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Items: 1 to 20 of 146

1.

Destabilization of the homotetrameric assembly of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from the hyperthermophile Pyrococcus furiosus enhances enzymatic activity.

Nazmi AR, Schofield LR, Dobson RC, Jameson GB, Parker EJ.

J Mol Biol. 2014 Feb 6;426(3):656-73. doi: 10.1016/j.jmb.2013.11.008. Epub 2013 Nov 14.

PMID:
24239948
2.

Substrate ambiguity and crystal structure of Pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase: an ancestral 3-deoxyald-2-ulosonate-phosphate synthase?

Schofield LR, Anderson BF, Patchett ML, Norris GE, Jameson GB, Parker EJ.

Biochemistry. 2005 Sep 13;44(36):11950-62.

PMID:
16142893
3.

The Functional Unit of Neisseria meningitidis 3-Deoxy-ᴅ-Arabino-Heptulosonate 7-Phosphate Synthase Is Dimeric.

Cross PJ, Heyes LC, Zhang S, Nazmi AR, Parker EJ.

PLoS One. 2016 Feb 1;11(2):e0145187. doi: 10.1371/journal.pone.0145187. eCollection 2016.

4.

Allosteric inhibitor specificity of Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase.

Cross PJ, Parker EJ.

FEBS Lett. 2013 Sep 17;587(18):3063-8. doi: 10.1016/j.febslet.2013.07.044. Epub 2013 Jul 31.

5.

Dynamic cross-talk among remote binding sites: the molecular basis for unusual synergistic allostery.

Jiao W, Hutton RD, Cross PJ, Jameson GB, Parker EJ.

J Mol Biol. 2012 Jan 27;415(4):716-26. doi: 10.1016/j.jmb.2011.11.037. Epub 2011 Dec 2.

PMID:
22154807
6.

Neisseria meningitidis expresses a single 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine.

Cross PJ, Pietersma AL, Allison TM, Wilson-Coutts SM, Cochrane FC, Parker EJ.

Protein Sci. 2013 Aug;22(8):1087-99. doi: 10.1002/pro.2293. Epub 2013 Jun 27.

7.

Structure and characterization of the 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Aeropyrum pernix.

Zhou L, Wu J, Janakiraman V, Shumilin IA, Bauerle R, Kretsinger RH, Woodard RW.

Bioorg Chem. 2012 Feb;40(1):79-86. doi: 10.1016/j.bioorg.2011.09.002. Epub 2011 Sep 17.

8.
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10.

Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis.

Cross PJ, Dobson RC, Patchett ML, Parker EJ.

J Biol Chem. 2011 Mar 25;286(12):10216-24. doi: 10.1074/jbc.M110.209924. Epub 2011 Jan 30.

11.

Investigating the role of the hydroxyl groups of substrate erythrose 4-phosphate in the reaction catalysed by the first enzyme of the shikimate pathway.

Tran D, Pietersma AL, Schofield LR, Rost M, Jameson GB, Parker EJ.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6838-41. doi: 10.1016/j.bmcl.2011.09.017. Epub 2011 Sep 16.

PMID:
21978677
12.

Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase - The importance of accommodating the active site water.

Heyes LC, Reichau S, Cross PJ, Jameson GB, Parker EJ.

Bioorg Chem. 2014 Dec;57:242-50. doi: 10.1016/j.bioorg.2014.08.003. Epub 2014 Aug 27.

PMID:
25245459
13.
14.

Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain.

Cross PJ, Allison TM, Dobson RC, Jameson GB, Parker EJ.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2111-6. doi: 10.1073/pnas.1217923110. Epub 2013 Jan 23.

15.

Examining the role of intersubunit contacts in catalysis by 3-deoxy-d-manno-octulosonate 8-phosphate synthase.

Allison TM, Cochrane FC, Jameson GB, Parker EJ.

Biochemistry. 2013 Jul 9;52(27):4676-86. doi: 10.1021/bi400521f. Epub 2013 Jun 26.

PMID:
23746359
16.

Stereospecific deuteration of 2-deoxyerythrose 4-phosphate using 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase.

Williamson RM, Pietersma AL, Jameson GB, Parker EJ.

Bioorg Med Chem Lett. 2005 May 2;15(9):2339-42.

PMID:
15837321
18.

Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using ᴅ-Amino Acids.

Reichau S, Blackmore NJ, Jiao W, Parker EJ.

PLoS One. 2016 Apr 29;11(4):e0152723. doi: 10.1371/journal.pone.0152723. eCollection 2016.

19.

Complex Formation between Two Biosynthetic Enzymes Modifies the Allosteric Regulatory Properties of Both: AN EXAMPLE OF MOLECULAR SYMBIOSIS.

Blackmore NJ, Nazmi AR, Hutton RD, Webby MN, Baker EN, Jameson GB, Parker EJ.

J Biol Chem. 2015 Jul 17;290(29):18187-98. doi: 10.1074/jbc.M115.638700. Epub 2015 Jun 1.

20.

Three sites and you are out: ternary synergistic allostery controls aromatic amino acid biosynthesis in Mycobacterium tuberculosis.

Blackmore NJ, Reichau S, Jiao W, Hutton RD, Baker EN, Jameson GB, Parker EJ.

J Mol Biol. 2013 May 13;425(9):1582-92. doi: 10.1016/j.jmb.2012.12.019. Epub 2012 Dec 28.

PMID:
23274137

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