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Items: 1 to 20 of 78


Development of a fluorescence polarization based high-throughput assay to identify Casitas B-lineage lymphoma RING domain regulators.

Xie X, Sun L, Pessetto ZY, Zhao Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Sun Y.

PLoS One. 2013 Oct 31;8(10):e78042. doi: 10.1371/journal.pone.0078042. eCollection 2013.


High-throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-protein tyrosine kinase interactions.

Kumar EA, Charvet CD, Lokesh GL, Natarajan A.

Anal Biochem. 2011 Apr 15;411(2):254-60. doi: 10.1016/j.ab.2010.11.038. Epub 2010 Dec 1.


E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity.

Huang A, de Jong RN, Wienk H, Winkler GS, Timmers HT, Boelens R.

J Mol Biol. 2009 Jan 16;385(2):507-19. doi: 10.1016/j.jmb.2008.10.044. Epub 2008 Nov 1.


Casitas B-Lineage Lymphoma RING Domain Inhibitors Protect Mice against High-Fat Diet-Induced Obesity and Insulin Resistance.

Wu M, Sun L, Pessetto ZY, Zang Z, Xie X, Zhong L, Su Q, Zan W, Gao X, Zhao Y, Sun Y.

PLoS One. 2015 Aug 21;10(8):e0135916. doi: 10.1371/journal.pone.0135916. eCollection 2015.


Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5.

Ryan PE, Kales SC, Yadavalli R, Nau MM, Zhang H, Lipkowitz S.

PLoS One. 2012;7(11):e49428. doi: 10.1371/journal.pone.0049428. Epub 2012 Nov 7.


Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7.

Yokouchi M, Kondo T, Houghton A, Bartkiewicz M, Horne WC, Zhang H, Yoshimura A, Baron R.

J Biol Chem. 1999 Oct 29;274(44):31707-12.


The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.

Ryan PE, Sivadasan-Nair N, Nau MM, Nicholas S, Lipkowitz S.

J Biol Chem. 2010 Jul 30;285(31):23687-98. doi: 10.1074/jbc.M109.091157. Epub 2010 Jun 4.


Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B.

Qiao G, Lei M, Li Z, Sun Y, Minto A, Fu YX, Ying H, Quigg RJ, Zhang J.

J Immunol. 2007 Oct 1;179(7):4473-9.


Casitas B-lineage lymphoma mutants activate AKT to induce transformation in cooperation with class III receptor tyrosine kinases.

Polzer H, Janke H, Schmid D, Hiddemann W, Spiekermann K.

Exp Hematol. 2013 Mar;41(3):271-80.e4. doi: 10.1016/j.exphem.2012.10.016. Epub 2012 Nov 2.


Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.

Buetow L, Tria G, Ahmed SF, Hock A, Dou H, Sibbet GJ, Svergun DI, Huang DT.

BMC Biol. 2016 Sep 8;14:76. doi: 10.1186/s12915-016-0298-6.


The ubiquitin E3 ligase Cbl-b in T cells tolerance and tumor immunity.

Loeser S, Penninger JM.

Cell Cycle. 2007 Oct 15;6(20):2478-85. Epub 2007 Jul 26. Review.


CBL enhances breast tumor formation by inhibiting tumor suppressive activity of TGF-β signaling.

Kang JM, Park S, Kim SJ, Hong HY, Jeong J, Kim HS, Kim SJ.

Oncogene. 2012 Dec 13;31(50):5123-31. doi: 10.1038/onc.2012.18. Epub 2012 Feb 6.


Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.

Simmons A, Gangadharan B, Hodges A, Sharrocks K, Prabhakar S, García A, Dwek R, Zitzmann N, McMichael A.

Immunity. 2005 Dec;23(6):621-34.


High-throughput fluorescence polarization assay to identify small molecule inhibitors of BRCT domains of breast cancer gene 1.

Lokesh GL, Rachamallu A, Kumar GD, Natarajan A.

Anal Biochem. 2006 May 1;352(1):135-41. Epub 2006 Feb 3.


Targeting the E3 ubiquitin casitas B-lineage lymphoma decreases osteosarcoma cell growth and survival and reduces tumorigenesis.

Sévère N, Dieudonné FX, Marty C, Modrowski D, Patiño-García A, Lecanda F, Fromigué O, Marie PJ.

J Bone Miner Res. 2012 Oct;27(10):2108-17. doi: 10.1002/jbmr.1667.


c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G.

Rafiq K, Guo J, Vlasenko L, Guo X, Kolpakov MA, Sanjay A, Houser SR, Sabri A.

J Biol Chem. 2012 Feb 17;287(8):5327-39. doi: 10.1074/jbc.M111.307009. Epub 2011 Dec 27.


Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b.

Loeser S, Penninger JM.

Semin Immunol. 2007 Jun;19(3):206-14. Epub 2007 Mar 27. Review.


Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.

Zheng N, Wang P, Jeffrey PD, Pavletich NP.

Cell. 2000 Aug 18;102(4):533-9.


Effects of RING-SH2Grb², a chimeric protein containing the E3 ligase domain of Cbl, on the EGFR pathway.

Lee WH, Wang PY, Lin YH, Chou HY, Lee YH, Lee CK, Pai LM.

Chin J Physiol. 2014 Dec 31;57(6):350-7. doi: 10.4077/CJP.2014.BAD281.


Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.

Naramura M, Nandwani N, Gu H, Band V, Band H.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16274-9. doi: 10.1073/pnas.1007575107. Epub 2010 Aug 30.

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