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Items: 1 to 20 of 125

1.

Altered intersubunit communication is the molecular basis for functional defects of pathogenic p97 mutants.

Tang WK, Xia D.

J Biol Chem. 2013 Dec 20;288(51):36624-35. doi: 10.1074/jbc.M113.488924. Epub 2013 Nov 6.

2.

A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants.

Tang WK, Li D, Li CC, Esser L, Dai R, Guo L, Xia D.

EMBO J. 2010 Jul 7;29(13):2217-29. doi: 10.1038/emboj.2010.104. Epub 2010 May 28.

3.

The role of the N-domain in the ATPase activity of the mammalian AAA ATPase p97/VCP.

Niwa H, Ewens CA, Tsang C, Yeung HO, Zhang X, Freemont PS.

J Biol Chem. 2012 Mar 9;287(11):8561-70. doi: 10.1074/jbc.M111.302778. Epub 2012 Jan 23.

4.

A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization.

Erzurumlu Y, Kose FA, Gozen O, Gozuacik D, Toth EA, Ballar P.

Int J Biochem Cell Biol. 2013 Apr;45(4):773-82. doi: 10.1016/j.biocel.2013.01.006. Epub 2013 Jan 16.

PMID:
23333620
5.
6.

Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation.

Halawani D, LeBlanc AC, Rouiller I, Michnick SW, Servant MJ, Latterich M.

Mol Cell Biol. 2009 Aug;29(16):4484-94. doi: 10.1128/MCB.00252-09. Epub 2009 Jun 8.

7.

Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation.

Weihl CC, Dalal S, Pestronk A, Hanson PI.

Hum Mol Genet. 2006 Jan 15;15(2):189-99. Epub 2005 Dec 1.

PMID:
16321991
8.

Structural and functional deviations in disease-associated p97 mutants.

Tang WK, Xia D.

J Struct Biol. 2012 Aug;179(2):83-92. doi: 10.1016/j.jsb.2012.04.024. Epub 2012 May 8. Review.

9.

Imbalances in p97 co-factor interactions in human proteinopathy.

Fernández-Sáiz V, Buchberger A.

EMBO Rep. 2010 Jun;11(6):479-85. doi: 10.1038/embor.2010.49. Epub 2010 Apr 23.

10.

Nucleocytoplasmic shuttling of valosin-containing protein (VCP/p97) regulated by its N domain and C-terminal region.

Song C, Wang Q, Song C, Lockett SJ, Colburn NH, Li CC, Wang JM, Rogers TJ.

Biochim Biophys Acta. 2015 Jan;1853(1):222-32. doi: 10.1016/j.bbamcr.2014.10.019. Epub 2014 Oct 30.

11.

Altered cofactor regulation with disease-associated p97/VCP mutations.

Zhang X, Gui L, Zhang X, Bulfer SL, Sanghez V, Wong DE, Lee Y, Lehmann L, Lee JS, Shih PY, Lin HJ, Iacovino M, Weihl CC, Arkin MR, Wang Y, Chou TF.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1705-14. doi: 10.1073/pnas.1418820112. Epub 2015 Mar 16.

12.

Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone.

Custer SK, Neumann M, Lu H, Wright AC, Taylor JP.

Hum Mol Genet. 2010 May 1;19(9):1741-55. doi: 10.1093/hmg/ddq050. Epub 2010 Feb 10.

PMID:
20147319
13.

Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy.

Ju JS, Weihl CC.

Hum Mol Genet. 2010 Apr 15;19(R1):R38-45. doi: 10.1093/hmg/ddq157. Epub 2010 Apr 21. Review.

14.

ATP-bound form of the D1 AAA domain inhibits an essential function of Cdc48p/p97.

Esaki M, Ogura T.

Biochem Cell Biol. 2010 Feb;88(1):109-17. doi: 10.1139/o09-116. Review.

PMID:
20130684
15.

Control of p97 function by cofactor binding.

Buchberger A, Schindelin H, Hänzelmann P.

FEBS Lett. 2015 Sep 14;589(19 Pt A):2578-89. doi: 10.1016/j.febslet.2015.08.028. Epub 2015 Aug 29. Review.

16.

IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation.

Bayraktar O, Oral O, Kocaturk NM, Akkoc Y, Eberhart K, Kosar A, Gozuacik D.

PLoS One. 2016 Oct 21;11(10):e0164864. doi: 10.1371/journal.pone.0164864. eCollection 2016. Erratum in: PLoS One. 2016 Nov 18;11(11):e0167192.

17.

Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model.

Chang YC, Hung WT, Chang YC, Chang HC, Wu CL, Chiang AS, Jackson GR, Sang TK.

PLoS Genet. 2011 Feb 3;7(2):e1001288. doi: 10.1371/journal.pgen.1001288.

18.

Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97.

Hänzelmann P, Schindelin H.

Structure. 2016 Jan 5;24(1):127-139. doi: 10.1016/j.str.2015.10.026. Epub 2015 Dec 17.

19.
20.

Rescue of growth defects of yeast cdc48 mutants by pathogenic IBMPFD-VCPs.

Takata T, Kimura Y, Ohnuma Y, Kawawaki J, Kakiyama Y, Tanaka K, Kakizuka A.

J Struct Biol. 2012 Aug;179(2):93-103. doi: 10.1016/j.jsb.2012.06.005. Epub 2012 Jun 19.

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