 Apr 11;9(4):e94616. doi: 10.1371/journal.pone.0094616. eCollection 2014.

12.

PDK1 is a potential therapeutic target against angiosarcoma cells.

Wada M, Horinaka M, Yasuda S, Masuzawa M, Sakai T, Katoh N.

J Dermatol Sci. 2015 Apr;78(1):44-50. doi: 10.1016/j.jdermsci.2015.01.015. Epub 2015 Feb 7.

PMID:
25726712
13.

Detection of Merkel cell polyomavirus in formalin-fixed, paraffin-embedded tissue of Merkel cell carcinoma and correlation with prognosis.

Andea AA, Patel R, Ponnazhagan S, Isayeva T, Kumar S, Siegal GP.

Rom J Morphol Embryol. 2014;55(3 Suppl):1057-62.

14.

Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro.

Liu H, Scholz C, Zang C, Schefe JH, Habbel P, Regierer AC, Schulz CO, Possinger K, Eucker J.

Anticancer Res. 2012 May;32(5):1627-37.

PMID:
22593441
15.

SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells.

Pasquier B.

Autophagy. 2015 Apr 3;11(4):725-6. doi: 10.1080/15548627.2015.1033601.

16.

Cyclooxygenase-2 expression in primary and metastatic Merkel cell carcinoma.

Joachims Z, Feinmesser R, Purim O, Halpern M, Brenner B, Fenig E, Roizman P, Sulkes J, Feinmesser M.

Appl Immunohistochem Mol Morphol. 2008 Oct;16(5):442-6. doi: 10.1097/PAI.0b013e31815f982a.

PMID:
18594470
17.

Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells.

Li H, Jin X, Zhang Z, Xing Y, Kong X.

Cell Biochem Funct. 2013 Jul;31(5):427-33. doi: 10.1002/cbf.2917. Epub 2012 Oct 22.

PMID:
23086777
18.

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy.

Shi WY, Xiao D, Wang L, Dong LH, Yan ZX, Shen ZX, Chen SJ, Chen Y, Zhao WL.

Cell Death Dis. 2012 Mar 1;3:e275. doi: 10.1038/cddis.2012.13.

19.

Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator.

Shuda M, Kwun HJ, Feng H, Chang Y, Moore PS.

J Clin Invest. 2011 Sep;121(9):3623-34. doi: 10.1172/JCI46323. Epub 2011 Aug 15.

20.

Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition.

Bray K, Mathew R, Lau A, Kamphorst JJ, Fan J, Chen J, Chen HY, Ghavami A, Stein M, DiPaola RS, Zhang D, Rabinowitz JD, White E.

PLoS One. 2012;7(7):e41831. doi: 10.1371/journal.pone.0041831. Epub 2012 Jul 26.

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