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Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy-lysosome-dependent way.

Xu Y, Zhang J, Tian C, Ren K, Yan YE, Wang K, Wang H, Chen C, Wang J, Shi Q, Dong XP.

Med Microbiol Immunol. 2014 Apr;203(2):73-84. doi: 10.1007/s00430-013-0316-z. Epub 2013 Nov 17.


LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells.

Jiang P, Mizushima N.

Methods. 2015 Mar;75:13-8. doi: 10.1016/j.ymeth.2014.11.021. Epub 2014 Dec 5.


Involvement of selective autophagy mediated by p62/SQSTM1 in KLHL3-dependent WNK4 degradation.

Mori Y, Mori T, Wakabayashi M, Yoshizaki Y, Zeniya M, Sohara E, Rai T, Uchida S.

Biochem J. 2015 Nov 15;472(1):33-41. doi: 10.1042/BJ20150500. Epub 2015 Sep 8.


Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein.

Homma T, Ishibashi D, Nakagaki T, Satoh K, Sano K, Atarashi R, Nishida N.

Sci Rep. 2014 Mar 28;4:4504. doi: 10.1038/srep04504.


Autophagy protein p62/SQSTM1 is involved in HAMLET-induced cell death by modulating apotosis in U87MG cells.

Zhang YB, Gong JL, Xing TY, Zheng SP, Ding W.

Cell Death Dis. 2013 Mar 21;4:e550. doi: 10.1038/cddis.2013.77.


Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction.

Zhang J, Wang K, Guo Y, Shi Q, Tian C, Chen C, Gao C, Zhang BY, Dong XP.

Virol J. 2012 Dec 6;9:303. doi: 10.1186/1743-422X-9-303.


p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.

Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T.

J Cell Biol. 2005 Nov 21;171(4):603-14. Epub 2005 Nov 14.


Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62.

Nakashima H, Nguyen T, Goins WF, Chiocca EA.

J Biol Chem. 2015 Jan 16;290(3):1485-95. doi: 10.1074/jbc.M114.593871. Epub 2014 Nov 26.


p62/sequestosome-1 up-regulation promotes ABT-263-induced caspase-8 aggregation/activation on the autophagosome.

Huang S, Okamoto K, Yu C, Sinicrope FA.

J Biol Chem. 2013 Nov 22;288(47):33654-66. doi: 10.1074/jbc.M113.518134. Epub 2013 Oct 11.


p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.

Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G, Johansen T.

J Biol Chem. 2007 Aug 17;282(33):24131-45. Epub 2007 Jun 19.


New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone.

Rea SL, Walsh JP, Layfield R, Ratajczak T, Xu J.

Endocr Rev. 2013 Aug;34(4):501-24. doi: 10.1210/er.2012-1034. Epub 2013 Apr 23. Review.


Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.

Chen S, Zhou L, Zhang Y, Leng Y, Pei XY, Lin H, Jones R, Orlowski RZ, Dai Y, Grant S.

Mol Cell Biol. 2014 Sep 15;34(18):3435-49. doi: 10.1128/MCB.01383-13. Epub 2014 Jul 7.


Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells.

Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K.

PLoS One. 2013 Jul 29;8(7):e69563. doi: 10.1371/journal.pone.0069563. Print 2013.


Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux.

Samarasinghe B, Wales CT, Taylor FR, Jacobs AT.

Biochem Pharmacol. 2014 Feb 1;87(3):445-55. doi: 10.1016/j.bcp.2013.11.014. Epub 2013 Nov 28.


Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.

Myeku N, Figueiredo-Pereira ME.

J Biol Chem. 2011 Jun 24;286(25):22426-40. doi: 10.1074/jbc.M110.149252. Epub 2011 May 2.


p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions.

Watanabe Y, Tatebe H, Taguchi K, Endo Y, Tokuda T, Mizuno T, Nakagawa M, Tanaka M.

PLoS One. 2012;7(12):e52868. doi: 10.1371/journal.pone.0052868. Epub 2012 Dec 31.


p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.

Christian F, Anthony DF, Vadrevu S, Riddell T, Day JP, McLeod R, Adams DR, Baillie GS, Houslay MD.

Cell Signal. 2010 Oct;22(10):1576-96. doi: 10.1016/j.cellsig.2010.06.003. Epub 2010 Jun 19.


p62/SQSTM1 is involved in caspase-8 associated cell death induced by proteasome inhibitor MG132 in U87MG cells.

Zeng RX, Zhang YB, Fan Y, Wu GL.

Cell Biol Int. 2014 Oct;38(10):1221-6. doi: 10.1002/cbin.10311. Epub 2014 May 19.


Structural basis for sorting mechanism of p62 in selective autophagy.

Ichimura Y, Kumanomidou T, Sou YS, Mizushima T, Ezaki J, Ueno T, Kominami E, Yamane T, Tanaka K, Komatsu M.

J Biol Chem. 2008 Aug 15;283(33):22847-57. doi: 10.1074/jbc.M802182200. Epub 2008 Jun 4.

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