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Items: 1 to 20 of 174

1.

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models.

Schleiferböck S, Scheurer C, Ihara M, Itoh I, Bathurst I, Burrows JN, Fantauzzi P, Lotharius J, Charman SA, Morizzi J, Shackleford DM, White KL, Brun R, Wittlin S.

Drug Des Devel Ther. 2013 Nov 15;7:1377-84. doi: 10.2147/DDDT.S51298. eCollection 2013.

2.

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.

Le Bihan A, de Kanter R, Angulo-Barturen I, Binkert C, Boss C, Brun R, Brunner R, Buchmann S, Burrows J, Dechering KJ, Delves M, Ewerling S, Ferrer S, Fischli C, Gamo-Benito FJ, Gnädig NF, Heidmann B, Jiménez-Díaz MB, Leroy D, Martínez MS, Meyer S, Moehrle JJ, Ng CL, Noviyanti R, Ruecker A, Sanz LM, Sauerwein RW, Scheurer C, Schleiferboeck S, Sinden R, Snyder C, Straimer J, Wirjanata G, Marfurt J, Price RN, Weller T, Fischli W, Fidock DA, Clozel M, Wittlin S.

PLoS Med. 2016 Oct 4;13(10):e1002138. doi: 10.1371/journal.pmed.1002138. eCollection 2016 Oct.

3.

Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites.

Mizukawa Y, Ge JF, Bakar Md A, Itoh I, Scheurer C, Wittlin S, Brun R, Matsuoka H, Ihara M.

Bioorg Med Chem. 2014 Jul 15;22(14):3749-52. doi: 10.1016/j.bmc.2014.04.066. Epub 2014 May 10.

PMID:
24856305
4.

A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.

Le Manach C, Paquet T, Brunschwig C, Njoroge M, Han Z, Gonzàlez Cabrera D, Bashyam S, Dhinakaran R, Taylor D, Reader J, Botha M, Churchyard A, Lauterbach S, Coetzer TL, Birkholtz LM, Meister S, Winzeler EA, Waterson D, Witty MJ, Wittlin S, Jiménez-Díaz MB, Santos Martínez M, Ferrer S, Angulo-Barturen I, Street LJ, Chibale K.

J Med Chem. 2015 Nov 12;58(21):8713-22. doi: 10.1021/acs.jmedchem.5b01605. Epub 2015 Nov 2.

PMID:
26502160
5.

Protective activity of biflavanones from Garcinia kola against Plasmodium infection.

Konziase B.

J Ethnopharmacol. 2015 Aug 22;172:214-8. doi: 10.1016/j.jep.2015.06.038. Epub 2015 Jun 27.

PMID:
26129936
6.

Pharmacodynamics and pharmacokinetics studies of phenoxazinium derivatives for antimalarial agent.

Yang M, Ge JF, Arai C, Itoh I, Fu Q, Ihara M.

Bioorg Med Chem. 2009 Feb 15;17(4):1481-5. doi: 10.1016/j.bmc.2009.01.021. Epub 2009 Jan 15.

PMID:
19181530
7.

New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.

Soares RR, da Silva JM, Carlos BC, da Fonseca CC, de Souza LS, Lopes FV, de Paula Dias RM, Moreira PO, Abramo C, Viana GH, de Pila Varotti F, da Silva AD, Scopel KK.

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2308-13. doi: 10.1016/j.bmcl.2015.04.014. Epub 2015 Apr 11.

PMID:
25920564
8.

3,5-bis(benzylidene)-4-piperidones and related N-acyl analogs: a novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum.

Das U, Singh RS, Alcorn J, Hickman MR, Sciotti RJ, Leed SE, Lee PJ, Roncal N, Dimmock JR.

Bioorg Med Chem. 2013 Dec 1;21(23):7250-6. doi: 10.1016/j.bmc.2013.09.065. Epub 2013 Oct 8.

PMID:
24139941
9.

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.

Biagini GA, Fisher N, Shone AE, Mubaraki MA, Srivastava A, Hill A, Antoine T, Warman AJ, Davies J, Pidathala C, Amewu RK, Leung SC, Sharma R, Gibbons P, Hong DW, Pacorel B, Lawrenson AS, Charoensutthivarakul S, Taylor L, Berger O, Mbekeani A, Stocks PA, Nixon GL, Chadwick J, Hemingway J, Delves MJ, Sinden RE, Zeeman AM, Kocken CH, Berry NG, O'Neill PM, Ward SA.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8298-303. doi: 10.1073/pnas.1205651109. Epub 2012 May 7.

