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Items: 1 to 20 of 109

1.

Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of σ70 domain 1.1.

Bae B, Davis E, Brown D, Campbell EA, Wigneshweraraj S, Darst SA.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19772-7. doi: 10.1073/pnas.1314576110. Epub 2013 Nov 11.

2.

Inhibition of Escherichia coli RNAp by T7 Gp2 protein: role of negatively charged strip of amino acid residues in Gp2.

Sheppard C, Cámara B, Shadrin A, Akulenko N, Liu M, Baldwin G, Severinov K, Cota E, Matthews S, Wigneshweraraj SR.

J Mol Biol. 2011 Apr 15;407(5):623-32. doi: 10.1016/j.jmb.2011.02.013. Epub 2011 Feb 18.

PMID:
21316373
3.

Substitutions in the Escherichia coli RNA polymerase inhibitor T7 Gp2 that allow inhibition of transcription when the primary interaction interface between Gp2 and RNA polymerase becomes compromised.

Shadrin A, Sheppard C, Severinov K, Matthews S, Wigneshweraraj S.

Microbiology. 2012 Nov;158(Pt 11):2753-64. doi: 10.1099/mic.0.062547-0. Epub 2012 Sep 13.

4.

T7 phage protein Gp2 inhibits the Escherichia coli RNA polymerase by antagonizing stable DNA strand separation near the transcription start site.

Cámara B, Liu M, Reynolds J, Shadrin A, Liu B, Kwok K, Simpson P, Weinzierl R, Severinov K, Cota E, Matthews S, Wigneshweraraj SR.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2247-52. doi: 10.1073/pnas.0907908107. Epub 2010 Jan 19.

5.

Structural and mechanistic basis for the inhibition of Escherichia coli RNA polymerase by T7 Gp2.

James E, Liu M, Sheppard C, Mekler V, Cámara B, Liu B, Simpson P, Cota E, Severinov K, Matthews S, Wigneshweraraj S.

Mol Cell. 2012 Sep 14;47(5):755-66. doi: 10.1016/j.molcel.2012.06.013. Epub 2012 Jul 19.

6.

T7 phage factor required for managing RpoS in Escherichia coli.

Tabib-Salazar A, Liu B, Barker D, Burchell L, Qimron U, Matthews SJ, Wigneshweraraj S.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5353-E5362. doi: 10.1073/pnas.1800429115. Epub 2018 May 22.

7.

Structure of Escherichia coli RNA polymerase holoenzyme at last.

Rothman-Denes LB.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19662-3. doi: 10.1073/pnas.1320604110. Epub 2013 Nov 22. No abstract available.

8.

X-ray crystal structure of Escherichia coli RNA polymerase σ70 holoenzyme.

Murakami KS.

J Biol Chem. 2013 Mar 29;288(13):9126-34. doi: 10.1074/jbc.M112.430900. Epub 2013 Feb 6.

9.

The role of the T7 Gp2 inhibitor of host RNA polymerase in phage development.

Savalia D, Robins W, Nechaev S, Molineux I, Severinov K.

J Mol Biol. 2010 Sep 10;402(1):118-26. doi: 10.1016/j.jmb.2010.07.012. Epub 2010 Jul 19.

10.

Host RNA polymerase inhibitors encoded by ϕKMV-like phages of Pseudomonas.

Klimuk E, Akulenko N, Makarova KS, Ceyssens PJ, Volchenkov I, Lavigne R, Severinov K.

Virology. 2013 Feb 5;436(1):67-74. doi: 10.1016/j.virol.2012.10.021. Epub 2012 Nov 3.

11.

Inhibition of Escherichia coli RNA polymerase by bacteriophage T7 gene 2 protein.

Nechaev S, Severinov K.

J Mol Biol. 1999 Jun 18;289(4):815-26. Erratum in: J Mol Biol 1999 Sep 24;292(3):759.

PMID:
10369763
12.

Molecular mechanism of transcription inhibition by phage T7 gp2 protein.

Mekler V, Minakhin L, Sheppard C, Wigneshweraraj S, Severinov K.

J Mol Biol. 2011 Nov 11;413(5):1016-27. doi: 10.1016/j.jmb.2011.09.029. Epub 2011 Sep 21.

13.

Regulated communication between the upstream face of RNA polymerase and the beta' subunit jaw domain.

Wigneshweraraj SR, Burrows PC, Nechaev S, Zenkin N, Severinov K, Buck M.

EMBO J. 2004 Oct 27;23(21):4264-74. Epub 2004 Oct 7.

14.

A non-bacterial transcription factor inhibits bacterial transcription by a multipronged mechanism.

Sheppard C, James E, Barton G, Matthews S, Severinov K, Wigneshweraraj S.

RNA Biol. 2013 Apr;10(4):495-501. doi: 10.4161/rna.24283. Epub 2013 Apr 1.

15.

Exploring the potential of T7 bacteriophage protein Gp2 as a novel inhibitor of mycobacterial RNA polymerase.

du Plessis J, Cloete R, Burchell L, Sarkar P, Warren RM, Christoffels A, Wigneshweraraj S, Sampson SL.

Tuberculosis (Edinb). 2017 Sep;106:82-90. doi: 10.1016/j.tube.2017.07.004. Epub 2017 Jul 18.

PMID:
28802409
16.

Overexpression of Escherichia coli udk mimics the absence of T7 Gp2 function and thereby abrogates successful infection by T7 phage.

Shadrin A, Sheppard C, Savalia D, Severinov K, Wigneshweraraj S.

Microbiology. 2013 Feb;159(Pt 2):269-74. doi: 10.1099/mic.0.064527-0. Epub 2012 Dec 14.

17.

Interaction of Escherichia coli RNA polymerase σ70 subunit with promoter elements in the context of free σ70, RNA polymerase holoenzyme, and the β'-σ70 complex.

Mekler V, Pavlova O, Severinov K.

J Biol Chem. 2011 Jan 7;286(1):270-9. doi: 10.1074/jbc.M110.174102. Epub 2010 Oct 15.

18.

Reprint of: inhibition of Escherichia coli RNAp by T7 Gp2 protein: role of negatively charged strip of amino acid residues in Gp2.

Sheppard C, Cámara B, Shadrin A, Akulenko N, Liu M, Baldwin G, Severinov K, Cota E, Matthews S, Wigneshweraraj SR.

J Mol Biol. 2011 Oct 7;412(5):832-41. doi: 10.1016/j.jmb.2011.07.064. Epub 2011 Jul 30.

PMID:
21819993
19.

Crystal structure of the Escherichia coli regulator of sigma70, Rsd, in complex with sigma70 domain 4.

Patikoglou GA, Westblade LF, Campbell EA, Lamour V, Lane WJ, Darst SA.

J Mol Biol. 2007 Sep 21;372(3):649-59. Epub 2007 Jul 3.

20.

Full shut-off of Escherichia coli RNA-polymerase by T7 phage requires a small phage-encoded DNA-binding protein.

Tabib-Salazar A, Liu B, Shadrin A, Burchell L, Wang Z, Wang Z, Goren MG, Yosef I, Qimron U, Severinov K, Matthews SJ, Wigneshweraraj S.

Nucleic Acids Res. 2017 Jul 27;45(13):7697-7707. doi: 10.1093/nar/gkx370.

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