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Items: 1 to 20 of 89

1.

The abundant dietary constituent ferulic acid forms a wide range of metabolites including a glutathione adduct when incubated with rat hepatocytes.

Omar K, Grant MH, Henderson C, Watson DG.

Xenobiotica. 2014 May;44(5):432-7. doi: 10.3109/00498254.2013.853848. Epub 2013 Nov 6.

PMID:
24195590
2.

The complex degradation and metabolism of quercetin in rat hepatocyte incubations.

Omar K, Grant MH, Henderson C, Watson DG.

Xenobiotica. 2014 Dec;44(12):1074-82. doi: 10.3109/00498254.2014.932032. Epub 2014 Jun 24.

PMID:
24957985
3.

Metabolism of caffeic acid by isolated rat hepatocytes and subcellular fractions.

Moridani MY, Scobie H, O'Brien PJ.

Toxicol Lett. 2002 Jul 21;133(2-3):141-51.

PMID:
12119122
4.

Application of exogenous mixture of glutathione and stable isotope labeled glutathione for trapping reactive metabolites in cryopreserved human hepatocytes. Detection of the glutathione conjugates using high resolution accurate mass spectrometry.

Mezine I, Bode C, Raughley B, Bhoopathy S, Roberts KJ, Owen AJ, Hidalgo IJ.

Chem Biol Interact. 2013 Aug 25;204(3):173-84. doi: 10.1016/j.cbi.2013.05.011. Epub 2013 Jun 6.

PMID:
23747843
5.

Influence of ferulic acid on gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes.

Srinivasan M, Sudheer AR, Pillai KR, Kumar PR, Sudhakaran PR, Menon VP.

Toxicology. 2006 Dec 7;228(2-3):249-58. Epub 2006 Sep 19.

PMID:
17049709
6.

In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.

Yergey JA, Trimble LA, Silva J, Chauret N, Li C, Therien M, Grimm E, Nicoll-Griffith DA.

Drug Metab Dispos. 2001 May;29(5):638-44.

7.

Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes.

Grillo MP, Hua F.

Chem Res Toxicol. 2008 Sep;21(9):1749-59. doi: 10.1021/tx800098h. Epub 2008 Aug 5.

PMID:
18680316
8.

Metabolic products and pathways of fluorotelomer alcohols in isolated rat hepatocytes.

Martin JW, Mabury SA, O'Brien PJ.

Chem Biol Interact. 2005 Aug 15;155(3):165-80.

PMID:
16098497
9.
10.

Caffeic acid, chlorogenic acid, and dihydrocaffeic acid metabolism: glutathione conjugate formation.

Moridani MY, Scobie H, Jamshidzadeh A, Salehi P, O'Brien PJ.

Drug Metab Dispos. 2001 Nov;29(11):1432-9.

12.

Covalent binding of phenylacetic acid to protein in incubations with freshly isolated rat hepatocytes.

Grillo MP, Lohr MT.

Drug Metab Dispos. 2009 May;37(5):1073-82. doi: 10.1124/dmd.108.026153. Epub 2009 Feb 5.

13.
15.

Metabolism of para-aminophenol by rat hepatocytes.

Yan Z, Nikelly JG, Killmer L Jr, Tarloff JB.

Drug Metab Dispos. 2000 Aug;28(8):880-6.

16.

Identification of a novel glutathione conjugate of diclofenac by LTQ-Orbitrap.

Teffera Y, Waldon DJ, Colletti AE, Albrecht BK, Zhao Z.

Drug Metab Lett. 2008 Jan;2(1):35-40.

PMID:
19356068
17.

Comparison of genistein metabolism in rats and humans using liver microsomes and hepatocytes.

Bursztyka J, Perdu E, Tulliez J, Debrauwer L, Delous G, Canlet C, De Sousa G, Rahmani R, Benfenati E, Cravedi JP.

Food Chem Toxicol. 2008 Mar;46(3):939-48. Epub 2007 Oct 30.

PMID:
18063284
18.

Metabolomics provide new insight on the metabolism of dietary phytochemicals in rats.

Fardet A, Llorach R, Orsoni A, Martin JF, Pujos-Guillot E, Lapierre C, Scalbert A.

J Nutr. 2008 Jul;138(7):1282-7.

PMID:
18567748
19.

Metabolic activation of mefenamic acid leading to mefenamyl-S-acyl-glutathione adduct formation in vitro and in vivo in rat.

Grillo MP, Tadano Lohr M, Wait JC.

Drug Metab Dispos. 2012 Aug;40(8):1515-26. doi: 10.1124/dmd.112.046102. Epub 2012 May 10.

20.

Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates.

Carvalho M, Milhazes N, RemiĆ£o F, Borges F, Fernandes E, Amado F, Monks TJ, Carvalho F, Bastos ML.

Arch Toxicol. 2004 Jan;78(1):16-24. Epub 2003 Oct 28.

PMID:
14586543

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