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Items: 1 to 20 of 108

1.

Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.

Williams JD, Nguyen ST, Gu S, Ding X, Butler MM, Tashjian TF, Opperman TJ, Panchal RG, Bavari S, Peet NP, Moir DT, Bowlin TL.

Bioorg Med Chem. 2013 Dec 15;21(24):7790-806. doi: 10.1016/j.bmc.2013.10.014. Epub 2013 Oct 25.

2.

Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.

Nguyen ST, Williams JD, Butler MM, Ding X, Mills DM, Tashjian TF, Panchal RG, Weir SK, Moon C, Kim HO, Marsden JA, Peet NP, Bowlin TL.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3366-72. doi: 10.1016/j.bmcl.2014.05.094. Epub 2014 Jun 12.

3.

Design, Synthesis and Qualitative Structure Activity Relationship Evaluations of Quinoline-Based Bisarylimidazoles as Antibacterial Motifs.

Al-Qawasmeh RA, Huthail BB, Sinnokrot MO, Semreen MH, Odeh RA, Abu-Zarga MH, Tarazi H, Yousef IA, Al-Tel TH.

Med Chem. 2016;12(6):563-73.

PMID:
27188185
4.

Synthesis and antibacterial activity of substituted 1,2,3,4-tetrahydropyrazino [1,2-a] indoles.

Tiwari RK, Singh D, Singh J, Yadav V, Pathak AK, Dabur R, Chhillar AK, Singh R, Sharma GL, Chandra R, Verma AK.

Bioorg Med Chem Lett. 2006 Jan 15;16(2):413-6. Epub 2005 Oct 21.

PMID:
16246547
5.

From indole to pyrrole, furan, thiophene and pyridine: Search for novel small molecule inhibitors of bacterial transcription initiation complex formation.

Thach O, Mielczarek M, Ma C, Kutty SK, Yang X, Black DS, Griffith R, Lewis PJ, Kumar N.

Bioorg Med Chem. 2016 Mar 15;24(6):1171-82. doi: 10.1016/j.bmc.2016.01.040. Epub 2016 Jan 21.

PMID:
26860928
6.

Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents.

Tari LW, Li X, Trzoss M, Bensen DC, Chen Z, Lam T, Zhang J, Lee SJ, Hough G, Phillipson D, Akers-Rodriguez S, Cunningham ML, Kwan BP, Nelson KJ, Castellano A, Locke JB, Brown-Driver V, Murphy TM, Ong VS, Pillar CM, Shinabarger DL, Nix J, Lightstone FC, Wong SE, Nguyen TB, Shaw KJ, Finn J.

PLoS One. 2013 Dec 26;8(12):e84409. doi: 10.1371/journal.pone.0084409. eCollection 2013.

7.

Synthesis and antibacterial activity of pyridazino[4,3-b]indole-4-carboxylic acids carrying different substituents at N-2.

Palluotto F, Campagna F, Carotti A, Ferappi M, Rosato A, Vitali C.

Farmaco. 2002 Jan;57(1):63-9.

PMID:
11902647
8.

Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: design, synthesis and evaluation as antibacterial agent.

Wang XD, Wei W, Wang PF, Tang YT, Deng RC, Li B, Zhou SS, Zhang JW, Zhang L, Xiao ZP, Ouyang H, Zhu HL.

Bioorg Med Chem. 2014 Jul 15;22(14):3620-8. doi: 10.1016/j.bmc.2014.05.018. Epub 2014 May 20.

PMID:
24882676
9.

Synthesis and evaluation of antibacterial activity of 7-alkyloxy-4,5-dihydro-imidazo[1,2-a]quinoline derivatives.

Sun XY, Wu R, Wen X, Guo L, Zhou CP, Li J, Quan ZS, Bao J.

Eur J Med Chem. 2013 Feb;60:451-5. doi: 10.1016/j.ejmech.2012.12.034. Epub 2012 Dec 26.

PMID:
23321259
10.

Unprecedented C-2 arylation of indole with diazonium salts: Syntheses of 2,3-disubstituted indoles and their antimicrobial activity.

