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Items: 1 to 20 of 309

1.

Inflammatory stress induces statin resistance by disrupting 3-hydroxy-3-methylglutaryl-CoA reductase feedback regulation.

Chen Y, Ku H, Zhao L, Wheeler DC, Li LC, Li Q, Varghese Z, Moorhead JF, Powis SH, Huang A, Ruan XZ.

Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):365-76. doi: 10.1161/ATVBAHA.113.301301. Epub 2013 Nov 14.

2.

Inflammatory stress reduces the effectiveness of statins in the kidney by disrupting HMGCoA reductase feedback regulation.

Chen Y, Zhao L, Li Q, Wheeler DC, Varghese Z, Moorhead JF, Powis SH, Ruan XZ.

Nephrol Dial Transplant. 2014 Oct;29(10):1864-78. doi: 10.1093/ndt/gfu203. Epub 2014 Jun 3.

PMID:
24895437
3.

Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation.

Ma KL, Liu J, Wang CX, Ni J, Zhang Y, Wu Y, Lv LL, Ruan XZ, Liu BC.

Cardiovasc Res. 2013 Dec 1;100(3):450-60. doi: 10.1093/cvr/cvt203. Epub 2013 Sep 25.

PMID:
24068000
4.

Inflammatory stress exacerbates lipid-mediated renal injury in ApoE/CD36/SRA triple knockout mice.

Xu ZE, Chen Y, Huang A, Varghese Z, Moorhead JF, Yan F, Powis SH, Li Q, Ruan XZ.

Am J Physiol Renal Physiol. 2011 Oct;301(4):F713-22. doi: 10.1152/ajprenal.00341.2010. Epub 2011 Jul 27.

5.

Essential role of TGF-beta/Smad pathway on statin dependent vascular smooth muscle cell regulation.

Rodríguez-Vita J, Sánchez-Galán E, Santamaría B, Sánchez-López E, Rodrigues-Díez R, Blanco-Colio LM, Egido J, Ortiz A, Ruiz-Ortega M.

PLoS One. 2008;3(12):e3959. doi: 10.1371/journal.pone.0003959. Epub 2008 Dec 17.

6.

Statins have biphasic effects on angiogenesis.

Weis M, Heeschen C, Glassford AJ, Cooke JP.

Circulation. 2002 Feb 12;105(6):739-45.

7.

Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux.

Argmann CA, Edwards JY, Sawyez CG, O'Neil CH, Hegele RA, Pickering JG, Huff MW.

J Biol Chem. 2005 Jun 10;280(23):22212-21. Epub 2005 Apr 6.

8.

Difference in LDL receptor feedback regulation in macrophages and vascular smooth muscle cells: foam cell transformation under inflammatory stress.

Ye Q, Lei H, Fan Z, Zheng W, Zheng S.

Inflammation. 2014 Apr;37(2):555-65. doi: 10.1007/s10753-013-9769-x.

PMID:
24297394
9.

Atorvastatin decreases C-reactive protein-induced inflammatory response in pulmonary artery smooth muscle cells by inhibiting nuclear factor-kappaB pathway.

Li J, Li JJ, He JG, Nan JL, Guo YL, Xiong CM.

Cardiovasc Ther. 2010 Spring;28(1):8-14. doi: 10.1111/j.1755-5922.2009.00103.x.

PMID:
20074254
10.

High doses of atorvastatin and simvastatin induce key enzymes involved in VLDL production.

Roglans N, Verd JC, Peris C, Alegret M, Vázquez M, Adzet T, Díaz C, Hernández G, Laguna JC, Sánchez RM.

Lipids. 2002 May;37(5):445-54.

PMID:
12056585
11.

Atorvastatin sensitises vascular smooth muscle cells, but not endothelial cells, to TNF-α-induced cell death.

Giordano A, Romano S, Nappo G, Messina S, Polimeno M, Corcione N, Cali G, Ferraro P, Monaco M, Zambrano N, Romano MF.

Curr Pharm Des. 2012;18(38):6331-8.

PMID:
23092297
12.

3-hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells.

Wagner AH, Gebauer M, Güldenzoph B, Hecker M.

Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1784-9.

13.

Tissue-specific effects of atorvastatin on 3-hydroxy-3-methylglutarylcoenzyme A reductase expression and activity in spontaneously hypertensive rats.

Chen GP, Yao L, Lu X, Li L, Hu SJ.

Acta Pharmacol Sin. 2008 Oct;29(10):1181-6. doi: 10.1111/j.1745-7254.2008.00855.x.

14.
15.

Inflammatory cytokines disrupt LDL-receptor feedback regulation and cause statin resistance: a comparative study in human hepatic cells and mesangial cells.

Chen Y, Ruan XZ, Li Q, Huang A, Moorhead JF, Powis SH, Varghese Z.

Am J Physiol Renal Physiol. 2007 Sep;293(3):F680-7. Epub 2007 Jul 18.

16.

Effect of atorvastatin on the expression of gamma-glutamyl transferase in aortic atherosclerotic plaques of apolipoprotein E-knockout mice.

Li G, Wu XW, Lu WH, Ai R, Chen F, Tang ZZ.

BMC Cardiovasc Disord. 2014 Oct 18;14:145. doi: 10.1186/1471-2261-14-145.

17.

Up-regulation of hepatic low-density lipoprotein receptor-related protein 1: a possible novel mechanism of antiatherogenic activity of hydroxymethylglutaryl-coenzyme A reductase inhibitor Atorvastatin and hepatic LRP1 expression.

Moon JH, Kang SB, Park JS, Lee BW, Kang ES, Ahn CW, Lee HC, Cha BS.

Metabolism. 2011 Jul;60(7):930-40. doi: 10.1016/j.metabol.2010.08.013. Epub 2010 Oct 15.

PMID:
20951395
18.

Enhanced SCAP glycosylation by inflammation induces macrophage foam cell formation.

Zhou C, Lei H, Chen Y, Liu Q, Li LC, Moorhead JF, Varghese Z, Ruan XZ.

PLoS One. 2013 Oct 16;8(10):e75650. doi: 10.1371/journal.pone.0075650. eCollection 2013.

19.

Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators.

Kizu A, Shioi A, Jono S, Koyama H, Okuno Y, Nishizawa Y.

J Cell Biochem. 2004 Nov 15;93(5):1011-9.

PMID:
15389884
20.

Atorvastatin inhibits inflammatory hypernociception.

Santodomingo-Garzón T, Cunha TM, Verri WA Jr, Valério DA, Parada CA, Poole S, Ferreira SH, Cunha FQ.

Br J Pharmacol. 2006 Sep;149(1):14-22. Epub 2006 Jul 24.

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