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Apoptosis and DNA methylation.

Meng HX, Hackett JA, Nestor C, Dunican DS, Madej M, Reddington JP, Pennings S, Harrison DJ, Meehan RR.

Cancers (Basel). 2011 Apr 1;3(2):1798-820. doi: 10.3390/cancers3021798.


MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles.

Sjolund AB, Senejani AG, Sweasy JB.

Mutat Res. 2013 Mar-Apr;743-744:12-25. doi: 10.1016/j.mrfmmm.2012.11.001. Epub 2012 Nov 26. Review.


Structural and mutation studies of two DNA demethylation related glycosylases: MBD4 and TDG.

Hashimoto H.

Biophysics (Nagoya-shi). 2014 Oct 18;10:63-8. doi: 10.2142/biophysics.10.63. eCollection 2014. Review.


Characterization of Dnmt3b:thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA.

Boland MJ, Christman JK.

J Mol Biol. 2008 Jun 6;379(3):492-504. doi: 10.1016/j.jmb.2008.02.049. Epub 2008 Feb 29.


Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites.

Bellacosa A, Drohat AC.

DNA Repair (Amst). 2015 Aug;32:33-42. doi: 10.1016/j.dnarep.2015.04.011. Epub 2015 May 1. Review.


Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.

Moréra S, Grin I, Vigouroux A, Couvé S, Henriot V, Saparbaev M, Ishchenko AA.

Nucleic Acids Res. 2012 Oct;40(19):9917-26. doi: 10.1093/nar/gks714. Epub 2012 Jul 30.


Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands.

Talhaoui I, Couve S, Gros L, Ishchenko AA, Matkarimov B, Saparbaev MK.

Nucleic Acids Res. 2014 Jun;42(10):6300-13. doi: 10.1093/nar/gku246. Epub 2014 Apr 1.


Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability.

Cortázar D, Kunz C, Selfridge J, Lettieri T, Saito Y, MacDougall E, Wirz A, Schuermann D, Jacobs AL, Siegrist F, Steinacher R, Jiricny J, Bird A, Schär P.

Nature. 2011 Feb 17;470(7334):419-23. doi: 10.1038/nature09672. Epub 2011 Jan 30.


Modulation of the activity of methyl binding domain protein 4 (MBD4/MED1) while processing iododeoxyuridine generated DNA mispairs.

Aziz MA, Schupp JE, Kinsella TJ.

Cancer Biol Ther. 2009 Jun;8(12):1156-63. Epub 2009 Jun 25.


[Structure basis of versatile base recognition of MBD4].

Ariyoshi M, Otani J, Shirakawa M.

Yakugaku Zasshi. 2015;135(1):3-9. doi: 10.1248/yakushi.14-00202-1. Review. Japanese.


5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence.

Zhu B, Zheng Y, Angliker H, Schwarz S, Thiry S, Siegmann M, Jost JP.

Nucleic Acids Res. 2000 Nov 1;28(21):4157-65.


Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair.

Yoon JH, Iwai S, O'Connor TR, Pfeifer GP.

Nucleic Acids Res. 2003 Sep 15;31(18):5399-404.


Crystal structure of human methyl-binding domain IV glycosylase bound to abasic DNA.

Manvilla BA, Maiti A, Begley MC, Toth EA, Drohat AC.

J Mol Biol. 2012 Jul 13;420(3):164-75. doi: 10.1016/j.jmb.2012.04.028. Epub 2012 May 2.


Base excision repair of tandem modifications in a methylated CpG dinucleotide.

Sassa A, Çağlayan M, Dyrkheeva NS, Beard WA, Wilson SH.

J Biol Chem. 2014 May 16;289(20):13996-4008. doi: 10.1074/jbc.M114.557769. Epub 2014 Apr 2.


Crystal structure of the mismatch-specific thymine glycosylase domain of human methyl-CpG-binding protein MBD4.

Zhang W, Liu Z, Crombet L, Amaya MF, Liu Y, Zhang X, Kuang W, Ma P, Niu L, Qi C.

Biochem Biophys Res Commun. 2011 Sep 2;412(3):425-8. doi: 10.1016/j.bbrc.2011.07.091. Epub 2011 Jul 28.


Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA.

Maiti A, Noon MS, MacKerell AD Jr, Pozharski E, Drohat AC.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8091-6. doi: 10.1073/pnas.1201010109. Epub 2012 May 9.


The Mechanisms of Generation, Recognition, and Erasure of DNA 5-Methylcytosine and Thymine Oxidations.

Hashimoto H, Zhang X, Vertino PM, Cheng X.

J Biol Chem. 2015 Aug 21;290(34):20723-33. doi: 10.1074/jbc.R115.656884. Epub 2015 Jul 7. Review.


MBD4-mediated glycosylase activity on a chromatin template is enhanced by acetylation.

Ishibashi T, So K, Cupples CG, Ausió J.

Mol Cell Biol. 2008 Aug;28(15):4734-44. doi: 10.1128/MCB.00588-08. Epub 2008 Jun 2.


The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites.

Hendrich B, Hardeland U, Ng HH, Jiricny J, Bird A.

Nature. 1999 Sep 16;401(6750):301-4. Erratum in: Nature 2000 Mar 30;404(6777):525.


Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair.

Li YQ, Zhou PZ, Zheng XD, Walsh CP, Xu GL.

Nucleic Acids Res. 2007;35(2):390-400. Epub 2006 Dec 14.

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