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DDB2 association with PCNA is required for its degradation after UV-induced DNA damage.

Cazzalini O, Perucca P, Mocchi R, Sommatis S, Prosperi E, Stivala LA.

Cell Cycle. 2014;13(2):240-8. doi: 10.4161/cc.26987. Epub 2013 Nov 4.


Spatiotemporal dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen.

Perucca P, Cazzalini O, Mortusewicz O, Necchi D, Savio M, Nardo T, Stivala LA, Leonhardt H, Cardoso MC, Prosperi E.

J Cell Sci. 2006 Apr 15;119(Pt 8):1517-27. Epub 2006 Mar 21.


Degradation of p21CDKN1A after DNA damage is independent of type of lesion, and is not required for DNA repair.

Savio M, Coppa T, Cazzalini O, Perucca P, Necchi D, Nardo T, Stivala LA, Prosperi E.

DNA Repair (Amst). 2009 Jul 4;8(7):778-85. doi: 10.1016/j.dnarep.2009.02.005. Epub 2009 Mar 24.


The xeroderma pigmentosum group E gene product DDB2 activates nucleotide excision repair by regulating the level of p21Waf1/Cip1.

Stoyanova T, Yoon T, Kopanja D, Mokyr MB, Raychaudhuri P.

Mol Cell Biol. 2008 Jan;28(1):177-87. Epub 2007 Oct 29.


CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation.

Nishitani H, Shiomi Y, Iida H, Michishita M, Takami T, Tsurimoto T.

J Biol Chem. 2008 Oct 24;283(43):29045-52. doi: 10.1074/jbc.M806045200. Epub 2008 Aug 14.


Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair.

Cazzalini O, Perucca P, Savio M, Necchi D, Bianchi L, Stivala LA, Ducommun B, Scovassi AI, Prosperi E.

Nucleic Acids Res. 2008 Mar;36(5):1713-22. doi: 10.1093/nar/gkn014. Epub 2008 Feb 7.


Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage.

Alekseev S, Luijsterburg MS, Pines A, Geverts B, Mari PO, Giglia-Mari G, Lans H, Houtsmuller AB, Mullenders LH, Hoeijmakers JH, Vermeulen W.

Mol Cell Biol. 2008 Dec;28(24):7402-13. doi: 10.1128/MCB.01108-08. Epub 2008 Oct 20.


PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

Soria G, Gottifredi V.

DNA Repair (Amst). 2010 Apr 4;9(4):358-64. doi: 10.1016/j.dnarep.2009.12.003. Epub 2010 Jan 8. Review.


DNA damage binding protein component DDB1 participates in nucleotide excision repair through DDB2 DNA-binding and cullin 4A ubiquitin ligase activity.

Li J, Wang QE, Zhu Q, El-Mahdy MA, Wani G, Praetorius-Ibba M, Wani AA.

Cancer Res. 2006 Sep 1;66(17):8590-7.


A DDB2 mutant protein unable to interact with PCNA promotes cell cycle progression of human transformed embryonic kidney cells.

Perucca P, Sommatis S, Mocchi R, Prosperi E, Stivala LA, Cazzalini O.

Cell Cycle. 2015;14(24):3920-8. doi: 10.1080/15384101.2015.1120921.


P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation.

Soria G, Podhajcer O, Prives C, Gottifredi V.

Oncogene. 2006 May 11;25(20):2829-38.


p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation.

Soria G, Speroni J, Podhajcer OL, Prives C, Gottifredi V.

J Cell Sci. 2008 Oct 1;121(Pt 19):3271-82. doi: 10.1242/jcs.027730. Epub 2008 Sep 9.


DDB2 decides cell fate following DNA damage.

Stoyanova T, Roy N, Kopanja D, Bagchi S, Raychaudhuri P.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10690-5. doi: 10.1073/pnas.0812254106. Epub 2009 Jun 16.


The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.

Guerrero-Santoro J, Kapetanaki MG, Hsieh CL, Gorbachinsky I, Levine AS, Rapić-Otrin V.

Cancer Res. 2008 Jul 1;68(13):5014-22. doi: 10.1158/0008-5472.CAN-07-6162.


Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC.

El-Mahdy MA, Zhu Q, Wang QE, Wani G, Praetorius-Ibba M, Wani AA.

J Biol Chem. 2006 May 12;281(19):13404-11. Epub 2006 Mar 8.


Resistance of human nucleotide excision repair synthesis in vitro to p21Cdn1.

Shivji MK, Ferrari E, Ball K, Hübscher U, Wood RD.

Oncogene. 1998 Dec 3;17(22):2827-38.


Assessing Cell Cycle Independent Function of the CDK Inhibitor p21(CDKN¹A) in DNA Repair.

Dutto I, Tillhon M, Prosperi E.

Methods Mol Biol. 2016;1336:123-39. doi: 10.1007/978-1-4939-2926-9_11.


The C-terminal domain of p21 inhibits nucleotide excision repair In vitro and In vivo.

Cooper MP, Balajee AS, Bohr VA.

Mol Biol Cell. 1999 Jul;10(7):2119-29.


Coordination between p21 and DDB2 in the cellular response to UV radiation.

Li H, Zhang XP, Liu F.

PLoS One. 2013 Nov 18;8(11):e80111. doi: 10.1371/journal.pone.0080111. eCollection 2013.

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