Daly S, Hayden K, Malik I, Porch N, Tang H, Rogelj S, Frolova LV, Lepthien K, Kornienko A, Magedov IV.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4720-3. doi: 10.1016/j.bmcl.2011.06.081. Epub 2011 Jun 25.

11.

Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.

Butler MM, Williams JD, Peet NP, Moir DT, Panchal RG, Bavari S, Shinabarger DL, Bowlin TL.

Antimicrob Agents Chemother. 2010 Sep;54(9):3974-7. doi: 10.1128/AAC.00484-10. Epub 2010 Jul 12.

12.

Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.

Opperman TJ, Williams JD, Houseweart C, Panchal RG, Bavari S, Peet NP, Moir DT, Bowlin TL.

Bioorg Med Chem. 2010 Mar 15;18(6):2123-30. doi: 10.1016/j.bmc.2010.02.005. Epub 2010 Feb 10.

PMID:
20188576
13.

Synthesis of new 9-glycosyl-4,9-dihydropyrano [3,4-b]indole-1(3H)-ones as antibacterial agents.

Kassab SE, Hegazy GH, Eid NM, Amin KM, El-Gendy AA.

Nucleosides Nucleotides Nucleic Acids. 2011 Nov;30(11):991-8. doi: 10.1080/15257770.2011.630334.

PMID:
22060560
14.

Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents.

Burchak ON, Pihive EL, Maigre L, Guinchard X, Bouhours P, Jolivalt C, Schneider D, Maurin M, Giglione C, Meinnel T, Paris JM, Denis JN.

Bioorg Med Chem. 2011 May 15;19(10):3204-15. doi: 10.1016/j.bmc.2011.03.060. Epub 2011 Apr 2.

PMID:
21515059
15.

Novel synthetic bis-indolic derivatives with antistaphylococcal activity, including against MRSA and VISA strains.

Caspar Y, Jeanty M, Blu J, Burchak O, Le Pihive E, Maigre L, Schneider D, Jolivalt C, Paris JM, Hequet A, Minassian F, Denis JN, Maurin M.

J Antimicrob Chemother. 2015;70(6):1727-37. doi: 10.1093/jac/dkv015. Epub 2015 Feb 16.

PMID:
25691323
16.

Synthesis and biological activity of novel mono-indole and mono-benzofuran inhibitors of bacterial transcription initiation complex formation.

Mielczarek M, Thomas RV, Ma C, Kandemir H, Yang X, Bhadbhade M, Black DS, Griffith R, Lewis PJ, Kumar N.

Bioorg Med Chem. 2015 Apr 15;23(8):1763-75. doi: 10.1016/j.bmc.2015.02.037. Epub 2015 Feb 25.

PMID:
25778767
17.

Optimizing the antibacterial activity of a lead structure discovered by "SAR by MS" technology.

Jefferson EA, Seth PP, Robinson DE, Winter DK, Miyaji A, Risen LM, Osgood SA, Bertrand M, Swayze EE.

Bioorg Med Chem Lett. 2004 Nov 1;14(21):5257-61.

PMID:
15454207
18.

Antibacterial activity of a novel series of 3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives--an extended structure-activity relationship study.

Mahboobi S, Eichhorn E, Winkler M, Sellmer A, Möllmann U.

Eur J Med Chem. 2008 Mar;43(3):633-56. Epub 2007 Jun 3.

PMID:
17624634
19.

Discovery of bisindolyl-substituted cycloalkane-anellated indoles as novel class of antibacterial agents against S. aureus and MRSA.

El-Sayed MT, Suzen S, Altanlar N, Ohlsen K, Hilgeroth A.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):218-21. doi: 10.1016/j.bmcl.2015.10.085. Epub 2015 Oct 29.

PMID:
26590101
20.

Axinellamines as broad-spectrum antibacterial agents: scalable synthesis and biology.

Rodriguez RA, Barrios Steed D, Kawamata Y, Su S, Smith PA, Steed TC, Romesberg FE, Baran PS.

J Am Chem Soc. 2014 Oct 29;136(43):15403-13. doi: 10.1021/ja508632y. Epub 2014 Oct 20.

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