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Coxsackievirus A16: epidemiology, diagnosis, and vaccine.

Mao Q, Wang Y, Yao X, Bian L, Wu X, Xu M, Liang Z.

Hum Vaccin Immunother. 2014;10(2):360-7. doi: 10.4161/hv.27087. Epub 2013 Nov 14. Review.


[Detection of enterovirus 71 and coxsackievirus A16 from children with hand, foot and mouth disease in Shanghai, 2002].

Yang ZH, Zhu QR, Li XZ, Wang XH, Wang JS, Hu JY, Tang W, Cui AL.

Zhonghua Er Ke Za Zhi. 2005 Sep;43(9):648-52. Chinese.


Epidemic characteristics of hand, foot, and mouth disease in Shanghai from 2009 to 2010: Enterovirus 71 subgenotype C4 as the primary causative agent and a high incidence of mixed infections with coxsackievirus A16.

Yan XF, Gao S, Xia JF, Ye R, Yu H, Long JE.

Scand J Infect Dis. 2012 Apr;44(4):297-305. doi: 10.3109/00365548.2011.634433. Epub 2011 Dec 18.


A novel inactivated enterovirus 71 vaccine can elicit cross-protective immunity against coxsackievirus A16 in mice.

Yang L, Liu Y, Li S, Zhao H, Lin Q, Yu H, Huang X, Zheng Q, Cheng T, Xia N.

Vaccine. 2016 Nov 21;34(48):5938-5945. doi: 10.1016/j.vaccine.2016.10.018. Epub 2016 Oct 19.


The compatibility of inactivated-Enterovirus 71 vaccination with Coxsackievirus A16 and Poliovirus immunizations in humans and animals.

Mao Q, Wang Y, Shao J, Ying Z, Gao F, Yao X, Li C, Ye Q, Xu M, Li R, Zhu F, Liang Z.

Hum Vaccin Immunother. 2015;11(11):2723-33. doi: 10.1080/21645515.2015.1011975. Epub 2015 Feb 25.


Seroprevalence of human enterovirus 71 and coxsackievirus A16 in Guangdong, China, in pre- and post-2010 HFMD epidemic period.

Li W, Yi L, Su J, Lu J, Ke C, Zeng H, Guan D, Ma C, Zhang W, Xiao H, Li H, Lin J, Zhang Y.

PLoS One. 2013 Dec 4;8(12):e80515. doi: 10.1371/journal.pone.0080515. eCollection 2013.


Characterization of severe hand, foot, and mouth disease in Shenzhen, China, 2009-2013.

Huang Y, Zhou Y, Lu H, Yang H, Feng Q, Dai Y, Chen L, Yu S, Yao X, Zhang H, Jiang M, Wang Y, Han N, Hu G, He Y.

J Med Virol. 2015 Sep;87(9):1471-9. doi: 10.1002/jmv.24200. Epub 2015 May 7.


Coxsackievirus A6: a new emerging pathogen causing hand, foot and mouth disease outbreaks worldwide.

Bian L, Wang Y, Yao X, Mao Q, Xu M, Liang Z.

Expert Rev Anti Infect Ther. 2015;13(9):1061-71. doi: 10.1586/14787210.2015.1058156. Epub 2015 Jun 25. Review.


A combination vaccine comprising of inactivated enterovirus 71 and coxsackievirus A16 elicits balanced protective immunity against both viruses.

Cai Y, Ku Z, Liu Q, Leng Q, Huang Z.

Vaccine. 2014 May 1;32(21):2406-12. doi: 10.1016/j.vaccine.2014.03.012. Epub 2014 Mar 18.


Enterovirus spectrum from the active surveillance of hand foot and mouth disease patients under the clinical trial of inactivated Enterovirus A71 vaccine in Jiangsu, China, 2012-2013.

Yao X, Bian LL, Lu WW, Li JX, Mao QY, Wang YP, Gao F, Wu X, Ye Q, Xu M, Li XL, Zhu FC, Liang ZL.

