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Korean Red Ginseng protects endothelial cells from serum-deprived apoptosis by regulating Bcl-2 family protein dynamics and caspase S-nitrosylation.

Kim YM, Kim JH, Kwon HM, Lee DH, Won MH, Kwon YG, Kim YM.

J Ginseng Res. 2013 Oct;37(4):413-24. doi: 10.5142/jgr.2013.37.413.


Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3K/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells.

Kim YM, Namkoong S, Yun YG, Hong HD, Lee YC, Ha KS, Lee H, Kwon HJ, Kwon YG, Kim YM.

Biol Pharm Bull. 2007 Sep;30(9):1674-9.


Korean red ginseng extract induces proliferation to differentiation transition of human acute promyelocytic leukemia cells via MYC-SKP2-CDKN1B axis.

Jo S, Lee H, Kim S, Lee CH, Chung H.

J Ethnopharmacol. 2013 Nov 25;150(2):700-7. doi: 10.1016/j.jep.2013.09.036. Epub 2013 Oct 2.


Inhibition of Hydrogen Sulfide-induced Angiogenesis and Inflammation in Vascular Endothelial Cells: Potential Mechanisms of Gastric Cancer Prevention by Korean Red Ginseng.

Choi KS, Song H, Kim EH, Choi JH, Hong H, Han YM, Hahm KB.

J Ginseng Res. 2012 Apr;36(2):135-45. doi: 10.5142/jgr.2012.36.2.135.


Korean red ginseng water extract restores impaired endothelial function by inhibiting arginase activity in aged mice.

Choi K, Yoon J, Lim HK, Ryoo S.

Korean J Physiol Pharmacol. 2014 Apr;18(2):95-101. doi: 10.4196/kjpp.2014.18.2.95. Epub 2014 Apr 3.


Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway.

Ahsan A, Han G, Pan J, Liu S, Padhiar AA, Chu P, Sun Z, Zhang Z, Sun B, Wu J, Irshad A, Lin Y, Peng J, Tang Z.

Apoptosis. 2015 Dec;20(12):1563-76. doi: 10.1007/s10495-015-1175-4.


Korean Red Ginseng Extract Enhances the Anticancer Effects of Imatinib Mesylate Through Abrogation p38 and STAT5 Activation in KBM-5 Cells.

Jung SY, Kim C, Kim WS, Lee SG, Lee JH, Shim BS, Kim SH, Ahn KS, Ahn KS.

Phytother Res. 2015 Jul;29(7):1062-72. doi: 10.1002/ptr.5347. Epub 2015 Apr 8.


20(S)-Ginsenoside Rg3 prevents endothelial cell apoptosis via inhibition of a mitochondrial caspase pathway.

Min JK, Kim JH, Cho YL, Maeng YS, Lee SJ, Pyun BJ, Kim YM, Park JH, Kwon YG.

Biochem Biophys Res Commun. 2006 Oct 27;349(3):987-94. Epub 2006 Aug 30.


Korean Red Ginseng Extract Enhances the Anticancer Effects of Sorafenib through Abrogation of CREB and c-Jun Activation in Renal Cell Carcinoma.

Kim C, Lee JH, Baek SH, Ko JH, Nam D, Ahn KS.

Phytother Res. 2017 Jul;31(7):1078-1089. doi: 10.1002/ptr.5829. Epub 2017 May 22.


Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide.

Hoffmann J, Haendeler J, Aicher A, Rössig L, Vasa M, Zeiher AM, Dimmeler S.

Circ Res. 2001 Oct 12;89(8):709-15.


High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway.

Ho FM, Lin WW, Chen BC, Chao CM, Yang CR, Lin LY, Lai CC, Liu SH, Liau CS.

Cell Signal. 2006 Mar;18(3):391-9. Epub 2005 Jun 20.


Andrographolide suppresses endothelial cell apoptosis via activation of phosphatidyl inositol-3-kinase/Akt pathway.

Chen JH, Hsiao G, Lee AR, Wu CC, Yen MH.

Biochem Pharmacol. 2004 Apr 1;67(7):1337-45.


Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production.

Kwon YG, Min JK, Kim KM, Lee DJ, Billiar TR, Kim YM.

J Biol Chem. 2001 Apr 6;276(14):10627-33. Epub 2000 Dec 28.


Enzyme-processed Korean Red Ginseng extracts protects against skin damage induced by UVB irradiation in hairless mice.

Hwang E, Sun ZW, Lee TH, Shin HS, Park SY, Lee DG, Cho BG, Sohn H, Kwon OW, Kim SY, Yi TH.

J Ginseng Res. 2013 Oct;37(4):425-34. doi: 10.5142/jgr.2013.37.425.


Nitric oxide protects PC12 cells from serum deprivation-induced apoptosis by cGMP-dependent inhibition of caspase signaling.

Kim YM, Chung HT, Kim SS, Han JA, Yoo YM, Kim KM, Lee GH, Yun HY, Green A, Li J, Simmons RL, Billiar TR.

J Neurosci. 1999 Aug 15;19(16):6740-7.


The protective effect of Bcl-xl overexpression against oxidative stress-induced vascular endothelial cell injury and the role of the Akt/eNOS pathway.

Ni L, Li T, Liu B, Song X, Yang G, Wang L, Miao S, Liu C.

Int J Mol Sci. 2013 Nov 8;14(11):22149-62. doi: 10.3390/ijms141122149.


Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid β-protein via the PI3K/Akt/Bad/Bcl(XL)-regulated mitochondrial apoptotic pathway.

Zeng KW, Wang XM, Ko H, Kwon HC, Cha JW, Yang HO.

Eur J Pharmacol. 2011 Dec 15;672(1-3):45-55. doi: 10.1016/j.ejphar.2011.09.177. Epub 2011 Sep 29.


Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of S-nitrosohomocysteine.

Lee SJ, Kim KM, Namkoong S, Kim CK, Kang YC, Lee H, Ha KS, Han JA, Chung HT, Kwon YG, Kim YM.

J Biol Chem. 2005 Feb 18;280(7):5781-8. Epub 2004 Nov 23.

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