10.

Synthesis, antimalarial activity, and intracellular targets of MEFAS, a new hybrid compound derived from mefloquine and artesunate.

de Pilla Varotti F, Botelho AC, Andrade AA, de Paula RC, Fagundes EM, Valverde A, Mayer LM, Mendonça JS, de Souza MV, Boechat N, Krettli AU.

Antimicrob Agents Chemother. 2008 Nov;52(11):3868-74. doi: 10.1128/AAC.00510-08. Epub 2008 Aug 18.

11.

Stearylamine Liposomal Delivery of Monensin in Combination with Free Artemisinin Eliminates Blood Stages of Plasmodium falciparum in Culture and P. berghei Infection in Murine Malaria.

Rajendran V, Rohra S, Raza M, Hasan GM, Dutt S, Ghosh PC.

Antimicrob Agents Chemother. 2015 Dec 14;60(3):1304-18. doi: 10.1128/AAC.01796-15.

12.

Evaluation of the antimalarial activity of new compounds against Plasmodium falciparum in vitro, and Plasmodium berghei in vivo.

Tedlaouti F, Gasquet M, Delmas F, Timon-David P, Madadi NE, Vanelle P, Maldonado J.

J Pharm Belg. 1990 Sep-Oct;45(5):306-10.

PMID:
2086754
13.

Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo.

Khoury DS, Cromer D, Elliott T, Soon MSF, Thomas BS, James KR, Best SE, Aogo RA, Engel JA, Gartlan KH, Akter J, Sebina I, Haque A, Davenport MP.

Int J Parasitol. 2017 Dec;47(14):913-922. doi: 10.1016/j.ijpara.2017.05.009. Epub 2017 Aug 31.

PMID:
28864033
14.

Selective accumulation of a novel antimalarial rhodacyanine derivative, SSJ-127, in an organelle of Plasmodium berghei.

Ikegami-Kawai M, Arai C, Ogawa Y, Yanoshita R, Ihara M.

Bioorg Med Chem. 2010 Nov 15;18(22):7804-8. doi: 10.1016/j.bmc.2010.09.054. Epub 2010 Sep 26.

PMID:
20970347
15.

Identification of a new chemical class of antimalarials.

Brunner R, Aissaoui H, Boss C, Bozdech Z, Brun R, Corminboeuf O, Delahaye S, Fischli C, Heidmann B, Kaiser M, Kamber J, Meyer S, Papastogiannidis P, Siegrist R, Voss T, Welford R, Wittlin S, Binkert C.

J Infect Dis. 2012 Sep 1;206(5):735-43. doi: 10.1093/infdis/jis418. Epub 2012 Jun 25.

PMID:
22732921
16.

JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium.

Birrell GW, Chavchich M, Ager AL, Shieh HM, Heffernan GD, Zhao W, Krasucki PE, Saionz KW, Terpinski J, Schiehser GA, Jacobus LR, Shanks GD, Jacobus DP, Edstein MD.

Antimicrob Agents Chemother. 2015 Jan;59(1):170-7. doi: 10.1128/AAC.03762-14. Epub 2014 Oct 20.

17.
18.

Fluoroartemisinins: metabolically more stable antimalarial artemisinin derivatives.

Bégué JP, Bonnet-Delpon D.

ChemMedChem. 2007 May;2(5):608-24. Review.

PMID:
17252616
19.

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials.

Norcross NR, Baragaña B, Wilson C, Hallyburton I, Osuna-Cabello M, Norval S, Riley J, Stojanovski L, Simeons FR, Porzelle A, Grimaldi R, Wittlin S, Duffy S, Avery VM, Meister S, Sanz L, Jiménez-Díaz B, Angulo-Barturen I, Ferrer S, Martínez MS, Gamo FJ, Frearson JA, Gray DW, Fairlamb AH, Winzeler EA, Waterson D, Campbell SF, Willis P, Read KD, Gilbert IH.

J Med Chem. 2016 Jul 14;59(13):6101-20. doi: 10.1021/acs.jmedchem.6b00028. Epub 2016 Jun 17.

20.

Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum.

Malmquist NA, Moss TA, Mecheri S, Scherf A, Fuchter MJ.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16708-13. doi: 10.1073/pnas.1205414109. Epub 2012 Sep 24.

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