J Med Virol. 2015 Dec;87(12):2009-17. doi: 10.1002/jmv.24275. Epub 2015 Jun 9.


Phylogenetic analysis of the major causative agents of hand, foot and mouth disease in Suzhou City, Jiangsu province, China, in 2012-2013.

Zhang C, Zhu R, Yang Y, Chi Y, Yin J, Tang X, Yu L, Zhang C, Huang Z, Zhou D.

Emerg Microbes Infect. 2015 Feb;4(2):e12. doi: 10.1038/emi.2015.12. Epub 2015 Feb 25.


Co-circulation and genomic recombination of coxsackievirus A16 and enterovirus 71 during a large outbreak of hand, foot, and mouth disease in Central China.

Liu W, Wu S, Xiong Y, Li T, Wen Z, Yan M, Qin K, Liu Y, Wu J.

PLoS One. 2014 Apr 28;9(4):e96051. doi: 10.1371/journal.pone.0096051. eCollection 2014.


EV71 vaccines: a first step towards multivalent hand, foot and mouth disease vaccines.

Klein MH.

Expert Rev Vaccines. 2015 Mar;14(3):337-40. doi: 10.1586/14760584.2015.993385. Epub 2014 Dec 24.


EV71 vaccine, a new tool to control outbreaks of hand, foot and mouth disease (HFMD).

Mao QY, Wang Y, Bian L, Xu M, Liang Z.

Expert Rev Vaccines. 2016 May;15(5):599-606. doi: 10.1586/14760584.2016.1138862. Epub 2016 Jan 14. Review.


Hexon-modified recombinant E1-deleted adenoviral vectors as bivalent vaccine carriers for Coxsackievirus A16 and Enterovirus 71.

Zhang C, Yang Y, Chi Y, Yin J, Yan L, Ku Z, Liu Q, Huang Z, Zhou D.

Vaccine. 2015 Sep 22;33(39):5087-94. doi: 10.1016/j.vaccine.2015.08.016. Epub 2015 Aug 19.


Epidemiological and etiological characteristics of hand, foot, and mouth disease in Ningbo, China, 2008-2011.

Ni H, Yi B, Yin J, Fang T, He T, Du Y, Wang J, Zhang H, Xie L, Ding Y, Gu W, Zhang S, Han Y, Dong H, Su T, Xu G, Cao G.

J Clin Virol. 2012 Aug;54(4):342-8. doi: 10.1016/j.jcv.2012.04.021. Epub 2012 May 30.


Status of research and development of vaccines for enterovirus 71.

Reed Z, Cardosa MJ.

Vaccine. 2016 Jun 3;34(26):2967-2970. doi: 10.1016/j.vaccine.2016.02.077. Epub 2016 Mar 11.


Evaluation of monovalent and bivalent vaccines against lethal Enterovirus 71 and Coxsackievirus A16 infection in newborn mice.

Sun S, Jiang L, Liang Z, Mao Q, Su W, Zhang H, Li X, Jin J, Xu L, Zhao D, Fan P, An D, Yang P, Lu J, Lv X, Sun B, Xu F, Kong W, Jiang C.

Hum Vaccin Immunother. 2014;10(10):2885-95. doi: 10.4161/hv.29823.


A one-step, triplex, real-time RT-PCR assay for the simultaneous detection of enterovirus 71, coxsackie A16 and pan-enterovirus in a single tube.

Zhang S, Wang J, Yan Q, He S, Zhou W, Ge S, Xia N.

PLoS One. 2014 Jul 16;9(7):e102724. doi: 10.1371/journal.pone.0102724. eCollection 2014.


Seroepidemiology of human enterovirus71 and coxsackievirusA16 among children in Guangdong province, China.

Li W, Yi L, Su J, Lu J, Zeng H, Guan D, Ma C, Zhang W, Xiao H, Li H, Zhang Y, Lin J, Ke C.

BMC Infect Dis. 2013 Jul 15;13:322. doi: 10.1186/1471-2334-13-322.

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