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Items: 1 to 20 of 114

1.

SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1.

Zhou X, Fan LX, Li K, Ramchandran R, Calvet JP, Li X.

Hum Mol Genet. 2014 Mar 15;23(6):1644-55. doi: 10.1093/hmg/ddt556. Epub 2013 Nov 7.

2.

The retinitis pigmentosa protein RP2 interacts with polycystin 2 and regulates cilia-mediated vertebrate development.

Hurd T, Zhou W, Jenkins P, Liu CJ, Swaroop A, Khanna H, Martens J, Hildebrandt F, Margolis B.

Hum Mol Genet. 2010 Nov 15;19(22):4330-44. doi: 10.1093/hmg/ddq355. Epub 2010 Aug 20.

3.

The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes.

Fogelgren B, Lin SY, Zuo X, Jaffe KM, Park KM, Reichert RJ, Bell PD, Burdine RD, Lipschutz JH.

PLoS Genet. 2011 Apr;7(4):e1001361. doi: 10.1371/journal.pgen.1001361. Epub 2011 Apr 7.

4.

Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis.

Greer YE, Westlake CJ, Gao B, Bharti K, Shiba Y, Xavier CP, Pazour GJ, Yang Y, Rubin JS.

Mol Biol Cell. 2014 May;25(10):1629-40. doi: 10.1091/mbc.E13-10-0598. Epub 2014 Mar 19.

5.

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway.

Hartman TR, Liu D, Zilfou JT, Robb V, Morrison T, Watnick T, Henske EP.

Hum Mol Genet. 2009 Jan 1;18(1):151-63. doi: 10.1093/hmg/ddn325. Epub 2008 Oct 9.

6.

Loss of polycystin-1 causes centrosome amplification and genomic instability.

Battini L, Macip S, Fedorova E, Dikman S, Somlo S, Montagna C, Gusella GL.

Hum Mol Genet. 2008 Sep 15;17(18):2819-33. doi: 10.1093/hmg/ddn180. Epub 2008 Jun 19.

7.

Regulation of polycystin-1 ciliary trafficking by motifs at its C-terminus and polycystin-2 but not by cleavage at the GPS site.

Su X, Wu M, Yao G, El-Jouni W, Luo C, Tabari A, Zhou J.

J Cell Sci. 2015 Nov 15;128(22):4063-73. doi: 10.1242/jcs.160556. Epub 2015 Oct 1.

8.

Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling.

Xu C, Rossetti S, Jiang L, Harris PC, Brown-Glaberman U, Wandinger-Ness A, Bacallao R, Alper SL.

Am J Physiol Renal Physiol. 2007 Mar;292(3):F930-45. Epub 2006 Nov 7.

9.
10.

Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein.

Su X, Driscoll K, Yao G, Raed A, Wu M, Beales PL, Zhou J.

Hum Mol Genet. 2014 Oct 15;23(20):5441-51. doi: 10.1093/hmg/ddu267. Epub 2014 Jun 16.

11.

Polycystin-2 cation channel function is under the control of microtubular structures in primary cilia of renal epithelial cells.

Li Q, Montalbetti N, Wu Y, Ramos A, Raychowdhury MK, Chen XZ, Cantiello HF.

J Biol Chem. 2006 Dec 8;281(49):37566-75. Epub 2006 Sep 1.

12.

Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis.

Bisgrove BW, Snarr BS, Emrazian A, Yost HJ.

Dev Biol. 2005 Nov 15;287(2):274-88. Epub 2005 Oct 7.

13.

Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.

Sohara E, Luo Y, Zhang J, Manning DK, Beier DR, Zhou J.

J Am Soc Nephrol. 2008 Mar;19(3):469-76. doi: 10.1681/ASN.2006090985. Epub 2008 Jan 30.

14.

Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation.

AbouAlaiwi WA, Ratnam S, Booth RL, Shah JV, Nauli SM.

Hum Mol Genet. 2011 Jan 15;20(2):354-67. doi: 10.1093/hmg/ddq470. Epub 2010 Nov 1.

15.

Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein.

Zhao X, Jin M, Wang M, Sun L, Hong X, Cao Y, Wang C.

Cell Cycle. 2016 Sep;15(17):2367-75. doi: 10.1080/15384101.2016.1204059. Epub 2016 Jul 6.

16.

Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations.

Freedman BS, Lam AQ, Sundsbak JL, Iatrino R, Su X, Koon SJ, Wu M, Daheron L, Harris PC, Zhou J, Bonventre JV.

J Am Soc Nephrol. 2013 Oct;24(10):1571-86. doi: 10.1681/ASN.2012111089. Epub 2013 Sep 5.

17.

Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression.

Xiao Z, Zhang S, Mahlios J, Zhou G, Magenheimer BS, Guo D, Dallas SL, Maser R, Calvet JP, Bonewald L, Quarles LD.

J Biol Chem. 2006 Oct 13;281(41):30884-95. Epub 2006 Aug 11.

18.

Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures.

Natoli TA, Gareski TC, Dackowski WR, Smith L, Bukanov NO, Russo RJ, Husson H, Matthews D, Piepenhagen P, Ibraghimov-Beskrovnaya O.

Am J Physiol Renal Physiol. 2008 Jan;294(1):F73-83. Epub 2007 Oct 10.

19.

Role of the polycytin-primary cilia complex in bone development and mechanosensing.

Xiao ZS, Quarles LD.

Ann N Y Acad Sci. 2010 Mar;1192:410-21. doi: 10.1111/j.1749-6632.2009.05239.x. Review.

20.

Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease.

Low SH, Vasanth S, Larson CH, Mukherjee S, Sharma N, Kinter MT, Kane ME, Obara T, Weimbs T.

Dev Cell. 2006 Jan;10(1):57-69.

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