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Items: 1 to 20 of 99

1.

Engineering a switch-on peptide to ricin A chain for increasing its specificity towards HIV-infected cells.

Au KY, Wang RR, Wong YT, Wong KB, Zheng YT, Shaw PC.

Biochim Biophys Acta. 2014 Mar;1840(3):958-63. doi: 10.1016/j.bbagen.2013.11.005. Epub 2013 Nov 15.

PMID:
24246953
2.

A switch-on mechanism to activate maize ribosome-inactivating protein for targeting HIV-infected cells.

Law SK, Wang RR, Mak AN, Wong KB, Zheng YT, Shaw PC.

Nucleic Acids Res. 2010 Oct;38(19):6803-12. doi: 10.1093/nar/gkq551. Epub 2010 Jun 17.

4.

Major structural differences between pokeweed antiviral protein and ricin A-chain do not account for their differing ribosome specificity.

Chaddock JA, Monzingo AF, Robertus JD, Lord JM, Roberts LM.

Eur J Biochem. 1996 Jan 15;235(1-2):159-66.

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Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalk.

Li XP, Kahn PC, Kahn JN, Grela P, Tumer NE.

J Biol Chem. 2013 Oct 18;288(42):30270-84. doi: 10.1074/jbc.M113.510966. Epub 2013 Sep 3.

7.

The ribosomal stalk is required for ribosome binding, depurination of the rRNA and cytotoxicity of ricin A chain in Saccharomyces cerevisiae.

Chiou JC, Li XP, Remacha M, Ballesta JP, Tumer NE.

Mol Microbiol. 2008 Dec;70(6):1441-52. doi: 10.1111/j.1365-2958.2008.06492.x. Epub 2008 Oct 30.

8.

Generation of a potent chimeric toxin by replacement of domain III of Pseudomonas exotoxin with ricin A chain KDEL.

Pitcher C, Roberts L, Fawell S, Zdanovsky AG, FitzGerald DJ, Lord JM.

Bioconjug Chem. 1995 Sep-Oct;6(5):624-9.

PMID:
8974463
9.

Cytotoxicity of a recombinant ricin-A-chain fusion protein containing a proteolytically-cleavable spacer sequence.

O'Hare M, Brown AN, Hussain K, Gebhardt A, Watson G, Roberts LM, Vitetta ES, Thorpe PE, Lord JM.

FEBS Lett. 1990 Oct 29;273(1-2):200-4.

10.

Cytotoxic ribosome-inactivating lectins from plants.

Hartley MR, Lord JM.

Biochim Biophys Acta. 2004 Sep 1;1701(1-2):1-14. Review.

PMID:
15450171
11.

Pentameric organization of the ribosomal stalk accelerates recruitment of ricin a chain to the ribosome for depurination.

Li XP, Grela P, Krokowski D, Tchórzewski M, Tumer NE.

J Biol Chem. 2010 Dec 31;285(53):41463-71. doi: 10.1074/jbc.M110.171793. Epub 2010 Oct 25.

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14.

Structural insights into the interaction of the ribosomal P stalk protein P2 with a type II ribosome-inactivating protein ricin.

Fan X, Zhu Y, Wang C, Niu L, Teng M, Li X.

Sci Rep. 2016 Nov 25;6:37803. doi: 10.1038/srep37803.

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16.

Differences in cytotoxicity of native and engineered RIPs can be used to assess their ability to reach the cytoplasm.

Svinth M, Steighardt J, Hernandez R, Suh JK, Kelly C, Day P, Lord M, Girbes T, Robertus JD.

Biochem Biophys Res Commun. 1998 Aug 28;249(3):637-42.

PMID:
9731188
17.

A two-step binding model proposed for the electrostatic interactions of ricin a chain with ribosomes.

Li XP, Chiou JC, Remacha M, Ballesta JP, Tumer NE.

Biochemistry. 2009 May 12;48(18):3853-63. doi: 10.1021/bi802371h.

19.

Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins.

Ho MC, Sturm MB, Almo SC, Schramm VL.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20276-81. doi: 10.1073/pnas.0911606106. Epub 2009 Nov 17.

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