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Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.

Puccini J, Shalini S, Voss AK, Gatei M, Wilson CH, Hiwase DK, Lavin MF, Dorstyn L, Kumar S.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19920-5. doi: 10.1073/pnas.1311947110. Epub 2013 Nov 18.


Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.

Dorstyn L, Puccini J, Wilson CH, Shalini S, Nicola M, Moore S, Kumar S.

Cell Death Differ. 2012 Aug;19(8):1288-98. doi: 10.1038/cdd.2012.36. Epub 2012 Apr 13. Erratum in: Cell Death Differ. 2012 Aug;19(8):1411.


Caspase-2 protects against oxidative stress in vivo.

Shalini S, Puccini J, Wilson CH, Finnie J, Dorstyn L, Kumar S.

Oncogene. 2015 Sep 17;34(38):4995-5002. doi: 10.1038/onc.2014.413. Epub 2014 Dec 22.


ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis.

Vaites LP, Lian Z, Lee EK, Yin B, DeMicco A, Bassing CH, Diehl JA.

Oncogene. 2014 Jan 2;33(1):129-33. doi: 10.1038/onc.2012.577. Epub 2013 Jan 14.


An unexpected role for caspase-2 in neuroblastoma.

Dorstyn L, Puccini J, Nikolic A, Shalini S, Wilson CH, Norris MD, Haber M, Kumar S.

Cell Death Dis. 2014 Aug 21;5:e1383. doi: 10.1038/cddis.2014.342.


Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice.

Shalini S, Dorstyn L, Wilson C, Puccini J, Ho L, Kumar S.

Cell Death Differ. 2012 Aug;19(8):1370-80. doi: 10.1038/cdd.2012.13. Epub 2012 Feb 17.


Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice.

Parsons MJ, McCormick L, Janke L, Howard A, Bouchier-Hayes L, Green DR.

Cell Death Differ. 2013 Sep;20(9):1174-82. doi: 10.1038/cdd.2013.38. Epub 2013 May 3.


Caspase-2-mediated cell death is required for deleting aneuploid cells.

Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar S.

Oncogene. 2017 May 11;36(19):2704-2714. doi: 10.1038/onc.2016.423. Epub 2016 Dec 19.


Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells.

Kinoshita T, Nagamatsu G, Kosaka T, Takubo K, Hotta A, Ellis J, Suda T.

Biochem Biophys Res Commun. 2011 Apr 8;407(2):321-6. doi: 10.1016/j.bbrc.2011.03.013. Epub 2011 Mar 6.


ATM localization and gene expression in the adult mouse eye.

Leemput J, Masson C, Bigot K, Errachid A, Dansault A, Provost A, Gadin S, Aoufouchi S, Menasche M, Abitbol M.

Mol Vis. 2009;15:393-416. Epub 2009 Feb 20.


Control of Atm-/- thymic lymphoma cell proliferation in vitro and in vivo by dexamethasone.

Kuang X, Yan M, Liu N, Scofield VL, Qiang W, Cahill J, Lynn WS, Wong PK.

Cancer Chemother Pharmacol. 2005 Mar;55(3):203-12. Epub 2004 Nov 27.


Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice.

Chen Y, Yang R, Guo P, Ju Z.

Protein Cell. 2014 Jan;5(1):80-9. doi: 10.1007/s13238-013-0017-9. Epub 2014 Jan 29.


Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.

Xu Y, Ashley T, Brainerd EE, Bronson RT, Meyn MS, Baltimore D.

Genes Dev. 1996 Oct 1;10(19):2411-22.


A tumor suppressor function for caspase-2.

Ho LH, Taylor R, Dorstyn L, Cakouros D, Bouillet P, Kumar S.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5336-41. doi: 10.1073/pnas.0811928106. Epub 2009 Mar 11.


The glucocorticoid receptor is increased in Atm-/- thymocytes and in Atm-/- thymic lymphoma cells, and its nuclear translocation counteracts c-myc expression.

Yan M, Kuang X, Scofield VL, Shen J, Lynn WS, Wong PK.

Steroids. 2007 May;72(5):415-21. Epub 2007 Mar 12.


ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

Pusapati RV, Rounbehler RJ, Hong S, Powers JT, Yan M, Kiguchi K, McArthur MJ, Wong PK, Johnson DG.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1446-51. Epub 2006 Jan 23.


Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence.

Zhan H, Suzuki T, Aizawa K, Miyagawa K, Nagai R.

J Biol Chem. 2010 Sep 17;285(38):29662-70. doi: 10.1074/jbc.M110.125138. Epub 2010 Jul 16.

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