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Items: 1 to 20 of 97

1.

Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity.

Rai G, Kawamura A, Tumber A, Liang Y, Vogel JL, Arbuckle JH, Rose NR, Dexheimer TS, Foley TL, King ON, Quinn A, Mott BT, Schofield CJ, Oppermann U, Jadhav A, Simeonov A, Kristie TM, Maloney DJ.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Dec 17 [updated 2013 Sep 16].

2.

A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency.

Liang Y, Quenelle D, Vogel JL, Mascaro C, Ortega A, Kristie TM.

MBio. 2013 Feb 5;4(1):e00558-12. doi: 10.1128/mBio.00558-12.

3.

Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency.

Liang Y, Vogel JL, Arbuckle JH, Rai G, Jadhav A, Simeonov A, Maloney DJ, Kristie TM.

Sci Transl Med. 2013 Jan 9;5(167):167ra5. doi: 10.1126/scitranslmed.3005145.

4.

Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.

Hill JM, Quenelle DC, Cardin RD, Vogel JL, Clement C, Bravo FJ, Foster TP, Bosch-Marce M, Raja P, Lee JS, Bernstein DI, Krause PR, Knipe DM, Kristie TM.

Sci Transl Med. 2014 Dec 3;6(265):265ra169. doi: 10.1126/scitranslmed.3010643.

5.

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, Schofield CJ, Simeonov A.

PLoS One. 2010 Nov 23;5(11):e15535. doi: 10.1371/journal.pone.0015535.

6.

Histone Lysine Demethylases of JMJD2 or KDM4 Family are Important Epigenetic Regulators in Reward Circuitry in the Etiopathology of Depression.

Pathak SS, Maitra S, Chakravarty S, Kumar A.

Neuropsychopharmacology. 2017 Mar;42(4):854-863. doi: 10.1038/npp.2016.231. Epub 2016 Oct 6.

PMID:
27711046
7.

Epigenetically repressing human cytomegalovirus lytic infection and reactivation from latency in THP-1 model by targeting H3K9 and H3K27 histone demethylases.

Gan X, Wang H, Yu Y, Yi W, Zhu S, Li E, Liang Y.

PLoS One. 2017 Apr 13;12(4):e0175390. doi: 10.1371/journal.pone.0175390. eCollection 2017.

8.

Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency.

Liang Y, Vogel JL, Narayanan A, Peng H, Kristie TM.

Nat Med. 2009 Nov;15(11):1312-7. doi: 10.1038/nm.2051. Epub 2009 Oct 25.

9.

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.

Hamada S, Suzuki T, Mino K, Koseki K, Oehme F, Flamme I, Ozasa H, Itoh Y, Ogasawara D, Komaarashi H, Kato A, Tsumoto H, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Miyata N.

J Med Chem. 2010 Aug 12;53(15):5629-38. doi: 10.1021/jm1003655.

PMID:
20684604
10.

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

Bavetsias V, Lanigan RM, Ruda GF, Atrash B, McLaughlin MG, Tumber A, Mok NY, Le Bihan YV, Dempster S, Boxall KJ, Jeganathan F, Hatch SB, Savitsky P, Velupillai S, Krojer T, England KS, Sejberg J, Thai C, Donovan A, Pal A, Scozzafava G, Bennett JM, Kawamura A, Johansson C, Szykowska A, Gileadi C, Burgess-Brown NA, von Delft F, Oppermann U, Walters Z, Shipley J, Raynaud FI, Westaway SM, Prinjha RK, Fedorov O, Burke R, Schofield CJ, Westwood IM, Bountra C, Müller S, van Montfort RL, Brennan PE, Blagg J.

J Med Chem. 2016 Feb 25;59(4):1388-409. doi: 10.1021/acs.jmedchem.5b01635. Epub 2016 Jan 7.

11.

Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens.

Arbuckle JH, Gardina PJ, Gordon DN, Hickman HD, Yewdell JW, Pierson TC, Myers TG, Kristie TM.

MBio. 2017 Aug 15;8(4). pii: e01141-17. doi: 10.1128/mBio.01141-17.

12.

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

Horton JR, Engstrom A, Zoeller EL, Liu X, Shanks JR, Zhang X, Johns MA, Vertino PM, Fu H, Cheng X.

J Biol Chem. 2016 Feb 5;291(6):2631-46. doi: 10.1074/jbc.M115.698449. Epub 2015 Dec 8.

13.

The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.

Murray-Stewart T, Woster PM, Casero RA Jr.

Amino Acids. 2014 Mar;46(3):585-94. doi: 10.1007/s00726-013-1485-1. Epub 2013 Mar 19.

14.

Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C).

Leurs U, Clausen RP, Kristensen JL, Lohse B.

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5811-3. doi: 10.1016/j.bmcl.2012.07.091. Epub 2012 Aug 2.

PMID:
22917519
15.

Diversity within the JMJD2 histone demethylase family.

Shin S, Janknecht R.

Biochem Biophys Res Commun. 2007 Feb 23;353(4):973-7. Epub 2006 Dec 27.

PMID:
17207460
16.

KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells.

Berry WL, Janknecht R.

Cancer Res. 2013 May 15;73(10):2936-42. doi: 10.1158/0008-5472.CAN-12-4300. Epub 2013 May 3. Review.

17.

Development of homogeneous nonradioactive methyltransferase and demethylase assays targeting histone H3 lysine 4.

Gauthier N, Caron M, Pedro L, Arcand M, Blouin J, Labonté A, Normand C, Paquet V, Rodenbrock A, Roy M, Rouleau N, Beaudet L, Padrós J, Rodriguez-Suarez R.

J Biomol Screen. 2012 Jan;17(1):49-58. doi: 10.1177/1087057111416659. Epub 2011 Sep 21.

PMID:
21940714
18.

Inhibition of H3K27me3-specific histone demethylases JMJD3 and UTX blocks reactivation of herpes simplex virus 1 in trigeminal ganglion neurons.

Messer HG, Jacobs D, Dhummakupt A, Bloom DC.

J Virol. 2015 Mar;89(6):3417-20. doi: 10.1128/JVI.03052-14. Epub 2014 Dec 31.

19.

Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy.

Giri NC, Passantino L, Sun H, Zoroddu MA, Costa M, Maroney MJ.

Biochemistry. 2013 Jun 18;52(24):4168-83. doi: 10.1021/bi400274v. Epub 2013 Jun 7.

20.

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

Thalhammer A, Mecinović J, Loenarz C, Tumber A, Rose NR, Heightman TD, Schofield CJ.

Org Biomol Chem. 2011 Jan 7;9(1):127-35. doi: 10.1039/c0ob00592d. Epub 2010 Nov 15.

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