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Items: 1 to 20 of 144

1.

Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box.

Bowman JD, Merino EF, Brooks CF, Striepen B, Carlier PR, Cassera MB.

Antimicrob Agents Chemother. 2014;58(2):811-9. doi: 10.1128/AAC.01500-13. Epub 2013 Nov 18.

2.

Identification of MMV malaria box inhibitors of plasmodium falciparum early-stage gametocytes using a luciferase-based high-throughput assay.

Lucantoni L, Duffy S, Adjalley SH, Fidock DA, Avery VM.

Antimicrob Agents Chemother. 2013 Dec;57(12):6050-62. doi: 10.1128/AAC.00870-13. Epub 2013 Sep 23.

3.

Isoprenoid precursor biosynthesis is the essential metabolic role of the apicoplast during gametocytogenesis in Plasmodium falciparum.

Wiley JD, Merino EF, Krai PM, McLean KJ, Tripathi AK, Vega-Rodríguez J, Jacobs-Lorena M, Klemba M, Cassera MB.

Eukaryot Cell. 2015 Feb;14(2):128-39. doi: 10.1128/EC.00198-14. Epub 2014 Dec 1.

4.

A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis.

Wu W, Herrera Z, Ebert D, Baska K, Cho SH, DeRisi JL, Yeh E.

Antimicrob Agents Chemother. 2015 Jan;59(1):356-64. doi: 10.1128/AAC.03342-14. Epub 2014 Nov 3.

5.

Luciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes.

Lucantoni L, Fidock DA, Avery VM.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2097-107. doi: 10.1128/AAC.01949-15. Print 2016 Apr.

6.

Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum.

Yeh E, DeRisi JL.

PLoS Biol. 2011 Aug;9(8):e1001138. doi: 10.1371/journal.pbio.1001138. Epub 2011 Aug 30.

7.

A male and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs.

Ruecker A, Mathias DK, Straschil U, Churcher TS, Dinglasan RR, Leroy D, Sinden RE, Delves MJ.

Antimicrob Agents Chemother. 2014 Dec;58(12):7292-302. doi: 10.1128/AAC.03666-14. Epub 2014 Sep 29.

8.

Progressing the global antimalarial portfolio: finding drugs which target multiple Plasmodium life stages.

Smith PW, Diagana TT, Yeung BK.

Parasitology. 2014 Jan;141(1):66-76. doi: 10.1017/S0031182013000747. Epub 2013 Jun 10. Review.

PMID:
23746048
9.

Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies.

Yao ZK, Krai PM, Merino EF, Simpson ME, Slebodnick C, Cassera MB, Carlier PR.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1515-9. doi: 10.1016/j.bmcl.2015.02.020. Epub 2015 Feb 21.

10.

A New Set of Chemical Starting Points with Plasmodium falciparum Transmission-Blocking Potential for Antimalarial Drug Discovery.

Almela MJ, Lozano S, Lelièvre J, Colmenarejo G, Coterón JM, Rodrigues J, Gonzalez C, Herreros E.

PLoS One. 2015 Aug 28;10(8):e0135139. doi: 10.1371/journal.pone.0135139. eCollection 2015.

11.

The multifunctional autophagy pathway in the human malaria parasite, Plasmodium falciparum.

Cervantes S, Bunnik EM, Saraf A, Conner CM, Escalante A, Sardiu ME, Ponts N, Prudhomme J, Florens L, Le Roch KG.

Autophagy. 2014 Jan;10(1):80-92. doi: 10.4161/auto.26743. Epub 2013 Nov 11.

12.

A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.

Eastman RT, Pattaradilokrat S, Raj DK, Dixit S, Deng B, Miura K, Yuan J, Tanaka TQ, Johnson RL, Jiang H, Huang R, Williamson KC, Lambert LE, Long C, Austin CP, Wu Y, Su XZ.

Antimicrob Agents Chemother. 2013 Jan;57(1):425-35. doi: 10.1128/AAC.00920-12. Epub 2012 Nov 5.

13.

Effect of fluorescent dyes on in vitro-differentiated, late-stage Plasmodium falciparum gametocytes.

Gebru T, Mordmüller B, Held J.

Antimicrob Agents Chemother. 2014 Dec;58(12):7398-404. doi: 10.1128/AAC.03772-14. Epub 2014 Sep 29.

14.

Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening.

Sun W, Huang X, Li H, Tawa G, Fisher E, Tanaka TQ, Shinn P, Huang W, Williamson KC, Zheng W.

Malar J. 2017 Apr 13;16(1):147. doi: 10.1186/s12936-017-1805-0.

15.

Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages.

Roberts BF, Iyamu ID, Lee S, Lee E, Ayong L, Kyle DE, Yuan Y, Manetsch R, Chakrabarti D.

Int J Parasitol Drugs Drug Resist. 2016 Feb 12;6(1):85-92. doi: 10.1016/j.ijpddr.2016.02.004. eCollection 2016 Apr.

16.

Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen.

Tanaka TQ, Guiguemde WA, Barnett DS, Maron MI, Min J, Connelly MC, Suryadevara PK, Guy RK, Williamson KC.

Antimicrob Agents Chemother. 2015 Mar;59(3):1389-97. doi: 10.1128/AAC.01930-13. Epub 2014 Dec 15.

17.

Chemical signatures and new drug targets for gametocytocidal drug development.

Sun W, Tanaka TQ, Magle CT, Huang W, Southall N, Huang R, Dehdashti SJ, McKew JC, Williamson KC, Zheng W.

Sci Rep. 2014 Jan 17;4:3743. doi: 10.1038/srep03743.

18.
19.

Identification of inhibitors of Plasmodium falciparum gametocyte development.

Duffy S, Avery VM.

Malar J. 2013 Nov 11;12:408. doi: 10.1186/1475-2875-12-408.

20.

The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission.

Balaich JN, Mathias DK, Torto B, Jackson BT, Tao D, Ebrahimi B, Tarimo BB, Cheseto X, Foster WA, Dinglasan RR.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2108-17. doi: 10.1128/AAC.02002-15. Print 2016 Apr.

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