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Items: 1 to 20 of 91

1.

Oncogenic deletion mutants of gp130 signal from intracellular compartments.

Schmidt-Arras D, Müller M, Stevanovic M, Horn S, Schütt A, Bergmann J, Wilkens R, Lickert A, Rose-John S.

J Cell Sci. 2014 Jan 15;127(Pt 2):341-53. doi: 10.1242/jcs.130294. Epub 2013 Nov 8.

2.

Intracellular signaling prevents effective blockade of oncogenic gp130 mutants by neutralizing antibodies.

Rinis N, Küster A, Schmitz-Van de Leur H, Mohr A, Müller-Newen G.

Cell Commun Signal. 2014 Mar 10;12:14. doi: 10.1186/1478-811X-12-14.

3.

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours.

Rebouissou S, Amessou M, Couchy G, Poussin K, Imbeaud S, Pilati C, Izard T, Balabaud C, Bioulac-Sage P, Zucman-Rossi J.

Nature. 2009 Jan 8;457(7226):200-4. doi: 10.1038/nature07475. Epub 2008 Nov 19.

4.

gp130 activation is regulated by D2-D3 interdomain connectivity.

Schütt A, Zacharias M, Schneider N, Horn S, Grötzinger J, Rose-John S, Schmidt-Arras D.

Biochem J. 2013 Mar 15;450(3):487-96. doi: 10.1042/BJ20121660.

PMID:
23294003
5.

Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling.

Sommer J, Effenberger T, Volpi E, Waetzig GH, Bernhardt M, Suthaus J, Garbers C, Rose-John S, Floss DM, Scheller J.

J Biol Chem. 2012 Apr 20;287(17):13743-51. doi: 10.1074/jbc.M111.349167.

6.

Determinants of secretion and intracellular localization of human herpesvirus 8 interleukin-6.

Chen D, Choi YB, Sandford G, Nicholas J.

J Virol. 2009 Jul;83(13):6874-82. doi: 10.1128/JVI.02625-08. Epub 2009 Apr 22.

7.

Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth.

Suthaus J, Tillmann A, Lorenzen I, Bulanova E, Rose-John S, Scheller J.

Mol Biol Cell. 2010 Aug 1;21(15):2797-807. doi: 10.1091/mbc.E10-03-0240. Epub 2010 Jun 16. Erratum in: Mol Biol Cell. 2011 Jun;22(12):2132.

8.

Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma.

Poussin K, Pilati C, Couchy G, Calderaro J, Bioulac-Sage P, Bacq Y, Paradis V, Leteurtre E, Sturm N, Ramos J, Guettier C, Bardier-Dupas A, Boulai A, Wendum D, Selves J, Izard T, Nault JC, Zucman-Rossi J.

Oncoimmunology. 2013 Dec 1;2(12):e27090. Epub 2014 Jan 3.

9.

Key role of suppressor of cytokine signaling 3 in regulating gp130 cytokine-induced signaling and limiting chondrocyte responses during murine inflammatory arthritis.

Liu X, Croker BA, Campbell IK, Gauci SJ, Alexander WS, Tonkin BA, Walsh NC, Linossi EM, Nicholson SE, Lawlor KE, Wicks IP.

Arthritis Rheumatol. 2014 Sep;66(9):2391-402. doi: 10.1002/art.38701.

10.

Role of human herpesvirus 8 interleukin-6-activated gp130 signal transducer in primary effusion lymphoma cell growth and viability.

Cousins E, Nicholas J.

J Virol. 2013 Oct;87(19):10816-27. doi: 10.1128/JVI.02047-13. Epub 2013 Jul 31.

11.

IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling.

Traum D, Timothee P, Silver J, Rose-John S, Ernst M, LaRosa DF.

J Leukoc Biol. 2012 Mar;91(3):427-35. doi: 10.1189/jlb.0411209. Epub 2011 Dec 2.

12.

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas.

Pilati C, Amessou M, Bihl MP, Balabaud C, Nhieu JT, Paradis V, Nault JC, Izard T, Bioulac-Sage P, Couchy G, Poussin K, Zucman-Rossi J.

J Exp Med. 2011 Jul 4;208(7):1359-66. doi: 10.1084/jem.20110283. Epub 2011 Jun 20.

13.

c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130.

Tanaka Y, Tanaka N, Saeki Y, Tanaka K, Murakami M, Hirano T, Ishii N, Sugamura K.

Mol Cell Biol. 2008 Aug;28(15):4805-18. doi: 10.1128/MCB.01784-07. Epub 2008 Jun 2.

14.

N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.

Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Vallés Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D.

J Biol Chem. 2010 Jan 15;285(3):1781-9. doi: 10.1074/jbc.M109.075952. Epub 2009 Nov 13.

15.

Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation.

Yeoh GC, Ernst M, Rose-John S, Akhurst B, Payne C, Long S, Alexander W, Croker B, Grail D, Matthews VB.

Hepatology. 2007 Feb;45(2):486-94.

PMID:
17256754
16.

Capsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress.

Lee HK, Seo IA, Shin YK, Park JW, Suh DJ, Park HT.

Biochem Biophys Res Commun. 2009 May 1;382(2):445-50. doi: 10.1016/j.bbrc.2009.03.046. Epub 2009 Mar 13.

PMID:
19285962
17.

Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130.

Kurth I, Horsten U, Pflanz S, Timmermann A, Küster A, Dahmen H, Tacken I, Heinrich PC, Müller-Newen G.

J Immunol. 2000 Jan 1;164(1):273-82.

18.

SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130.

Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F.

J Biol Chem. 2003 Jan 3;278(1):661-71. Epub 2002 Oct 27.

19.
20.

A designer hyper interleukin 11 (H11) is a biologically active cytokine.

Dams-Kozlowska H, Gryska K, Kwiatkowska-Borowczyk E, Izycki D, Rose-John S, Mackiewicz A.

BMC Biotechnol. 2012 Mar 21;12:8. doi: 10.1186/1472-6750-12-8.

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