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Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors.

Zhao H, Bauzon F, Fu H, Lu Z, Cui J, Nakayama K, Nakayama KI, Locker J, Zhu L.

Cancer Cell. 2013 Nov 11;24(5):645-59. doi: 10.1016/j.ccr.2013.09.021.


Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice.

Wang H, Bauzon F, Ji P, Xu X, Sun D, Locker J, Sellers RS, Nakayama K, Nakayama KI, Cobrinik D, Zhu L.

Nat Genet. 2010 Jan;42(1):83-8. doi: 10.1038/ng.498. Epub 2009 Dec 6.


Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age.

Zhao H, Bauzon F, Bi E, Yu JJ, Fu H, Lu Z, Cui J, Jeon H, Zang X, Ye BH, Zhu L.

J Biol Chem. 2015 Feb 27;290(9):5797-809. doi: 10.1074/jbc.M114.625350. Epub 2015 Jan 12.


Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model.

Li X, Yokoyama NN, Zhang S, Ding L, Liu HM, Lilly MB, Mercola D, Zi X.

Oncotarget. 2015 Dec 8;6(39):41809-24. doi: 10.18632/oncotarget.6166.


Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.

Lin HK, Chen Z, Wang G, Nardella C, Lee SW, Chan CH, Yang WL, Wang J, Egia A, Nakayama KI, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP.

Nature. 2010 Mar 18;464(7287):374-9. doi: 10.1038/nature08815. Erratum in: Nature. 2010 Jul 15;466(7304):398. Chan, Chan-Hsin [corrected to Chan, Chia-Hsin].


Racing to block tumorigenesis after pRb loss: an innocuous point mutation wins with synthetic lethality.

Bauzon F, Zhu L.

Cell Cycle. 2010 Jun 1;9(11):2118-23. Epub 2010 Jun 1. Review.


Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis.

Zhao H, Wang H, Bauzon F, Lu Z, Fu H, Cui J, Zhu L.

J Biol Chem. 2016 May 6;291(19):10201-9. doi: 10.1074/jbc.M116.718049. Epub 2016 Mar 10.


Low levels of p27 in association with deregulated p53-pRb protein status enhance tumor proliferation and chromosomal instability in non-small cell lung carcinomas.

Tsoli E, Gorgoulis VG, Zacharatos P, Kotsinas A, Mariatos G, Kastrinakis NG, Kokotas S, Kanavaros P, Asimacopoulos P, Bramis J, Kletsas D, Papavassiliou AG, Kittas C.

Mol Med. 2001 Jun;7(6):418-29.


Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27(Kip1) accumulation.

Sistrunk C, Kim SH, Wang X, Lee SH, Kim Y, Macias E, Rodriguez-Puebla ML.

Am J Pathol. 2013 May;182(5):1854-64. doi: 10.1016/j.ajpath.2013.01.016. Epub 2013 Mar 6.


Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1.

Hattori T, Isobe T, Abe K, Kikuchi H, Kitagawa K, Oda T, Uchida C, Kitagawa M.

Cancer Res. 2007 Nov 15;67(22):10789-95.


The atr protein kinase controls UV-dependent upregulation of p16INK4A through inhibition of Skp2-related polyubiquitination/degradation.

Al-Khalaf HH, Hendrayani SF, Aboussekhra A.

Mol Cancer Res. 2011 Mar;9(3):311-9. doi: 10.1158/1541-7786.MCR-10-0506. Epub 2011 Jan 26.


Skp2 regulates G2/M progression in a p53-dependent manner.

Hu R, Aplin AE.

Mol Biol Cell. 2008 Nov;19(11):4602-10. doi: 10.1091/mbc.E07-11-1137. Epub 2008 Aug 20.


Requirement for p27(KIP1) in retinoblastoma protein-mediated senescence.

Alexander K, Hinds PW.

Mol Cell Biol. 2001 Jun;21(11):3616-31.


Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.

Lu Z, Bauzon F, Fu H, Cui J, Zhao H, Nakayama K, Nakayama KI, Zhu L.

Nat Commun. 2014 Mar 17;5:3463. doi: 10.1038/ncomms4463.


The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells.

Lu L, Schulz H, Wolf DA.

BMC Cell Biol. 2002 Aug 20;3:22. Epub 2002 Aug 20.


Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit.

Binné UK, Classon MK, Dick FA, Wei W, Rape M, Kaelin WG Jr, Näär AM, Dyson NJ.

Nat Cell Biol. 2007 Feb;9(2):225-32. Epub 2006 Dec 24. Erratum in: Nat Cell Biol. 2007 Mar;9(3):353.


Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate.

Shim EH, Johnson L, Noh HL, Kim YJ, Sun H, Zeiss C, Zhang H.

Cancer Res. 2003 Apr 1;63(7):1583-8.


Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulation.

Vairo G, Soos TJ, Upton TM, Zalvide J, DeCaprio JA, Ewen ME, Koff A, Adams JM.

Mol Cell Biol. 2000 Jul;20(13):4745-53.


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