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Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma.

Crowther AJ, Gama V, Bevilacqua A, Chang SX, Yuan H, Deshmukh M, Gershon TR.

J Neurosci. 2013 Nov 13;33(46):18098-108. doi: 10.1523/JNEUROSCI.2602-13.2013.


Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation.

Garcia I, Crowther AJ, Gama V, Miller CR, Deshmukh M, Gershon TR.

Oncogene. 2013 May 2;32(18):2304-14. doi: 10.1038/onc.2012.248. Epub 2012 Jun 18. Erratum in: Oncogene. 2015 Jul;34(29):3881. Miller, C Ryan [Corrected to Miller, C R].


Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors.

Nakamura A, Swahari V, Plestant C, Smith I, McCoy E, Smith S, Moy SS, Anton ES, Deshmukh M.

J Neurosci. 2016 May 18;36(20):5448-61. doi: 10.1523/JNEUROSCI.4247-15.2016.


Bcl-xL stimulates Bax relocation to mitochondria and primes cells to ABT-737.

Renault TT, Teijido O, Missire F, Ganesan YT, Velours G, Arokium H, Beaumatin F, Llanos R, Athané A, Camougrand N, Priault M, Antonsson B, Dejean LM, Manon S.

Int J Biochem Cell Biol. 2015 Jul;64:136-46. doi: 10.1016/j.biocel.2015.03.020. Epub 2015 Apr 8.


RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines.

Levesley J, Lusher ME, Lindsey JC, Clifford SC, Grundy R, Coyle B.

Neuro Oncol. 2011 Dec;13(12):1265-76. doi: 10.1093/neuonc/nor129. Epub 2011 Aug 31.


Bax activation by engagement with, then release from, the BH3 binding site of Bcl-xL.

Gautier F, Guillemin Y, Cartron PF, Gallenne T, Cauquil N, Le Diguarher T, Casara P, Vallette FM, Manon S, Hickman JA, Geneste O, Juin P.

Mol Cell Biol. 2011 Feb;31(4):832-44. doi: 10.1128/MCB.00161-10. Epub 2010 Dec 20.


Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice.

Williams SE, Garcia I, Crowther AJ, Li S, Stewart A, Liu H, Lough KJ, O'Neill S, Veleta K, Oyarzabal EA, Merrill JR, Shih YY, Gershon TR.

Development. 2015 Nov 15;142(22):3921-32. doi: 10.1242/dev.124271. Epub 2015 Oct 8.


BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.

Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Yin XM, Hayashi N.

J Biol Chem. 2011 Apr 22;286(16):13905-13. doi: 10.1074/jbc.M110.195370. Epub 2011 Mar 2.


The multidomain proapoptotic molecules Bax and Bak are directly activated by heat.

Pagliari LJ, Kuwana T, Bonzon C, Newmeyer DD, Tu S, Beere HM, Green DR.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17975-80. Epub 2005 Dec 5.


Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.

Josefsson EC, James C, Henley KJ, Debrincat MA, Rogers KL, Dowling MR, White MJ, Kruse EA, Lane RM, Ellis S, Nurden P, Mason KD, O'Reilly LA, Roberts AW, Metcalf D, Huang DC, Kile BT.

J Exp Med. 2011 Sep 26;208(10):2017-31. doi: 10.1084/jem.20110750. Epub 2011 Sep 12.


After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.

Ding J, Mooers BH, Zhang Z, Kale J, Falcone D, McNichol J, Huang B, Zhang XC, Xing C, Andrews DW, Lin J.

J Biol Chem. 2014 Apr 25;289(17):11873-96. doi: 10.1074/jbc.M114.552562. Epub 2014 Mar 10.


WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma.

Rogers HA, Sousa S, Salto C, Arenas E, Coyle B, Grundy RG.

Br J Cancer. 2012 Sep 25;107(7):1144-52. doi: 10.1038/bjc.2012.377. Epub 2012 Aug 28.


ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation.

Lang PY, Nanjangud GJ, Sokolsky-Papkov M, Shaw C, Hwang D, Parker JS, Kabanov AV, Gershon TR.

Development. 2016 Nov 1;143(21):4038-4052.


WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation.

Anne SL, Govek EE, Ayrault O, Kim JH, Zhu X, Murphy DA, Van Aelst L, Roussel MF, Hatten ME.

PLoS One. 2013 Nov 26;8(11):e81769. doi: 10.1371/journal.pone.0081769. eCollection 2013.


Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis.

Bleicken S, Wagner C, García-Sáez AJ.

Biophys J. 2013 Jan 22;104(2):421-31. doi: 10.1016/j.bpj.2012.12.010.


Radiation Sensitivity in a Preclinical Mouse Model of Medulloblastoma Relies on the Function of the Intrinsic Apoptotic Pathway.

Crowther AJ, Ocasio JK, Fang F, Meidinger J, Wu J, Deal AM, Chang SX, Yuan H, Schmid R, Davis I, Gershon TR.

Cancer Res. 2016 Jun 1;76(11):3211-23. doi: 10.1158/0008-5472.CAN-15-0025. Epub 2016 Apr 13.


Hedgehog regulates cerebellar progenitor cell and medulloblastoma apoptosis.

Noguchi KK, Cabrera OH, Swiney BS, Salinas-Contreras P, Smith JK, Farber NB.

Neurobiol Dis. 2015 Nov;83:35-43. doi: 10.1016/j.nbd.2015.08.020. Epub 2015 Aug 28.


Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma.

Gillissen B, Wendt J, Richter A, Richter A, Müer A, Overkamp T, Gebhardt N, Preissner R, Belka C, Dörken B, Daniel PT.

J Cell Biol. 2010 Mar 22;188(6):851-62. doi: 10.1083/jcb.200912070.

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